1-50 of 55
Keywords: gene expression
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2018) 46 (1): 111–118.
Published: 12 January 2018
.... Correspondence: Francis Stephens ( f.b.stephens@exeter.ac.uk ) * These authors contributed equally to this work. 4 9 2017 23 11 2017 24 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exercise gene expression...
Articles
Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... of the Biochemical Society 2017 biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how the eukaryotic genomic code is arranged, regulated and transcribed. Simply defined as the transcribed yet...
Articles
Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... and engineered natural product pathways in living cells. Correspondence: Paul Freemont ( p.freemont@imperial.ac.uk ) 1 3 2017 24 3 2017 31 3 2017 cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important...
Articles
Biochem Soc Trans (2016) 44 (4): 1051–1057.
Published: 15 August 2016
... proliferation gene expression mRNA biogenesis polyadenylation post-transcriptional regulation of gene expression The closely coupled cleavage and polyadenylation reactions are key steps in the processing of most primary pre-mRNA transcripts into mature mRNA. Understanding of this process has...
Articles
Biochem Soc Trans (2016) 44 (1): 279–285.
Published: 09 February 2016
... ray.blind@vanderbilt.edu). 30 11 2015 © 2016 Authors; published by Portland Press Limited 2016 IPMK ipk2 ArgR inositide multikinase transcription gene expression Inositides represent a large family of secondary messengers that are essential in the regulation of various...
Articles
Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. The dysfunctional tumour vessels are poorly perfused and highly permeable, leading to areas...
Articles
Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
... Biochemical Society 2014 gene expression histone variant lipid metabolism nucleosome steatosis Canonical histones (H2A, H2B, H3 and H4) are assembled into nucleosomes during DNA replication to package it into chromatin. In contrast, histone variants are deposited independently of replication...
Articles
Biochem Soc Trans (2014) 42 (4): 1190–1195.
Published: 11 August 2014
... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...
Articles
Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... of gene expression Biochem. J. 2009 417 15 27 10.1042/BJ20081501 19061484 24 Aubol B.E. Jamros M.A. McGlone M.L. Adams J.A. Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate Biochemistry 2013 52 7595 7605 10.1021/bi4010864 24074032 25...
Articles
Biochem Soc Trans (2014) 42 (2): 495–499.
Published: 20 March 2014
... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...
Articles
Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
... of genome-wide CNV analysis. Analysing the CNV content to sub-10-kb resolution, over 1300 CNV regions (mostly <10 kb in length) were found spanning 3.2% (85 Mb) of the genome. Most CNVs mapped outside of the transcribed regions of genes. A total of 600 CNVs were associated with gene expression and only...
Articles
Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...
Articles
Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. 1...
Articles
Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... related to gene expression study, or more generally to understanding the biophysics and evolution of complex biological systems. Finally, I recommend further reading of previous relevant opinions generally related to the topic of this article [ 33 – 35 ]. Translation UK 2013: An Independent...
Articles
Biochem Soc Trans (2013) 41 (3): 741–749.
Published: 23 May 2013
... and small-molecule inhibitor studies is a reduction in cell proliferation. A generic role in cell cycle progression could be exploited in cancer cells, by blocking HDAC1/2 activity with small-molecule inhibitors, making them potentially useful drug targets. deacetylase gene expression histone...
Articles
Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...
Articles
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β transcriptome Alternative splicing introduces new coding information...
Articles
Biochem Soc Trans (2011) 39 (6): 1735–1741.
Published: 21 November 2011
... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...
Articles
Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
... v.h.cowling@dundee.ac.uk 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription The Myc family genes c- myc and N- myc are essential genes which regulate basic...
Articles
Biochem Soc Trans (2010) 38 (6): 1500–1505.
Published: 24 November 2010
... of NMD in cellular growth and development of an organism. 1 To whom correspondence should be addressed (email mip22@cam.ac.uk ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature...
Articles
Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...
Articles
Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...
Articles
Biochem Soc Trans (2010) 38 (4): 1125–1130.
Published: 26 July 2010
.... This has led to the identification of a set of unusual highly polymorphic SL RNAs [ 58 ]. During our initial investigation of gene expression in T. spiralis using the 5′ RACE (rapid amplification of cDNA ends) technique, we observed that several unrelated cDNAs had identical 21–24 nt sequences...
Articles
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
Articles
Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...
Articles
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
Articles
Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...
Articles
Biochem Soc Trans (2008) 36 (4): 708–711.
Published: 22 July 2008
...Laura Smith Post-transcriptional regulation, via 5′-UTRs (5′-untranslated regions), plays an important role in the control of eukaryotic gene expression. Recent analyses of the mammalian transcriptome suggest that most of the genes express multiple alternative 5′-UTRs and inappropriate expression...
Articles
Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA interference) pathway. dsRNA can...
Articles
Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
....). EGFP enhanced green fluorescent protein 1 To whom correspondence should be addressed (email helen.white-cooper@zoo.ox.ac.uk ). 17 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Drosophila gene expression meiosis RNA localization...
Articles
Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...
Articles
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion. 1...
Articles
Biochem Soc Trans (2006) 34 (5): 705–710.
Published: 25 October 2006
...-associated herpesvirus). All herpesviruses are nuclear replicating viruses that subvert cellular processes such as nucleocytoplasmic transport for their advantage. For virus replication to take over the cell and produce lytic infection requires that virus gene expression outpace that of the host cell. KSHV...
Articles
Biochem Soc Trans (2006) 34 (6): 1138–1140.
Published: 25 October 2006
... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...
Articles
Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...
Articles
Biochem Soc Trans (2006) 34 (1): 30–34.
Published: 20 January 2006
...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...
Articles
Biochem Soc Trans (2005) 33 (5): 943–944.
Published: 26 October 2005
... h.g.nimmo@bio.gla.ac.uk ). 26 7 2005 © 2005 The Biochemical Society 2005 Arabidopsis thaliana carbon allocation circadian control gene expression organ specificity phosphoenolpyruvate carboxylase kinase Many aspects of plant behaviour exhibit circadian rhythmicity...
Articles
Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
...-catenin colorectal cancer gene expression The APC (adenomatous polyposis coli) gene encodes the APC tumour suppressor protein, germline mutation of which characterizes FAP (familial adenomatous polyposis), an autosomal syndrome that is characterized by multiple colorectal lesions [ 1 ]. APC...
Articles
Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... and its glycosylation in the adenoma–carcinoma sequence leading to the adenocarcinoma phenotype. adenoma–carcinoma sequence colorectal cancer DMBT1 (deleted in malignant brain tumour-1) gene expression tumour suppressor Changes in the glycosylation of a variety of glycoproteins, including...
Articles
Biochem Soc Trans (2005) 33 (4): 733–735.
Published: 01 August 2005
... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...
Articles
Biochem Soc Trans (2005) 33 (3): 499–501.
Published: 01 June 2005
...R.W.P. Smith; P. Malik; J.B. Clements The herpes simplex virus 1 ICP27 is an essential, highly conserved protein involved in various steps of herpes simplex virus 1 gene regulation as well as in the shut-off of host gene expression during infection. It functions primarily at the post...
Articles
Biochem Soc Trans (2004) 32 (6): 1100–1102.
Published: 26 October 2004
... important to the processes maintaining colonic tissue homoeostasis. 1 To whom correspondence should be addressed (email spsb@liv.ac.uk ). 13 7 2004 © 2004 The Biochemical Society 2004 dietary fibre gene expression intestine monocarboxylate nutrient transport Adaptation...
Articles
Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
... interventions. 1 email hmroche@tcd.ie 25 8 2004 © 2004 The Biochemical Society 2004 fatty acid gene expression insulin resistance metabolic syndrome nutrigenomics sterol-regulatory-element-binding protein 1c (SREPB-1c) tumour necrosis factor-α (TNF-α) Nutritional...
Articles
Biochem Soc Trans (2004) 32 (6): 1090–1092.
Published: 26 October 2004
... To whom correspondence should be addressed (email mwhite@liv.ac.uk ). 2 7 2004 © 2004 The Biochemical Society 2004 gene expression NF-κB oscillations transcription A stone thrown into water gives rise to oscillating ripples leading to a lasting perturbation of the smooth...
Articles
Biochem Soc Trans (2004) 32 (4): 565–566.
Published: 01 August 2004
... gordon.simpson@scri.sari.ac.uk ). 20 3 2004 © 2004 The Biochemical Society 2004 alternative polyadenylation floral transition gene expression The floral transition is complex, involving the integration of responses to environmental cues with an endogenous programme of development...
Articles
Biochem Soc Trans (2004) 32 (1): 103–106.
Published: 01 February 2004
... Society 2004 cholesterol traffic fat cell gene expression lipid droplet sterol-response-element-binding protein (SREBP) triacylglycerol Abbreviations used: LDL, low-density lipoprotein; SREBP, sterol-response-element-binding protein; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA...
Articles
Biochem Soc Trans (2003) 31 (6): 1130–1132.
Published: 01 December 2003
... of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 6 June 2003 © 2003 Biochemical Society 2003 fatty acid gene expression metabolism oxidation transgenic model Abbreviations used: DN, dominant-negative; H-FABP, heart fatty acid-binding protein...
Articles
Biochem Soc Trans (2003) 31 (4): 806–809.
Published: 01 August 2003
... Society 2003 bactericidal/permeability-increasing protein (BPI) gene expression gene structure host defence innate immunity lipopolysaccharide-binding protein (LBP) palate lung and nasal epithelium clone (PLUNC) Abbreviations used: BASE, breast cancer and salivary expressed; BPI...
Articles
Biochem Soc Trans (2003) 31 (3): 728–730.
Published: 01 June 2003
... © 2003 Biochemical Society 2003 circadian rhythm crassulacean acid metabolism gene expression phosphoenolpyruvate carboxylase protein kinase Abbreviations used: CAM, crassulacean acid metabolism; PEPc, phosphoenolpyruvate carboxylase. 728 Biochemical Society Transactions...