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Keywords: genome
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Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... Authors; published by Portland Press Limited 2015 cancer genome Kelch-like ECH-associated protein 1 (Keap1) nuclear factor E2-related factor 2 (Nrf2) oxidative stress The Cancer Genome Atlas (TCGA) Oxidative stress, an imbalance between the production and disposal of reactive oxygen...
Biochem Soc Trans (2015) 43 (1): 1–5.
Published: 26 January 2015
...Shankar Balasubramanian The primary sequence of DNA can be decoded a million times faster and cheaper than it could 20 years ago. This capability is transforming our understanding of biology and has stimulated efforts to influence modern medicine through routine sequencing of human genomes. I...
Biochem Soc Trans (2013) 41 (1): 427–431.
Published: 29 January 2013
..., and discuss important questions that should be addressed in the near future. 1 To whom correspondence should be addressed (email atomi@sbchem.kyoto-u.ac.jp ). 31 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Archaea CoA genome pantoate kinase...
Biochem Soc Trans (2011) 39 (2): 606–610.
Published: 22 March 2011
... pose a challenge for genome duplication. Damage to the template inhibits the replication machinery but proteins bound to the template such as RNA polymerases also present barriers to replication. This review discusses recent results from Escherichia coli that shed light on the roles of helicases...
Biochem Soc Trans (2005) 33 (4): 582–585.
Published: 01 August 2005
... , entered the European H. sapiens genome during the period of co-existence, and has spread through selection pressure to its current allele frequency of approx. 25% in this population [ 8 ]. The H2 allele is protective against two rare diseases: progressive supranuclear palsy and corticobasal degeneration...
Biochem Soc Trans (2005) 33 (2): 331–334.
Published: 01 April 2005
... or cancer. The completion of the human genome sequence allowed us to determine that more than 2% of all human genes are proteases or protease inhibitors, reflecting the importance of proteolysis in human biology. To understand better the complexity of proteases in human and other model organisms, we have...
Biochem Soc Trans (2004) 32 (4): 561–564.
Published: 01 August 2004
... to the alternative splicing process. Due to several duplication events, at least 19 SR proteins are present in the Arabidopsis genome, which is almost twice as many as in humans. They fall into seven different subfamilies, three of them homologous with metazoan splicing factors, whereas the other four seem...
Biochem Soc Trans (2004) 32 (2): 204–208.
Published: 01 April 2004
...: Fuselloviridae , Lipothrixviridae and Rudiviridae . They all have double-stranded DNA genomes and infect hyperthermophilic crenarchaea of the orders Sulfolobales and Thermoproteales. Representatives of the different viral families share a few homologous ORFs (open reading frames). However, about 90% of all ORFs...
Biochem Soc Trans (2004) 32 (2): 179–183.
Published: 01 April 2004
...K. Brügger; E. Torarinsson; P. Redder; L. Chen; R.A. Garrett Each of the sequenced Sulfolobus genomes contains large numbers of putatively mobile elements, both IS elements (insertion sequence elements) and MITEs (miniature inverted-repeat transposable elements). There are 344 in the 3.0 Mb genome...
Biochem Soc Trans (2001) 29 (2): 139–147.
Published: 01 May 2001
... systems. Apart from P450, these systems include a FAD flavoprotein or domain, a FMN domain, ferredoxins and cytochrome b 5 . Analysis of available complete genomes can shed light on what an ancestral P450-containing system could be. 1 To whom correspondence should be addressed (e-mail kirill...
Biochem Soc Trans (2000) 28 (6): 619–622.
Published: 01 December 2000
... mesocarp tissues, but no transcript was detected in any kernel tissues. Southern-blot analysis indicated the presence of a single gene and we have also isolated a genomic clone using the cDNA as a probe. Two genomic fragments were subcloned and a 7 kb contiguous stretch of the oil palm genome was sequenced...
Biochem Soc Trans (2000) 28 (5): 531–536.
Published: 01 October 2000
... occurs synchronously, there are well-defined markers for stage-regulated processes and cell lines with specific defects in differentiation have been identified. This combination of tools, combined with the developing Trypanosoma brucei genome database is allowing its underlying controls...