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Keyword: gene therapy
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Biochem Soc Trans (2018) 46 (5): 1247-1261.
Published: 09 October 2018
... The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bypass therapy gene therapy mitochondrial biogenesis mitochondrial dysfunction rapamycin...
Biochem Soc Trans (2018) 46 (1): 11-21.
Published: 01 December 2017
... behalf of the Biochemical Society 2018 cardiovascular disease gene therapy high-throughput screening microRNA The foundation of molecular biology states that DNA is copied to RNA by the process of transcription. The transcribed RNA then translates the information to produce proteins...
Biochem Soc Trans (2016) 44 (5): 1483-1490.
Published: 19 October 2016
... Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics The main function of mitochondria is to convert the energy derived from nutrients into heat and ATP, a high-energy molecule exploited by the cell biochemical machineries. This...
Biochem Soc Trans (2016) 44 (5): 1355-1365.
Published: 19 October 2016
... adverse effects. Therefore, more durable therapeutic strategies should be considered, such as a stable gene therapy to protect the target T cells against HIV-1 infection. The development of potent therapeutic regimens based on the RNA interference (RNAi) and clustered regularly interspaced short...
Biochem Soc Trans (2011) 39 (2): 584-588.
Published: 22 March 2011
..., College of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K. 2 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA looping gene therapy protein–protein interaction recognition sequence restriction enzyme Type II restriction endonucleases...
Biochem Soc Trans (2010) 38 (6): 1489-1493.
Published: 24 November 2010
... ). 15 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene therapy in utero gene transfer lysosomal storage disorder mouse nervous system viral vector Early lethal genetic diseases of the nervous system are individually rare, yet collectively numerous...
Biochem Soc Trans (2010) 38 (6): 1484-1488.
Published: 24 November 2010
... (insulin-like growth factor) II receptor provides an avenue for endocytosis, trafficking and lysosomal processing of extracellularly delivered enzyme. The present review discusses therapeutic utilization of cross-correction by enzyme-replacement therapy, gene therapy and stem cell therapy for the NCLs...
Biochem Soc Trans (2009) 37 (6): 1198-1200.
Published: 19 November 2009
... angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF) Therapeutic angiogenesis involves stimulation of angiogenesis, arteriogenesis and lymphangiogenesis [ 1 ]. Angiogenesis means sprouting, bridging, intussusception or enlargement of...
Biochem Soc Trans (2003) 31 (2): 397-406.
Published: 01 April 2003
... molecular probes as tools to throw light on the problematic steps in non-viral gene delivery which still impede efficient gene therapy. Thus, the current aims of our research are to understand, design and prepare small-molecule lipopolyamines for non-viral gene therapy (NVGT). The rational design and...