... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . CRISPR functional genomics genetics genome editing genomics mouse models Cancer is a complex disease initiated and driven by a diverse spectrum of genetic and epigenetic alterations...

... of a broad range of biologically relevant questions. CRISPR functional genomics high-throughput screening induced pluripotent stem cells neurodegeneration Parkinson's disease The advent of clustered, regularly interspersed, short palindromic repeat (CRISPR) technologies has rapidly changed...

... the Creative Commons Attribution License 4.0 (CC BY) . developmental biology functional genomics gene expression and regulation gene regulatory networks Correspondence: Simon J. van Heeringen ( [email protected] ) A useful abstraction to study transcription regulation...

... functional genomics genetics There is growing evidence that cancer cells that become resistant to targeted therapies pay a price for their newfound abilities. The cellular pathways that govern proliferation are regulated at many distinct levels, which helps to guard against unrestrained signalling...

... Attribution License 4.0 (CC BY) . archaeal proteins computational biology functional genomics Figure 1. Dark matter in archaeal genomes. Amino acid sequences of proteins, encoded in 524 (nearly) completely sequenced archaeal genomes were, when possible, assigned to 13 443 arCOGs [ 16...

... fission yeast functional genomics Schizosaccharomyces pombe transcriptional-regulatory network transcription factor Transcriptional-regulatory networks determine the global gene expression profiles that give rise to specific cellular processes and phenotypes. Central to the network...

...David A. Fell; Mark G. Poolman; Albert Gevorgyan Reconstructing a model of the metabolic network of an organism from its annotated genome sequence would seem, at first sight, to be one of the most straightforward tasks in functional genomics, even if the various data sources required were never...

...Ravishankar Palanivelu; Mark A. Johnson The pollen tube represents an attractive model system for functional genomic analysis of the cell–cell interactions that mediate guided cellular growth. The pollen tube extends through pistil tissues and responds to guidance cues that direct the tube towards...

... functional genomics high-throughput protein expression immunohistological method protein localization reverse transfection The intracellular localization of gene products can provide important information about their function. Since the eukaryotic cell is characterized by a high degree...

... and abiotic characteristics in high-temperature habitats. Described here are functional genomics-based approaches, using cDNA microarrays, to gain insight into how ecological features such as biofilm formation, species interaction, and possibly even gene transfer may occur in native environments, as well...

... on native mRNAs, methods for ribozyme expression, and strategies for obtaining a discrete intracellular localization of ribozymes. 1 To whom correspondence should be addressed (e-mail [email protected] ) 27 8 2002 © 2002 Biochemical Society 2002 cancer functional genomics...