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Keywords: gene expression
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 187–198.
Published: 23 December 2021
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . challenges gene expression multifunctionality SR proteins After completion of co-transcriptional splicing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 111–118.
Published: 12 January 2018
... , K. , Parr , T. and Tsintzas , K. ( 2010 ) Basal and insulin-stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise . Exp. Physiol. 95 , 808 – 818 10.1113/expphysiol...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... chemokine locus THP1 Tamm-Horsfall protein-1 monocytic cells UUO unilateral ureteral obstructive YY1 Ying Yang 1 biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important component of the founding of the field of biochemistry. Ever since the pioneering efforts...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1051–1057.
Published: 15 August 2016
... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer cell proliferation gene expression mRNA biogenesis polyadenylation post-transcriptional regulation of gene expression The closely coupled cleavage and polyadenylation reactions are key steps...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 279–285.
Published: 09 February 2016
... gene expression Inositides represent a large family of secondary messengers that are essential in the regulation of various cellular processes. This group of molecules may be classified either as water-soluble inositol polyphosphates (IPs) or inositol lipids [(phosphatidylinositols...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. TGFβ is a versatile growth factor that is involved in various cellular functions important in cancer...
Articles
Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza, Manlio Vinciguerra
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
... division, enabling cells to have different entities while containing the same genetic information. The heritability of the gene expression pattern is mediated by epigenetic modifications that include DNA methylation, PTMs of histone proteins and RNA-mediated gene silencing. Histone modifications...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1190–1195.
Published: 11 August 2014
... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...
Articles
Andrew Best, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Marina Danilenko, Ingrid Ehrmann, Alison Tyson-Capper, David J. Elliott
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Tra2 proteins are nuclear RNA-binding proteins involved in splicing regulation ( Figure 1 A). Tra2 proteins are conserved across the animal kingdom. Invertebrates have a single Tra2 protein copy (of which...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 495–499.
Published: 20 March 2014
... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
..., the CNV is particularly higher in genes which are environmentally sensitive that influence the responses to environmental stimulations [ 11 ]. Indeed, there is a significant association between CNVs with variability of either gene expression [ 12 ] or the important regulatory sequences that are located...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology Codon bias is defined...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 741–749.
Published: 23 May 2013
... (email smc57@le.ac.uk ). 30 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 deacetylase gene expression histone deacetylase 1 (HDAC1) histone deacetylase 2 (HDAC2) The ϵ-acetylation of lysine residues (Lys-Ac) is an abundant post-translational...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1735–1741.
Published: 21 November 2011
... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
... methylation to be a therapeutic target. 1 email v.h.cowling@dundee.ac.uk 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription The Myc family genes c...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1500–1505.
Published: 24 November 2010
... of NMD in cellular growth and development of an organism. 1 To whom correspondence should be addressed (email mip22@cam.ac.uk ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1125–1130.
Published: 26 July 2010
... ancestor with a diverse set of spliced leader RNA genes. 1 To whom correspondence should be addressed (email b.mueller@abdn.ac.uk ). 26 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 eukaryote gene expression metazoan RNA processing RNA splicing...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 708–711.
Published: 22 July 2008
...Laura Smith Post-transcriptional regulation, via 5′-UTRs (5′-untranslated regions), plays an important role in the control of eukaryotic gene expression. Recent analyses of the mammalian transcriptome suggest that most of the genes express multiple alternative 5′-UTRs and inappropriate expression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... by I-dsRNA occurs both by reducing mRNA levels and by inhibiting of translation. This finding has important functional consequences for hyperediting by ADARs. In addition to the effect of I-dsRNA on reporter gene expression, metabolic labelling experiments showed that endogenous gene expression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
... protamines can be detected in spermatid nuclei. 1 To whom correspondence should be addressed (email helen.white-cooper@zoo.ox.ac.uk ). 17 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Drosophila gene expression meiosis RNA localization...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1138–1140.
Published: 25 October 2006
... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 705–710.
Published: 25 October 2006
...-associated herpesvirus). All herpesviruses are nuclear replicating viruses that subvert cellular processes such as nucleocytoplasmic transport for their advantage. For virus replication to take over the cell and produce lytic infection requires that virus gene expression outpace that of the host cell. KSHV...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 30–34.
Published: 20 January 2006
...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 943–944.
Published: 26 October 2005
... to confirm our preliminary observations and to define the extent of this behaviour in Arabidopsis . Arabidopsis thaliana carbon allocation circadian control gene expression organ specificity phosphoenolpyruvate carboxylase kinase Many aspects of plant behaviour exhibit circadian...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
... hypothesis that loss of APC would lead to dysregulated proliferation [ 4 ]. adenomatous polyposis coli (APC) β-catenin colorectal cancer gene expression © 2005 The Biochemical Society 2005 30 3 2005 ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... adenoma–carcinoma sequence colorectal cancer DMBT1 (deleted in malignant brain tumour-1) gene expression tumour suppressor Changes in the glycosylation of a variety of glycoproteins, including mucins and tumour-suppressor-gene products, feature among the many studies designed to investigate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 733–735.
Published: 01 August 2005
... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (3): 499–501.
Published: 01 June 2005
...R.W.P. Smith; P. Malik; J.B. Clements The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1100–1102.
Published: 26 October 2004
... important to the processes maintaining colonic tissue homoeostasis. Mechanistically, the ability of butyrate to regulate gene expression is often attributed to its induction of histone hyperacetylation through inhibition of histone deacetylase [ 13 ]. However, it is clear that butyrate also induces...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
... the context of obesity [ 27 , 28 ]. This effect was ascribed to differential SREBP-1c (sterol-regulatory-element-binding protein 1c) gene expression, a key regulatory transcription factor involved in lipogenesis and glucose metabolism [ 29 – 31 ]. Feeding a c9,t11-CLA-rich diet had divergent tissue-specific...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1090–1092.
Published: 26 October 2004
... To whom correspondence should be addressed (email mwhite@liv.ac.uk ). 2 7 2004 © 2004 The Biochemical Society 2004 gene expression NF-κB oscillations transcription A stone thrown into water gives rise to oscillating ripples leading to a lasting perturbation of the smooth...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (4): 565–566.
Published: 01 August 2004
... gordon.simpson@scri.sari.ac.uk ). 20 3 2004 © 2004 The Biochemical Society 2004 alternative polyadenylation floral transition gene expression The floral transition is complex, involving the integration of responses to environmental cues with an endogenous programme of development...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 103–106.
Published: 01 February 2004
... Society 2004 cholesterol traffic fat cell gene expression lipid droplet sterol-response-element-binding protein (SREBP) triacylglycerol Abbreviations used: LDL, low-density lipoprotein; SREBP, sterol-response-element-binding protein; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1130–1132.
Published: 01 December 2003
... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 6 June 2003 © 2003 Biochemical Society 2003 fatty acid gene expression metabolism oxidation transgenic model Abbreviations used: DN, dominant-negative; H-FABP, heart fatty acid-binding protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 806–809.
Published: 01 August 2003
... Society 2003 bactericidal/permeability-increasing protein (BPI) gene expression gene structure host defence innate immunity lipopolysaccharide-binding protein (LBP) palate lung and nasal epithelium clone (PLUNC) Abbreviations used: BASE, breast cancer and salivary expressed; BPI...
