... be organized in time. In this case, transcription bodies mature from transcription factor clusters to elongating transcription bodies. This type of organization has important implications for transcription body function. (ii) The relevance of clustering for in vivo gene regulation has benefited greatly from...

... Society under a transformative agreement with JISC. epigenetics gene regulation preimplantation development transposable elements During preimplantation development, the zygote undergoes meticulously regulated cell divisions accompanied by global epigenetic reprogramming and activation...

.... , Wilson , B.G. , Wang , X. , Agoston , A.T. et al. ( 2017 ) ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice . Nat. Genet. 49 , 296 – 302 10.1038/ng.3744 20 Alver , B.H. , Kim , K.H. , Lu , P. , Wang , X. , Manchester , H.E...

... understanding of mechanisms underlying RP and RiBi gene regulation, with passing reference to their coordination with rRNA production. Work over many years has revealed a common set of TFs bound to most RPG upstream regulatory regions (hereafter referred to as promoters; [ 5–16 ]). The first...

... DRS. Improvements in tools that can increase the accuracy in base calling and detection of different base modifications in RNA are needed for wider adoption of this technology. Figure 1. Schematic illustration of widely used NGS platforms used to study co-/post-transcriptional gene regulation...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cancer gene regulation non-coding RNA nucleolus ribosomopathies Ribosome biogenesis is the essential, complex, and tightly regulated process in which large and small ribosomal subunits are assembled...

...Chun Kit Kwok RNA is one of the most fascinating biomolecules in living systems given its structural versatility to fold into elaborate architectures for important biological functions such as gene regulation, catalysis, and information storage. Knowledge of RNA structures and interactions can...

... activation. 1 To whom correspondence should be addressed (email [email protected] ) . 12 5 2015 © 2015 Authors; published by Portland Press Limited 2015 adaptive immunity cholesterol gene regulation innate immunity lipid rafts liver X receptors (LXRs) LXR...

... , endo-siRNAs are known as 22G and 26G RNAs and are involved in genome protection and gene regulation. Drosophila melanogaster endo-siRNAs are produced with the help of specific Dicer and Argonaute isoforms and play an essential role in transposon control and the protection from viral infections...

.... 1 To whom correspondence should be addressed (email [email protected] ). 4 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 Buruli ulcer gene regulation inflammation Mycobacterium ulcerans mycolactone One of the most striking...

... associated with them, and also explore some of the emerging evidence for their involvement in common human disease. 1 email [email protected] 24 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 antisense regulation epigenetic regulation gene...

..., but not to the nor or nnrR promoters [ 23 ]. Further investigations are needed in B. japonicum to demonstrate the involvement of RegR on norCBQD gene expression and to establish whether these genes are direct, or indirect, targets of RegR. Bradyrhizobium japonicum FixK 2 gene regulation NifA...

...Poonam Malik; Nikolaj Zuleger; Eric C. Schirmer The nuclear periphery is a specialized environment in the nucleus that contributes to genome organization and correspondingly to gene regulation. Mammalian chromosomes and certain genes occupy defined positions within the nucleus that are heritable...

... on the expression levels of key genes or pathways implicated in cancer. miRNAs play an important role in gene regulation whereby they can target genes containing sequences of complementarity to the mature miRNA sequence and thereby regulate the level of expression of the targeted genes by a variety...

... prokaryotic and eukaryotic transcription have yielded an increasing appreciation of the extent to which gene regulation is accomplished during the elongation phase of transcription. Transcriptional pausing is a fundamental enzymatic mechanism that underlies many of these regulatory schemes. In some cases...

... 2006 Bradyrhizobium japonicum cAMP receptor protein/fumarate and nitrate reductase regulatory protein-like transcription factor (CRP/FNR-like transcription factor) denitrification gene regulation nitrogen fixation symbiosis The superfamily of CRP (cAMP receptor protein)-like and FNR...

... of the experiments described. Escherichia coli gene regulation microarray nitric oxide Nrf regulatory system © 2006 The Biochemical Society 2006 8 9 2005 1 email [email protected] FNR is a transcriptional regulator, which contains an oxygen-sensitive [Fe-S...

... © 2005 The Biochemical Society 2005 anaerobiosis gene regulation molybdate transport nap genes nitrate respiration Species of the order Rhizobiales are best characterized for their ability to establish N 2 -fixing symbioses with leguminous plants. Bradyrhizobium japonicum...

... but the results are strongly suggestive that agents capable of normalizing junctional communication would have cancer-preventive properties. carotenoids connexin43 gap junctions gene regulation neoplastic transformation retinoids ...

...–DNA affinity. 1 To whom correspondence should be addressed (e-mail [email protected] ). Thermophiles 2003, a held at University of Exeter, 15–19 September 2003 19 September 2003 © 2004 Biochemical Society 2004 circular dichroism (CD) gene regulation histone fold histone...

..., which has a well-recognized function in gene regulation, provides a unique opportunity to investigate the functional significance of poly(amino acid) repeats in normal and disease states. 1 e-mail: [email protected] 21 12 2000 © 2001 Biochemical Society 2001 aggregation...

... © 2000 Biochemical Society 2000 expressed sequence tag gene regulation metabolism oxylipin EH, epoxide hydrolase Lipids and Signalling: Oxylipins 2 Hamberg, M. and Hamberg, G. ( 1990) Arch. Biochern. Biophys. 283,4094 I 6 Grechkin, A. N., Ilyasov, A. V. and Hamberg, M. ( I 997) Eur...

...I. Whitehouse; A. Flaus; K. Havas; T. Owen-Hughes Gene regulation involves the generation of a local chromatin topology that is conducive to transcription. Several classes of chromatin remodelling activity have been shown to play a role in this process. ATP-dependent chromatin-remodelling...