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1-22 of 22
Keywords: glucose
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Articles
Enzymes of sphingolipid metabolism as transducers of metabolic inputs
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1795–1808.
Published: 05 August 2024
... changes, focusing on amino acids (serine and alanine), various fatty acids, choline (and ethanolamine), and glucose. Correspondence: Yusuf A. Hannun ( [email protected] ) © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024...
Articles
Trans-endothelial trafficking of metabolic substrates and its importance in cardio-metabolic disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 507–517.
Published: 22 February 2021
..., accumulating evidence suggests that endothelial cells are also active players in maintaining local metabolic homeostasis, in part, through regulating the supply of metabolic substrates, including lipids and glucose, to energy-demanding organs. Therefore, endothelial dysfunction, in terms of altered trans...
Articles
Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 111–118.
Published: 12 January 2018
...Francis B. Stephens; Kostas Tsintzas The molecular and metabolic mechanisms underlying the increase in insulin sensitivity (i.e. increased insulin-stimulated skeletal muscle glucose uptake, phosphorylation and storage as glycogen) observed from 12 to 48 h following a single bout of exercise...
Articles
Metabolic regulation of natural killer cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 758–762.
Published: 03 August 2015
... glucose availability for maximal effector function. This article will discuss the regulation of cellular metabolism in NK cells as compared with that of T lymphocytes and discuss the implications for NK cell responses to viral infection and cancer. 1 email [email protected] 12 5 2015...
Articles
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
... the ETC, partially reducing O 2 to produce O 2 •− . Both T1DM and T2DM are diagnosed according to various categories of hyperglycaemia, as determined by the measurement of blood glucose concentrations. In addition to direct blood glucose measurements, HbA 1c (glycated haemoglobin) is used...
Articles
Glucolipotoxicity of the pancreatic β-cell: myth or reality?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 901–904.
Published: 19 September 2008
...Vincent Poitout The glucolipotoxicity hypothesis postulates that chronically elevated levels of glucose and fatty acids adversely affect pancreatic β-cell function and thereby contribute to the deterioration of insulin secretion in Type 2 diabetes. Whereas ample experimental evidence in in vitro...
Articles
Amino acid metabolism, insulin secretion and diabetes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
...P. Newsholme; K. Bender; A. Kiely; L. Brennan In addition to the primary stimulus of glucose, specific amino acids may acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Mitochondrial metabolism is crucial for the coupling of glucose, alanine...
Articles
Insulin secretion in health and disease: genomics, proteomics and single vesicle dynamics
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (2): 247–250.
Published: 20 March 2006
.... 1 To whom correspondence should be addressed, at Department of Biochemistry, School of Medical Sciences, University of Bristol (email [email protected] ). 12 10 2005 © 2006 The Biochemical Society 2006 β-cell genomics glucose insulin secretion Type II (non-insulin...
Articles
Small molecule glucokinase activators as novel anti-diabetic agents
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (2): 371–374.
Published: 01 April 2005
...B. Leighton; A. Atkinson; M.P. Coghlan The monomeric enzyme GK (glucokinase) has a low affinity for glucose and, quantitatively, is largely expressed in the liver and pancreatic β-cells, playing a key ‘glucose sensing’ role to regulate hepatic glucose balance and insulin secretion. Mutations of GK...
Articles
Sugar sensing and signalling networks in plants
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 269–271.
Published: 01 February 2005
...F. Rolland; J. Sheen Plant sugar signalling operates in a complex network with plant-specific hormone signalling pathways. Hexokinase was identified as an evolutionarily conserved glucose sensor that integrates light, hormone and nutrient signalling to control plant growth and development. 1...
Articles
Glucose modulation of cell size in yeast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 294–296.
Published: 01 February 2005
...M. Vanoni; R.L. Rossi; L. Querin; V. Zinzalla; L. Alberghina Saccharomyces cerevisiae cells grown in glucose have larger average size than cells grown in ethanol. Besides, yeast must reach a carbon source-modulated critical cell size in order to enter S phase at Start. This control is of outmost...
Articles
Glucose sensing through the Hxk2-dependent signalling pathway
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 265–268.
Published: 01 February 2005
...F. Moreno; D. Ahuatzi; A. Riera; C.A. Palomino; P. Herrero In this work, we describe the hexokinase 2 (Hxk2) signalling pathway within the yeast cell. Hxk2 and Mig1 are the two major factors of glucose repression in Saccharomyces cerevisiae . The functions of both proteins have been extensively...
Articles
Glucokinase and glucose homeostasis: proven concepts and new ideas
Available to PurchaseD. Zelent, H. Najafi, S. Odili, C. Buettger, H. Weik-Collins, C. Li, N. Doliba, J. Grimsby, F.M. Matschinsky
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 306–310.
Published: 01 February 2005
...D. Zelent; H. Najafi; S. Odili; C. Buettger; H. Weik-Collins; C. Li; N. Doliba; J. Grimsby; F.M. Matschinsky The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing β-cells. GK has thermodynamic, kinetic, regulatory...
Articles
Glucose as a hormone: receptor-mediated glucose sensing in the yeast Saccharomyces cerevisiae
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 247–252.
Published: 01 February 2005
...M. Johnston; J.-H. Kim Because glucose is the principal carbon and energy source for most cells, most organisms have evolved numerous and sophisticated mechanisms for sensing glucose and responding to it appropriately. This is especially apparent in the yeast Saccharomyces cerevisiae , where...
Articles
Analysis of insulin signalling by RNAi-based gene silencing
Available to PurchaseQ.L. Zhou, J.G. Park, Z.Y. Jiang, J.J. Holik, P. Mitra, S. Semiz, A. Guilherme, A.M. Powelka, X. Tang, J. Virbasius, M.P. Czech
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 817–821.
Published: 26 October 2004
...Q.L. Zhou; J.G. Park; Z.Y. Jiang; J.J. Holik; P. Mitra; S. Semiz; A. Guilherme; A.M. Powelka; X. Tang; J. Virbasius; M.P. Czech Using siRNA-mediated gene silencing in cultured adipocytes, we have dissected the insulin-signalling pathway leading to translocation of GLUT4 glucose transporters...
Articles
Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (1): 83–85.
Published: 01 February 2004
...) uptake in cardiac myocytes from young adult obese Zucker rats is markedly increased, but insensitive to insulin. Basal and insulin-induced glucose uptake rates in these myocytes are not changed, suggesting that during the development from obesity to hyperglycaemic Type II diabetes, alterations in cardiac...
Articles
Mass spectrometric analysis of glucose-modified ribonuclease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1426–1427.
Published: 01 December 2003
...W.E. Cotham; D.J.S. Hinton; T.O. Metz; J.W.C. Brock; S.R. Thorpe; J.W. Baynes; J.M. Ames RNase A (1 mM) was incubated with glucose (0.4 M) at 37°C for up to 14 days in phosphate buffer (0.2 M, pH 7.4), digested with trypsin and analysed by LC-MS. The major sites of fructoselysine formation were Lys...
Articles
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1143–1151.
Published: 01 December 2003
...M.J. Holness; M.C. Sugden PDC (pyruvate dehydrogenase complex) catalyses the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle. Regulation of PDC determines and reflects substrate preference and is critical to the ‘glucose–fatty acid cycle’, a concept...
Articles
AMP-activated protein kinase, super metabolic regulator
Available to PurchaseB.E. Kemp, D. Stapleton, D.J. Campbell, Z.-P. Chen, S. Murthy, M. Walter, A. Gupta, J.J. Adams, F. Katsis, B. van Denderen, I.G. Jennings, T. Iseli, B.J. Michell, L.A. Witters
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 162–168.
Published: 01 February 2003
..., a Biochemical Society-sponsored meeting held at University of Dundee, Scotland, 12–14 September 2002 10 September 2002 Copyright 2003 Biochemical Society 2003 AMP-activated protein kinase metabolism cholesterol exercise fatty acid glucose Abbreviations used: AMPK, AMP...
Articles
Role of AMP-activated protein kinase in the regulation of gene transcription
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 307–311.
Published: 01 April 2002
... expression, glucose, pancreatic p-cell Abbreviations used: ACC, acetyl-CoA carboxylase; Ada I DN, adenovirus encoding a dominant negative form of the a I -subunit of AMPK; AICAR, 5-aminoimidazole-4-carboxamide riboside: AMPK, AMP-activated protein kinase; FAS, fatty acid synthase; GK, glucokinase; GLUT...
Articles
Uncoupling protein 3 biological activity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (6): 774–777.
Published: 01 November 2001
[email protected] 18 6 2001 © 2001 Biochemical Society 2001 transgenic glucose fibre types UCP, uncoupling protein FFA, free fatty acids Biochemical Society Transactions (200 I) Volume 29, part 6 Uncoupling protein 3 biological activity 1. P. Giacobino' Departement...
Articles
Interplay between insulin and nutrients in the regulation of translation factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 541–547.
Published: 01 August 2001
...; and elongation factor eEF2, which mediates the translocation step of elongation. Control of the last three of these is linked to mTOR (mammalian target of rapamycin). In Chinese hamster ovary cells, regulation of all these proteins by insulin is modulated by the presence of amino acids and/or glucose...