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Keywords: glutathione
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Articles
Biochem Soc Trans (2020) 48 (5): 2253–2259.
Published: 14 October 2020
... glutathione GPX4 lipid peroxidation Ferroptosis is a form of regulated cell death, which is unique, and defined by its requirement of iron-dependent lipid peroxidation [ 1 ]. Ferroptosis regulation is intertwined with an ever-growing array of metabolic processes, such as amino acid metabolism...
Articles
Biochem Soc Trans (2015) 43 (5): 908–912.
Published: 09 October 2015
...Mark Shepherd The CydDC complex of Escherichia coli is a heterodimeric ATP-binding cassette (ABC) transporter that exports cysteine and glutathione to the periplasm. These reductants are thought to modulate periplasmic redox poise, impacting upon the disulfide folding of periplasmic and secreted...
Articles
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... and mitochondria. ATP-binding cassette (ABC) transporter glutathione haem iron mitochondria oxidative stress Mitochondria of most eukaryote species harbour 2–4 different ABC transporters that belong to the B subfamily of half transporters. The proteins contain an N-terminal transmembrane...
Articles
Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
...Edward E. Schmidt NADPH transfers reducing power from bioenergetic pathways to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR) to support essential reductive systems. Surprisingly, it was recently shown that mouse livers lacking both TrxR1 and GR (‘TR/GR-null’) can sustain redox...
Articles
Biochem Soc Trans (2014) 42 (5): 1286–1290.
Published: 18 September 2014
... of the antioxidant systems. There is extensive literature suggesting that Aβ causes oxidative stress. The level of the major antioxidant in the brain, glutathione (GSH), is a key marker of the redox balance in the cells. Using live-cell imaging of GSH, which allows us to separate the GSH signal from neurons...
Articles
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... to be elevated for several days, which has usually been interpreted to reflect increased ROS production. Levels of the antioxidant molecule GSH (reduced glutathione) are depleted for 1 month or longer following ultra-endurance exercise, suggesting an impaired capacity to cope with ROS. The present paper...
Articles
Biochem Soc Trans (2014) 42 (4): 905–908.
Published: 11 August 2014
... with the oxidation of NADPH by either a glutathione or thioredoxin reductase. Both of these hypotheses suggest the presence of a reductive pathway that channels reducing equivalents through a disulfide–exchange protein that is usually a member of the thioredoxin superfamily. We now know that some members...
Articles
Biochem Soc Trans (2014) 42 (4): 979–984.
Published: 11 August 2014
...Bruce Morgan Glutathione is the most abundant small molecule thiol in nearly all eukaryotes. Whole-cell levels of oxidized (GSSG) and reduced (GSH) glutathione are variable and responsive to genetic and chemical manipulations, which has led to their relative levels being widely used as a marker...
Articles
Biochem Soc Trans (2014) 42 (2): 413–418.
Published: 20 March 2014
.... In the 1930s–1950s, advances were made that characterized the essential aspects of the glyoxalase system that we know today. Karl Lohmann (1898–1978) discovered that glutathione (GSH) was a specific and essential cofactor for methylglyoxal metabolism by the glyoxalase system [ 9 ]. Maurice Jowett and Juda...
Articles
Biochem Soc Trans (2014) 42 (2): 491–494.
Published: 20 March 2014
...Makoto Arai; Naomi Nihonmatsu-Kikuchi; Masanari Itokawa; Naila Rabbani; Paul J. Thornalley Glyoxalase I catalyses the isomerization of the hemithioacetal formed non-enzymatically from methylglyoxal and glutathione to S - D -lactoylglutathione. The activity of glyoxalase I is conventionally measured...
Articles
Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
...-phosphate dehydrogenase GPx glutathione peroxidase Grx glutaredoxin GSNO S-nitrosoglutathione GSR glutathione reductase GSS glutathione synthetase GST glutathione transferase IMS mitochondrial intermembrane space ISC iron–sulfur cluster OMM outer...
Articles
Biochem Soc Trans (2011) 39 (5): 1268–1272.
Published: 21 September 2011
...Lucia Coppo; Pietro Ghezzi Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug...
Articles
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
... ). 2 Present address: Birmingham Dental School, St Chad's Queensway, Birmingham B4 6NN, U.K. 3 Present address: Abbott Laboratories, Abbott Park, IL 60064, U.S.A. 18 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ageing glutathione...
Articles
Biochem Soc Trans (2005) 33 (6): 1397–1398.
Published: 26 October 2005
... expression patterns during lactation and after weaning and the possible functions of GSH in the modulation of these events. 1 To whom correspondence should be addressed (email Juan.R.Vina@uv.es ). 30 6 2005 © 2005 The Biochemical Society 2005 glutathione lactation mammary gland...
Articles
Biochem Soc Trans (2005) 33 (6): 1390–1393.
Published: 26 October 2005
... of protein thiols with the endogenous glutathione pool. Protein glutathionylation and disulphide formation are of significance both for defence against oxidative damage and in redox signalling. As mitochondria are central to both oxidative damage and redox signalling within the cell, these modifications...
Articles
Biochem Soc Trans (2005) 33 (6): 1378–1381.
Published: 26 October 2005
... The Biochemical Society 2005 antioxidant disulphide glutathione glutathionylation redox regulation thiol Aerobic organisms reduce molecular oxygen (O 2 ) to water during respiration. However, the interaction with biological systems also generates intermediate steps in the reduction of O 2...
Articles
Biochem Soc Trans (2004) 32 (5): 655–658.
Published: 26 October 2004
... to regenerate the active-site intra-chain disulphide [ 4 ]. For a number of years, it was believed that the low-molecular mass thiol glutathione was responsible for oxidizing the PDI active sites. However, evidence suggests that this is not the case at least in yeast [ 5 ], in which depletion of glutathione...
Articles
Biochem Soc Trans (2004) 32 (6): 990–993.
Published: 26 October 2004
... discovered a common polymorphism in a part of the glutathione peroxidase 4 gene which corresponds to the 3′-UTR, and our recent results suggest that this single-nucleotide polymorphism has functional and physiological effects, as well as altered frequency in disease. 1 email j.e.hesketh@ncl.ac.uk...
Articles
Biochem Soc Trans (2004) 32 (1): 151–155.
Published: 01 February 2004
... of the intracellular antioxidant glutathione. At high concentrations apoptosis occurs through mechanisms that have yet to be defined in detail. Recent studies have revealed a mechanism through which electrophilic lipids, formed as the reaction products of oxidation, orchestrate these adaptive responses...
Articles
Biochem Soc Trans (2003) 31 (6): 1406–1408.
Published: 01 December 2003
... of exposure to MG is best understood in the Gram-negative bacteria. The major mechanism of protection is the spontaneous reaction of MG with GSH to form hemithiolacetal, followed by detoxification by the glyoxalase system leading to the production of d-lactate. The KefB and KefC glutathione-gated K + efflux...
Articles
Biochem Soc Trans (2003) 31 (6): 1337–1339.
Published: 01 December 2003
...C.M. Jones; A. Lawrence; P. Wardman; M.J. Burkitt Superoxide radicals are produced in trace amounts by the mitochondrial respiratory chain. Most are removed rapidly by superoxide dismutase in the matrix. Superoxide is also known to react with glutathione. Reported values of the rate constant...
Articles
Biochem Soc Trans (2003) 31 (6): 1343–1348.
Published: 01 December 2003
... reactions mediated by methylglyoxal, glyoxal and other α-oxoaldehydes in vivo . 1 e-mail thorp@essex.ac.uk 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 1 September 2003 © 2003 Biochemical Society 2003 glutathione...
Articles
Biochem Soc Trans (2003) 31 (6): 1308–1311.
Published: 01 December 2003
... be addressed (e-mail hans.nohl@vu-wien.ac.at ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 4 July 2003 © 2003 Biochemical Society 2003 ATPase activity bc 1 complex glutathione hydrogen peroxide mitochondria superoxide...
Articles
Biochem Soc Trans (2002) 30 (4): 755–758.
Published: 01 August 2002
... of the antioxidant glutathione, indicating the role of oxidative stress in their toxicity. K562 cells loaded with eicosapentaenoic acid, a fatty acid particularly susceptible to oxidation, were also more sensitive to the toxic effects of the Fe complexes, and toxicity was proportional to lipid peroxidation. Thus...
Articles
Biochem Soc Trans (2001) 29 (6): 717–722.
Published: 01 November 2001
...G. J. McBean; J. Flynn The transport of l -cystine into cells of the mammalian brain is an essential step in the supply of cysteine for synthesis of the antioxidant glutathione. Uptake of l cystine in rat brain synaptosomes occurs by three mechanisms that are distinguishable on the basis...
Articles
Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
Articles
Biochem Soc Trans (1982) 10 (2): 82–84.
Published: 01 April 1982
...BRIAN KETTERER; DENNIS BEALE; DAVID MEYER © 1982 Biochemical Society 1982 GSH glutathione 82 BIOCHEMICAL SOCIETY TRANSACTIONS glutathione S-transferases where the conjugates may be biologically important molecules. The slow-reacting substance of anaphylaxis was originally described...