...Anastasia Audrey; Lauren de Haan; Marcel A.T.M. van Vugt; H. Rudolf de Boer Failure of cells to process toxic double-strand breaks (DSBs) constitutes a major intrinsic source of genome instability, a hallmark of cancer. In contrast with interphase of the cell cycle, canonical repair pathways...

... integrity. Increasing evidence indicates that chromatin homeostasis plays a key role in the cellular response to TRCs as well as in the preservation of genome integrity. Indeed, chromatin regulating enzymes are frequently mutated in cancer cells, a common characteristic of which is genome instability...

... proteins to the formed DSBs for repair. DNA repair genome instability Hutchinson–Gilford progeria syndrome (HGPS) lamin A premature aging xeroderma pigmentosum group A (XPA) The aging process represents progressive cellular changes which culminate in death due to accumulated...

..., sometimes these processes do not function correctly, leading to genome instability. Studies of DNA repair and genome instability and their causes and cures were showcased in the 2008 Biochemical Society Annual Symposium. The present article provides a summary of the talks given and the subsequent papers...