... in mammalian cells, PKBα (Akt1), PKBβ (Akt2) and PKBγ (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development. 1 To whom correspondence should be addressed (email...

...M.S. Patel; L.G. Korotchkina The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation...

... in the activation of the target Rab(s) that is necessary for the translocation step. 21 11 2005 © 2006 The Biochemical Society 2006 AS160 glucose homoeostasis GTPase insulin protein kinase B (PKB) Rab Insulin is the primary hormone that is responsible for the control of glucose...