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Keywords: fibrosis
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Articles
Biochem Soc Trans (2023) 51 (4): 1429–1436.
Published: 14 July 2023
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell homeostasis fibrosis immunometabolism inflammation macrophages monocytes The essence of the innate immune system...
Articles
Biochem Soc Trans (2022) 50 (4): 1129–1141.
Published: 05 August 2022
... and describe in this perspective how this could impact future cancer treatment. This highlights the significance of treatment timing and warrants further consideration of anti-fibrotic therapies in the clinical management of PDAC and other fibrotic diseases. biomechanics FAK fibrosis pancreatic cancer...
Articles
Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
... the levels and status of proteins in the ECM via multiple mechanisms. In so doing, Hsp90 regulates ECM dynamics, and changes in Hsp90 levels or activity support the development of ECM-related diseases, like cancer and fibrosis. Consequently, Hsp90 levels may have prognostic value, while inhibition of Hsp90...
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Articles
Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...
Articles
Biochem Soc Trans (2015) 43 (3): 513–518.
Published: 01 June 2015
... potential cardiac myocyte: fibroblast coupling connexin fibrosis gap junction ischaemia The trigger for cardiac contraction begins in the sinoatrial node (SAN), where electrical impulses are transmitted through the atria causing them to contract. Signals are delayed at the atrioventricular node...
Articles
Biochem Soc Trans (2009) 37 (4): 882–885.
Published: 22 July 2009
...Angara Sureshbabu; Hiroshi Okajima; Daisuke Yamanaka; Surya Shastri; Elizabeth Tonner; Colin Rae; Malgorzata Szymanowska; John H. Shand; Shin-Ichiro Takahashi; James Beattie; Gordon J. Allan; David J. Flint Fibrosis involves activation of fibroblasts, increased production of collagen...
Articles
Biochem Soc Trans (2008) 36 (5): 941–945.
Published: 19 September 2008
... together with glomerular hypertension leads to progressive glomerulosclerosis and tubulointerstitial fibrosis in susceptible individuals. Central to the pathology of DN are cytokines and growth factors such as TGF-β (transforming growth factor β) superfamily members, including BMPs (bone morphogenetic...
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Articles
Biochem Soc Trans (2007) 35 (4): 695–697.
Published: 20 July 2007
[email protected] ). 30 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 extracellular matrix fibroblast migration fibrosis provisional matrix tenascin-C tissue repair An effective response to tissue injury, for example following trauma, degenerative...
Articles
Biochem Soc Trans (2007) 35 (4): 647–651.
Published: 20 July 2007
... fibrosis. These studies are leading to an appreciation of the complexity of events with multiple pathways involved, but, as the facts emerge, we are finding promising new ways to treat fibrosis and halt the inexorable progression that is a feature of so many fibrotic and remodelling disorders. 1...
Articles
Biochem Soc Trans (2006) 34 (6): 1119–1123.
Published: 25 October 2006
... uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage – that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers...
Articles
Biochem Soc Trans (2002) 30 (2): 107–111.
Published: 01 April 2002
...C. D. Richards; C. Kerr; L. Tong; C. Langdon Metabolism of the extracellular matrix (ECM) is a complex process that becomes disregulated in disease states characterized by chronic inflammation of joints, as is seen in rheumatoid arthritis or fibrosis of the lung. The participation of certain...