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Keywords: folate
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Biochem Soc Trans (2006) 34 (2): 330–333.
Published: 20 March 2006
... to synthesis of polyamines or radical formation. SAM is regenerated from demethylated SAM via the methionine cycle, which involves folate. Imbalance of this cycle in humans, e.g. through folate shortage via dietary insufficiency, alcohol abuse, arsenic poisoning or hereditary factors, leads to depletion of SAM...
Biochem Soc Trans (2004) 32 (6): 1006–1007.
Published: 26 October 2004
... in [ 10 ]). Prader–Willi, Angelman's and Beckwith–Wiedemann syndromes all result from abnormal demethylation of the silenced allele of imprinted genes causing biallelic expression. Abnormalities in folate metabolism and DNA methylation have been associated with Down's syndrome, and aberrant DNA...