... analysis. Stage III : Online separation and fragmentation-based identification of glycopeptides. Stage IV : Bioinformatic (operator supervised) analyses of the data generated and integration of orthogonal data (e.g. glycomics data) to perform qualitative and quantitative glycoproteome profiling. Stage V...

... under a transformative agreement with JISC. cell engineering erythropoietin glycomics glycoproteomics glycosylation monoclonal antibodies Advances in glycoengineering are increasingly providing opportunities for modulating the properties and functions of recombinant biotherapeutics...

...Kay-Hooi Khoo The nature of protein glycosylation renders cellular glycomics a very challenging task in having to deal with all the disparate glycans carried on membrane glycoproteins. Rapid mapping by mass spectrometry analysis provides only a coarse sketch of the glycomic complexity based...

... concentrations. The shotgun glycan microarray is then interrogated with a biologically relevant GBP and the corresponding glycan ligands can be retrieved from the TGL for detailed structural analysis and further functional analysis. Shotgun glycomics extended the defined glycan microarray to a discovery platform...

... requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other ‘-omics’ approaches to define...

... Society 2006 anti-inflammatory drug chemokine mutant glycomics glycosaminoglycan G-protein-coupled receptor (GPCR) protein engineering Chemokines induce cell migration and activation by binding to specific cell surface, seven-transmembrane-spanning GPCRs (G-protein-coupled receptors...