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Keywords: gating
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Biochem Soc Trans (2021) 49 (6): 2573–2579.
Published: 23 November 2021
...Andrea Saponaro; Gerhard Thiel; Anna Moroni Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are primarily activated by voltage and further modulated by cAMP. While cAMP binding alone does not open the channel, its presence facilitates the action of voltage, increasing channel...
Biochem Soc Trans (2015) 43 (2): 146–150.
Published: 07 April 2015
...Jemma L. Trick; Prafulla Aryal; Stephen J. Tucker; Mark S. P. Sansom Gating in channels and nanopores plays a key role in regulating flow of ions across membranes. Molecular simulations provide a ‘computational microscope’ which enables us to examine the physical nature of gating mechanisms...
Biochem Soc Trans (2006) 34 (5): 899–902.
Published: 25 October 2006
..., they differ more widely in the way their opening and closing, the gating, is governed. TASK and TALK subfamily proteins are two-pore region KCNK K + channels gated open by extracellular pH. We discuss the mechanism for this gating in terms of electrostatic effects on the pore changing the occupancy and open...
Biochem Soc Trans (2004) 32 (3): 529–534.
Published: 01 June 2004
...C.N. Connolly; K.A. Wafford The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT 3 (5-hydroxytryptamine; 5-HT 3 receptors), glycine and GABA (γ-aminobutyric acid; GABA A receptors). A vast knowledge...