... License 4.0 (CC BY) . ciliates DNA elimination genome editing genome integrity genome rearrangement Maintaining genetic information accurately is essential for proper cellular functions. Perturbations impede the evolutionary fitness, through multimodal effects including cancer evolution...

... robust maintenance of genomic integrity. Failure to resolve DNA damage during beta-cell development, therefore, can result in an unhealthy reserve of beta-cells and predispose to diabetes. Yet, the molecular mechanisms safeguarding beta-cell genomic integrity remain poorly understood. Here, we focus...

... lead to the loss of genetic material, improperly repaired DSBs can cause chromosomal aberrations or copy number variations, both of which are associated with cancer [ 1 ]. genome integrity methylation oncohistones © 2024 The Author(s). Published by Portland Press Limited on behalf...

...Jai S. Bhachoo; Alexander J. Garvin The preservation of genome integrity requires specialised DNA damage repair (DDR) signalling pathways to respond to each type of DNA damage. A key feature of DDR is the integration of numerous post-translational modification signals with DNA repair factors...

... 2i/LIF medium has provided solutions to some of these challenges, prolonged culturing of these cells, especially female ESCs, raises concerns related to genome integrity. This review discusses the pivotal role of lipids in genome stability and pluripotency of stem cells. Notably, the introduction...

... observed in cancer genomes and provide examples of how data from different experimental systems complement and support each other. DNA repair genome integrity isogenic lines mutational signature whole genome sequencing © 2023 The Author(s) 2023 This is an open access article published...

...? Do other ZBTB proteins bind any other alternative DNA structures? Has the ZBTB family evolved to safeguard genome integrity by recognizing and remodeling different types of non-B-DNA structures? Several ZBTB family members have specific roles during T-cell development [ 20 ]. It will be interesting...

... The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cell cycle DNA damage response genome instability genome integrity mitosis When...

... Cook ( [email protected] ) 2 7 2021 19 8 2021 31 8 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell cycle DNA replication and recombination genome integrity Animal development begins from a single...

... histone substrates of each of the KDM4 family members. cancer chromatin genome integrity KDM4A KDM4A demethylation activity is achieved similar to other members of the JmjC family. The JmjC domain is located near the N-terminus at residues 142–308 and is accompanied by a JmjN domain...

... in the processing of lamin A with inability of the cell to maintain genomic integrity. Studies have proposed that mutation and altered expression of lamin A impairs DNA repair pathways and leads to improper recruitment of different DNA damage repair proteins like RAD 50, RAD 51 and XPA at the site of double strand...

...Sara Priego Moreno; Agnieszka Gambus DNA replication is a complex process that needs to be executed accurately before cell division in order to maintain genome integrity. DNA replication is divided into three main stages: initiation, elongation and termination. One of the key events during...

... on behalf of the Biochemical Society 2018 cancer DNA replication and recombination DNA synthesis and repair genetic disease genome integrity helicase Although RECQL4 lacks a WH domain, the C-terminal region of the protein is critical for helicase activity [ 2 ]. Nonetheless, the apparent...

..., support telomere maintenance at multiple levels. G4 genome integrity helicase in vivo G-quadruplex (G4) structures can form in DNA and RNA molecules when harboring a specific consensus motif (G ≥3 N 1-7 G ≥3 N 1-7 G ≥3 N 1-7 G ≥3 ). Recently, different in vitro and in vivo...