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Keywords: gene expression
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Articles
Biochem Soc Trans (2024) 52 (1): 455–464.
Published: 19 February 2024
...A. Contreras; C. Perea-Resa Transcription represents a central aspect of gene expression with RNA polymerase machineries (RNA Pol) driving the synthesis of RNA from DNA template molecules. In eukaryotes, a total of three RNA Pol enzymes generate the plethora of RNA species and RNA Pol II is the one...
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Biochem Soc Trans (2023) 51 (3): 1023–1034.
Published: 12 May 2023
... by the participation of University of Sheffield in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. gene expression myosin nuclear myosin transcription Myosins are found throughout eukaryotic cells...
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Biochem Soc Trans (2022) 50 (1): 187–198.
Published: 23 December 2021
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . challenges gene expression multifunctionality SR proteins Serine/arginine-rich splicing factors (SRSFs, SR proteins) are a phylogenetically conserved family of RNA-binding proteins (RBPs) present in all metazoans...
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Biochem Soc Trans (2017) 45 (4): 987–997.
Published: 14 July 2017
...Tom Dendooven; Ben F. Luisi RNA acts not only as an information bearer in the biogenesis of proteins from genes, but also as a regulator that participates in the control of gene expression. In bacteria, small RNA molecules (sRNAs) play controlling roles in numerous processes and help to orchestrate...
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Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
...-coding genes were thought to be casual to many human ailments. However, the potency in which lncRNAs can modulate gene expression in a plethora of cellular processes sets a precedent for lncRNAs to play a significant role in the etiology of human disease. biomarkers disease gene expression...
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Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell free gene expression modelling prototyping synthetic biology Cell-free systems represent a historically important component of the founding of the field of biochemistry. Ever since the pioneering efforts...
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Biochem Soc Trans (2016) 44 (4): 1051–1057.
Published: 15 August 2016
...), as shown in T-cell activation [ 15 ], oncogenic transformation [ 16 , 17 ] and serum-induced fibroblast proliferation [ 18 ]. The potential for such global shifts to radically alter gene expression has attracted intense interest, but several studies have suggested that the effects on RNA stability...
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Biochem Soc Trans (2016) 44 (1): 279–285.
Published: 09 February 2016
... gene expression Inositides represent a large family of secondary messengers that are essential in the regulation of various cellular processes. This group of molecules may be classified either as water-soluble inositol polyphosphates (IPs) or inositol lipids [(phosphatidylinositols...
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Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. VEGF is the most prominent pro-angiogenic factor and is a crucial regulator of developmental blood...
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Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
... and maintain cell-type-specific gene expression patterns: nucleosome remodelling enzymes, histone PTMs, and, relevant to this review, the incorporation and exchange of canonical histones with histone variants. Known histone variants belong to the H1, H2 and H3 histone families [ 1 ], and give a further grade...
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Biochem Soc Trans (2014) 42 (4): 1190–1195.
Published: 11 August 2014
... accepted status as a major player in the regulation of eukaryotic gene expression. Although ~70% of human genes have been shown to contain multiple cleavage and polyadenylation sites, the extent of the consequences of APA and its role in regulating physiological processes are still largely unknown...
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Biochem Soc Trans (2014) 42 (4): 1152–1158.
Published: 11 August 2014
... alternative splicing Drosophila gene expression RNA recognition motif RS domain Tra2 Tra2 proteins are nuclear RNA-binding proteins involved in splicing regulation ( Figure 1 A). Tra2 proteins are conserved across the animal kingdom. Invertebrates have a single Tra2 protein copy (of which...
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Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
..., in part due to the difficulty in obtaining tissue samples and population heterogeneity. The estimation of the functional impact of CNV becomes possible by using an inbred mouse model which has known CNV for a certain gene by comparing CNV with the gene expression in vivo . This model is considered...
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Biochem Soc Trans (2014) 42 (2): 495–499.
Published: 20 March 2014
... I) and Glo2 (glyoxalase II) may be induced or suppressed, and rates of proteolysis of Glo1 and Glo2 proteins may change in health and disease. Quantitative assessment of glyoxalase gene expression at the mRNA and protein levels has become a key part of glyoxalase system characterization. For mRNA...
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Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
...Emma J. Mead; Rosalyn J. Masterton; Tobias von der Haar; Mick F. Tuite; C. Mark Smales Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career...
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Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2–Pan3 deadenylation complex. 1...
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Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology In summary, in the present article...
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Biochem Soc Trans (2013) 41 (3): 741–749.
Published: 23 May 2013
... (email smc57@le.ac.uk ). 30 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 deacetylase gene expression histone deacetylase 1 (HDAC1) histone deacetylase 2 (HDAC2) The ϵ-acetylation of lysine residues (Lys-Ac) is an abundant post-translational...
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Biochem Soc Trans (2012) 40 (4): 773–777.
Published: 20 July 2012
... are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle...
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Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... be addressed (email David.Elliott@ncl.ac.uk ). 17 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 development gene expression high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) RNA-binding proteins RNA splicing Tra2β...
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Biochem Soc Trans (2011) 39 (6): 1735–1741.
Published: 21 November 2011
... membrane are involved in tethering chromatin to the nuclear envelope and affect gene expression. They contain a common structural, bihelical motif, the so-called LEM domain, which mediates binding to a conserved chromatin protein, BAF (barrier to autointegration factor). Interestingly, this domain...
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Biochem Soc Trans (2010) 38 (6): 1598–1601.
Published: 24 November 2010
... methylation to be a therapeutic target. 1 email v.h.cowling@dundee.ac.uk 31 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell proliferation gene expression 7-methylguanosine cap mRNA translation c-Myc transcription The Myc family genes c...
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Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... rapidly, as regulation of these multiple steps in gene expression is implicated in diverse aspects of biology such as metabolism, neurology, reproduction and viral lifecycle regulation. Researchers who utilize various combinations of human studies, animal models, cellular, genetic, biochemical...
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Biochem Soc Trans (2010) 38 (6): 1500–1505.
Published: 24 November 2010
... of NMD in cellular growth and development of an organism. 1 To whom correspondence should be addressed (email mip22@cam.ac.uk ). 7 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression nonsense-mediated mRNA decay (NMD) premature...
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Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...Katrin Wiederhold; Lori A. Passmore The poly(A) tail of mRNA has an important influence on the dynamics of gene expression. On one hand, it promotes enhanced mRNA stability to allow production of the protein, even after inactivation of transcription. On the other hand, shortening of the poly...
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Biochem Soc Trans (2010) 38 (4): 1125–1130.
Published: 26 July 2010
... ancestor with a diverse set of spliced leader RNA genes. 1 To whom correspondence should be addressed (email b.mueller@abdn.ac.uk ). 26 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 eukaryote gene expression metazoan RNA processing RNA splicing...
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Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
...Ian C. Wood; Nicola K. Gray; Lesley Jones The brain is the most complex organ of the body and it contains the greatest diversity of cell types. Collectively, the cells within the brain express the greatest number of genes encoded within our genome. Inappropriate gene expression within these cells...
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Biochem Soc Trans (2009) 37 (6): 1276–1277.
Published: 19 November 2009
...John Hardy; Danyah Trabzuni; Mina Ryten Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases...
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Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
...Anna M. Randi; Andrea Sperone; Nicola H. Dryden; Graeme M. Birdsey Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally...
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Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
...Ian G. Cannell; Yi Wen Kong; Martin Bushell miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational...
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Biochem Soc Trans (2008) 36 (3): 497–501.
Published: 21 May 2008
...Oliver Mühlemann Among the different cellular surveillance mechanisms that ensure accurate gene expression, nonsense-mediated mRNA decay rapidly degrades mRNAs harbouring PTCs (premature translation-termination codons) and thereby prevents the accumulation of potentially deleterious proteins with C...
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Biochem Soc Trans (2008) 36 (3): 534–536.
Published: 21 May 2008
... adenosine deaminase that acts on RNA (ADAR) double-stranded RNA (dsRNA) editing gene expression stress granule translation The role of dsRNA (double-stranded RNA) in cells has been the subject of much recent research following the finding that it is an essential component of the RNAi (RNA...
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Biochem Soc Trans (2008) 36 (3): 540–542.
Published: 21 May 2008
... Monesi V. Synthetic activities during spermatogenesis in the mouse Exp. Cell Res. 1965 39 197 224 5 Schultz N. Hamra F. Garbers D. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets Proc. Natl. Acad...
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Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... chronic exposure, specific amino acids may influence gene expression in the β-cell, which have an impact on insulin secretion and cellular integrity. Therefore amino acids may play a direct or indirect (via generation of putative messengers of mitochondrial origin) role in insulin secretion. 1...
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Biochem Soc Trans (2006) 34 (6): 1138–1140.
Published: 25 October 2006
... hypertrophy can result in heart failure. One characteristic of hypertrophy is the re-expression of genes that are normally only expressed during foetal heart development. Although the involvement of these changes in gene expression in hypertrophy has been known for some years, the mechanisms involved...
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Biochem Soc Trans (2006) 34 (6): 1141–1144.
Published: 25 October 2006
... cholesterol homoeostasis gene expression lipoprotein lipase (LPL) transforming growth factor-β (TGF-β) The TGF-β superfamily comprises over 30 members that include TGF-β and a number of related factors (e.g. activins, nodals, bone morphogenetic proteins/growth and differentiation factors) [ 1...
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Biochem Soc Trans (2006) 34 (1): 30–34.
Published: 20 January 2006
...S.F. Newbury mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes...
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Biochem Soc Trans (2005) 33 (5): 943–944.
Published: 26 October 2005
... rhythmically and have identified ‘clusters’ of metabolically related genes that are expressed at particular times of the day [ 2 ]. For example, several genes expressed in late subjective afternoon encode proteins that function in the storage, transport or utilization of sugars. The promoters of many genes...
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Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... used this model to examine the significance of MUC gene expression and the glycosylation patterns that are associated with progression to adenocarcinoma and mucinous carcinoma phenotypes [ 13 , 14 ]. Independent support for a role of MUC genes in the development of intestinal cancers has recently...
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Biochem Soc Trans (2005) 33 (4): 733–735.
Published: 01 August 2005
... that a reduction in MCT1 expression, and hence butyrate transport, can lead to a reduction in the intracellular butyrate levels required to regulate gene expression. Collectively, our results highlight the important contribution of butyrate transport to the maintenance of tissue homoeostasis and disease prevention...
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Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
... determines gene expression and the metabolic response, which ultimately affects an individual's health status and/or predisposition to disease. Firstly, an individual's genetic background can determine nutrient status, metabolic response and predisposition to diet-related diseases [ 1 ]. Secondly, nutrients...
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Biochem Soc Trans (2004) 32 (4): 565–566.
Published: 01 August 2004
... alternative polyadenylation floral transition gene expression The floral transition is complex, involving the integration of responses to environmental cues with an endogenous programme of development. These responses are mediated by genetically separable pathways, which ensure that flowering occurs...