... making glycoproteins important diagnostic and prognostic biomarker candidates and therapeutic targets. Glycoproteomics, the study of glycans and their carrier proteins in a system-wide context, is becoming a powerful tool in glycobiology that enables the functional analysis of protein glycosylation...

... glycomics glycoproteomics glycosylation monoclonal antibodies The role of glycan composition and structure in modulating the effector function of glycoproteins needs to be elucidated in order to determine a priori which glycoform is desirable for a specific biotherapeutic. The intimate structure...

... the much-needed balance in sensitivity, structural precision and analytical throughput to match advances in other omics. Correspondence: K.-H. Khoo ( [email protected] ) Figure 1. Conceptual framework for a glycotope-centric cellular glycomics and glycoproteomics. The ideal workflow...

...Anastasia Chernykh; Rebeca Kawahara; Morten Thaysen-Andersen Facilitated by advances in the separation sciences, mass spectrometry and informatics, glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling new insights into the complex glycoproteome. While...

... have been built in part on the development and application of mass spectrometric technologies to the bacterial glycoproteome. This review highlights recent findings using high sensitivity MS of the large variation of glycans that have been reported on flagellin and pilin proteins of bacteria, using...