... cassette transporter (ABC transporter) folding membrane protein subunit interaction unfolding The correct folding and assembly of proteins is vital to cells, and unravelling the mechanisms behind these processes has become an intensive area of research. However, work in this field has...

... to their three-dimensional folds, and, in many cases, these folds are specified entirely by the sequence of the constituent amino acids or nucleic acids, and without the requirement for additional machinery to guide the formation of the structure. Thus sequence may often be sufficient to guide the assembly...

...D. Aili; K. Enander; L. Baltzer; B. Liedberg This contribution describes how de novo designed synthetic helix–loop–helix polypeptides are utilized to control the assembly of gold nanoparticles and as scaffolds for biosensing. The synthetic polypeptides are designed to fold into a four-helix bundle...

... this task efficiently, it shifts its p K a towards neutrality. Simulations and thermodynamic experiments implicate linkage between folding and protonation in nucleobase p K a shifting. Even small oligonucleotides are shown to fold in a highly co-operative manner, although they do so in a context-specific...

... that can directly introduce disulphide bonds into PDI [ 20 ]. Clearly, before any exact function during oxidative protein folding can be assigned to sulphydryl oxidase or other potential oxidases, we should be able to demonstrate not only the potential for these proteins to act as oxidases in vitro...

...J. D. Lear; H. Gratkowski; W. F. DeGrado Our current level of understanding of membrane-protein folding is primitive, but it is beginning to advance. Previously [Choma, Gratkowski, Lear and DeGrado (2000) Nat. Struct. Biol. 7, 161–166], we described studies of the association in detergent micelles...