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Keywords: fibrosis
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Biochem Soc Trans (2023) 51 (4): 1429–1436.
Published: 14 July 2023
... ( apovo@iib.uam.es ) or Lisardo Boscá ( lbosca@iib.uam.es ) 27 2 2023 29 6 2023 3 7 2023 cell homeostasis fibrosis immunometabolism inflammation macrophages monocytes The essence of the innate immune system has been tightly conserved through evolution. It includes...
Articles
Biochem Soc Trans (2022) 50 (4): 1129–1141.
Published: 05 August 2022
... Attribution License 4.0 (CC BY) . biomechanics FAK fibrosis pancreatic cancer priming Pancreatic cancer (PC) is predicted to be the second leading cause of cancer-related mortalities by 2026 [ 1 ]. Due to a lack of clinical features and perceptible symptoms at early-stage disease...
Articles
Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
... the levels and status of proteins in the ECM via multiple mechanisms. In so doing, Hsp90 regulates ECM dynamics, and changes in Hsp90 levels or activity support the development of ECM-related diseases, like cancer and fibrosis. Consequently, Hsp90 levels may have prognostic value, while inhibition of Hsp90...
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Articles
Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...
Articles
Biochem Soc Trans (2015) 43 (3): 513–518.
Published: 01 June 2015
... potential cardiac myocyte: fibroblast coupling connexin fibrosis gap junction ischaemia The trigger for cardiac contraction begins in the sinoatrial node (SAN), where electrical impulses are transmitted through the atria causing them to contract. Signals are delayed at the atrioventricular node...
Articles
Biochem Soc Trans (2009) 37 (4): 882–885.
Published: 22 July 2009
...Angara Sureshbabu; Hiroshi Okajima; Daisuke Yamanaka; Surya Shastri; Elizabeth Tonner; Colin Rae; Malgorzata Szymanowska; John H. Shand; Shin-Ichiro Takahashi; James Beattie; Gordon J. Allan; David J. Flint Fibrosis involves activation of fibroblasts, increased production of collagen...
Articles
Biochem Soc Trans (2008) 36 (5): 941–945.
Published: 19 September 2008
... together with glomerular hypertension leads to progressive glomerulosclerosis and tubulointerstitial fibrosis in susceptible individuals. Central to the pathology of DN are cytokines and growth factors such as TGF-β (transforming growth factor β) superfamily members, including BMPs (bone morphogenetic...
Articles
Biochem Soc Trans (2007) 35 (5): 1273–1277.
Published: 25 October 2007
... correspondence should be addressed (email akass@ucsd.edu ). 7 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 axonal regeneration chronic obstructive pulmonary disease (COPD) fibrosis neurotrophin peptide array phosphodiesterase 4A (PDE4A) cAMP...
Articles
Biochem Soc Trans (2007) 35 (4): 647–651.
Published: 20 July 2007
... fibrosis. These studies are leading to an appreciation of the complexity of events with multiple pathways involved, but, as the facts emerge, we are finding promising new ways to treat fibrosis and halt the inexorable progression that is a feature of so many fibrotic and remodelling disorders. cytokine...
Articles
Biochem Soc Trans (2007) 35 (4): 695–697.
Published: 20 July 2007
... expressed upon tissue damage, where it is up-regulated within 24 h of injury. Expression of tenascin-C is down-regulated and protein cleared from the tissue by the time repair is complete. Persistent expression of tenascin-C is associated with fibrotic diseases such as pulmonary fibrosis, scleroderma...
Articles
Biochem Soc Trans (2006) 34 (6): 1119–1123.
Published: 25 October 2006
... uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage – that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers...
Articles
Biochem Soc Trans (2002) 30 (2): 107–111.
Published: 01 April 2002
...C. D. Richards; C. Kerr; L. Tong; C. Langdon Metabolism of the extracellular matrix (ECM) is a complex process that becomes disregulated in disease states characterized by chronic inflammation of joints, as is seen in rheumatoid arthritis or fibrosis of the lung. The participation of certain...