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Keywords: gene expression
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Articles
Biochem Soc Trans (2024) 52 (1): 455–464.
Published: 19 February 2024
...A. Contreras; C. Perea-Resa Transcription represents a central aspect of gene expression with RNA polymerase machineries (RNA Pol) driving the synthesis of RNA from DNA template molecules. In eukaryotes, a total of three RNA Pol enzymes generate the plethora of RNA species and RNA Pol II is the one...
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Biochem Soc Trans (2023) 51 (3): 1023–1034.
Published: 12 May 2023
.... Myosin I, mostly when interacting with chromatin remodellers, is established to facilitate chromosomal movement, chromatin rearrangements, transcription and gene expression regulation, and DNA damage repair [ 1 ]. Correspondence: Christopher P. Toseland ( [email protected] ) 14...
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Biochem Soc Trans (2022) 50 (1): 187–198.
Published: 23 December 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . challenges gene expression multifunctionality SR proteins Serine/arginine-rich splicing factors (SRSFs, SR proteins) are a phylogenetically conserved family of RNA-binding proteins (RBPs) present in all metazoans...
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Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
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Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... ailments. However, the potency in which lncRNAs can modulate gene expression in a plethora of cellular processes sets a precedent for lncRNAs to play a significant role in the etiology of human disease. biomarkers disease gene expression inflammation lncRNA transcriptional regulation...
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Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important component of the founding of the field of biochemistry. Ever since the pioneering efforts...
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Biochem Soc Trans (2016) 44 (4): 1051–1057.
Published: 15 August 2016
... The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer cell proliferation gene expression mRNA biogenesis polyadenylation post-transcriptional regulation of gene expression The closely coupled cleavage and polyadenylation reactions are key steps...
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Biochem Soc Trans (2016) 44 (1): 279–285.
Published: 09 February 2016
... gene expression Inositides represent a large family of secondary messengers that are essential in the regulation of various cellular processes. This group of molecules may be classified either as water-soluble inositol polyphosphates (IPs) or inositol lipids [(phosphatidylinositols...
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Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. 1 email [email protected] 13 10 2014 © The Authors Journal compilation ©...
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Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
... 10.1128/MCB.01233-08 19273605 47 Li Z. Thiel K. Thul P.J. Beller M. Kuhnlein R.P. Welte M.A. Lipid droplets control the maternal histone supply of Drosophila embryos Curr. Biol. 2012 22 2104 2113 10.1016/j.cub.2012.09.018 23084995 gene expression...
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Biochem Soc Trans (2014) 42 (4): 1190–1195.
Published: 11 August 2014
... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...
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Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Transcriptome-wide RNA targets for mouse Tra2β have been mapped by HITS-CLIP (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation) experiments [ 17 ]. The most frequent pentamers...
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Biochem Soc Trans (2014) 42 (2): 495–499.
Published: 20 March 2014
... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...
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Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
... association between CNVs with variability of either gene expression [ 12 ] or the important regulatory sequences that are located far apart from the actual target gene [ 13 ]. The mechanisms by which CNVs contribute to phenotype in human populations have been difficult to study, in part due...
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Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...
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Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. Pan2 also...
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Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email [email protected] 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology Codon bias is defined...
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Biochem Soc Trans (2013) 41 (3): 741–749.
Published: 23 May 2013
... (email [email protected] ). 30 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 deacetylase gene expression histone deacetylase 1 (HDAC1) histone deacetylase 2 (HDAC2) The ϵ-acetylation of lysine residues (Lys-Ac) is an abundant post-translational...
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Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...
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Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...
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Biochem Soc Trans (2011) 39 (6): 1735–1741.
Published: 21 November 2011
... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...
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Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...
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Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
... methylation to be a therapeutic target. 1 email [email protected] 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription Myc proteins are bHLH-LZ...
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Biochem Soc Trans (2010) 38 (6): 1500–1505.
Published: 24 November 2010
... of NMD in cellular growth and development of an organism. 1 To whom correspondence should be addressed (email [email protected] ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature...
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Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...
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Biochem Soc Trans (2010) 38 (4): 1125–1130.
Published: 26 July 2010
...′-untranslated regions that may contain detrimental sequences [ 20 , 21 ]. eukaryote gene expression metazoan RNA processing RNA splicing SL trans -splicing is the transfer of a short RNA sequence called SL RNA to the 5′ end of mRNAs by a mechanism involving components of the splicing machinery...
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Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
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Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
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Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...
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Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...
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Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...
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Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
... protamines can be detected in spermatid nuclei. Drosophila gene expression meiosis RNA localization spermatogenesis transcription In Drosophila , spermatogenesis is a stem-cell-mediated process. A germline stem cell divides asymmetrically to give another stem cell and a spermatogonial...
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Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...
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Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion. 1...
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Biochem Soc Trans (2006) 34 (6): 1138–1140.
Published: 25 October 2006
... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...
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Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...
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Biochem Soc Trans (2006) 34 (1): 30–34.
Published: 20 January 2006
...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...
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Biochem Soc Trans (2005) 33 (4): 733–735.
Published: 01 August 2005
... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...
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Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
... 1 email [email protected] 30 3 2005 © 2005 The Biochemical Society 2005 adenomatous polyposis coli (APC) β-catenin colorectal cancer gene expression The APC (adenomatous polyposis coli) gene encodes the APC tumour suppressor protein, germline mutation of which...
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Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... and show altered O-glycosylation through the progression to adenocarcinoma and mucinous carcinoma phenotypes [ 13 , 14 ]. We have used this model to examine the significance of MUC gene expression and the glycosylation patterns that are associated with progression to adenocarcinoma and mucinous carcinoma...
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Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
... interventions. 1 email [email protected] 25 8 2004 © 2004 The Biochemical Society 2004 fatty acid gene expression insulin resistance metabolic syndrome nutrigenomics sterol-regulatory-element-binding protein 1c (SREPB-1c) tumour necrosis factor-α (TNF-α) Nutritional...
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Biochem Soc Trans (2004) 32 (4): 565–566.
Published: 01 August 2004
... and γ transcripts) have not been detected. This may be because alternatively polyadenylated FLC transcripts are not stable or because FLC is not a direct target of FCA. Post-Transcriptional Regulation of Plant Gene Expression: Focused Meeting held at the University of East Anglia, Norwich...