... and the Biochemical Society under a transformative agreement with JISC. cancer epigenetics genetic disease methylation In mammals, DNA methylation predominantly occurs on the cytosines of CpG dinucleotides [ 1 ] and is thought to facilitate the repression of some gene promoters and retrotransposons...

... on behalf of the Biochemical Society 2018 cancer DNA replication and recombination DNA synthesis and repair genetic disease genome integrity helicase Although RECQL4 lacks a WH domain, the C-terminal region of the protein is critical for helicase activity [ 2 ]. Nonetheless, the apparent...

..., both computationally and experimentally. Structure can also inform our understanding of impacts of mutations in human genetic diseases and drug resistance in cancers and infectious diseases. We discuss the ways that structural insights might be useful in both repurposing off-licence drugs and guide...

... The Authors Journal compilation © 2009 Biochemical Society 2009 anaemia ankyrin evolution genetic disease protein 4.1 spectrin Animal cells face demands that are different from (or at least additional to) those faced by simpler unicellular eukaryotes. For example, the forces engendered...

...-saarland.de ). 21 8 2006 © 2007 The Biochemical Society 2007 genetic disease knockout animal spontaneous mutation transgenic animal transient receptor potential gene (TRP gene) transient receptor potential melastatin 8 (TRPM8) The identification of the biological functions...

... The Biochemical Society 2006 1 To whom correspondence should be addressed (email V.M.O'[email protected] ). genetic disease model organism molecular determinant protein misfolding synapse synaptic function The Biochemical Society focused meeting ‘Molecular Determinants of Synaptic...

... genetic disease HIV nucleolus DMPK, dystrophica myotonica-protein kinase MDM2, murine double minute 2 Ribozymes and RNA Catalysis: Focused Meeting Organized by D. M. J. Lilley (Department of Biochemistry, University of Dundee) and F. Eckstein (Max-Planck Institute for Experimental...

... 2001 © 2001 Biochemical Society 2001 apoptosis toxicity xenobiotic genetic disease signal transduction SPT, serine palmitoyltransferase Enzymes that Regulate Lipid Metabolism in Cell Signalling Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its...

... of genetic diseases in which there is an impairment in one or more peroxisomal functions. One of the major functions of peroxisomes concerns their role in lipid metabolism, which includes: (i) fatty acid β-oxidation; (ii) ether phospholipid synthesis; (iii) fatty acid α-oxidation; and (iv) isoprenoid...