... for therapeutic interventions. Correspondence: Ramiro E. Verdun ( [email protected] ) or  Lluis Morey ( [email protected] ) 26 6 2024 13 8 2024 27 8 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 genome integrity...

...Jai S. Bhachoo; Alexander J. Garvin The preservation of genome integrity requires specialised DNA damage repair (DDR) signalling pathways to respond to each type of DNA damage. A key feature of DDR is the integration of numerous post-translational modification signals with DNA repair factors...

... 2i/LIF medium has provided solutions to some of these challenges, prolonged culturing of these cells, especially female ESCs, raises concerns related to genome integrity. This review discusses the pivotal role of lipids in genome stability and pluripotency of stem cells. Notably, the introduction...

... observed in cancer genomes and provide examples of how data from different experimental systems complement and support each other. Correspondence: Dmitri Ivanov ( [email protected] ) or Anton Gartner ( [email protected] ) 7 4 2023 22 5 2023 24 5 2023 DNA repair genome...

... discuss the significance and implications of these findings in more detail. DNA methylation epigenome remodeling genome integrity prospermatogonia Z-DNA ZBTB43 Correspondence: Piroska E. Szabó ( [email protected] ) 17 10 2022 14 11 2022 15 11 2022 © 2022...

... genome instability genome integrity mitosis HR involves strand invasion of a RAD51-coated DNA end into an undamaged sister chromatid, in order to allow DNA synthesis with the sister chromatid as a template. When there is second-end capture at the DSB site, these sister chromatids can form...

... Cook ( [email protected] ) 2 7 2021 19 8 2021 31 8 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell cycle DNA replication and recombination genome integrity Animal development begins from a single...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cancer chromatin genome integrity KDM4A Figure 1. KDM4 structural/functional domains. ( A ) Schematic showing the functional...

... conjecture that 53BP1 and lamin connectively impart chemo resistance in ovarian cancer cells ( Figure 6 ). Figure 6. A schematic representation correlating lamin A/C level and DNA damage in context of ovarian cancer. DNA damage response genome integrity lamins ovarian cancer ©...

...Sara Priego Moreno; Agnieszka Gambus DNA replication is a complex process that needs to be executed accurately before cell division in order to maintain genome integrity. DNA replication is divided into three main stages: initiation, elongation and termination. One of the key events during...

... on behalf of the Biochemical Society 2018 cancer DNA replication and recombination DNA synthesis and repair genetic disease genome integrity helicase Conserved amino acid sequences (or motifs) comprising the two conserved RecA-like motor domains within the ATPase core domain have been...

... instability on many levels. For a detailed review on the mechanisms of helicases, see ref. [ 20 ]. Here, we will discuss the helicases which are able to unwind G4 structures in vivo and what the biological consequences of this regulation are. G4 genome integrity helicase in vivo G...