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Keywords: glycosaminoglycan
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Articles
Biochem Soc Trans (2018) 46 (2): 371–377.
Published: 09 March 2018
... that significantly decreases the susceptibility to several bacterial infections, suggesting that subversion of Sdc1 is an important virulence strategy. HS glycosaminoglycan (GAG) chains of cell surface Sdc1 promote bacterial pathogenesis by facilitating the attachment of bacteria to host cells. Engagement of cell...
Articles
Biochem Soc Trans (2016) 44 (1): 109–115.
Published: 09 February 2016
.... They have been shown to be involved in key biological processes such as cell signalling, hormone regulation, degradation of sulfated glycosaminoglycans and glycolipids [ 17 ]. Contrary to Types II and III sulfatases, a metallic cofactor is not directly involved in catalysis, although calcium or magnesium...
Articles
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... embryonic stem cell glycosaminoglycan heparan sulfate signalling A key component for the ability of a cell to respond specifically to extrinsic signals is the sugar polymer HS (heparan sulfate). The GAG (glycosaminoglycan) HS is synthesized attached to protein cores, generating HSPGs (heparan...
Articles
Biochem Soc Trans (2011) 39 (1): 383–387.
Published: 19 January 2011
... with particular patterns of GAG (glycosaminoglycan) expression. For example, different HS epitopes are synthesized during neural or mesodermal lineage formation. Cell lines mutant for various components of the HS biosynthetic pathway are selectively impaired in their differentiation, with lineage-specific effects...
Articles
Biochem Soc Trans (2007) 35 (1): 47–49.
Published: 22 January 2007
... Copyright Clearance Center. 16 10 2006 © 2007 The Biochemical Society 2007 antisense oligonucleotide (AON) glycosaminoglycan lipoplex non-viral ocular gene transfer PEGylation vitreous Ocular gene therapy may offer new hope for severe eye diseases such as retinitis...
Articles
Biochem Soc Trans (2006) 34 (3): 422–426.
Published: 22 May 2006
... (glycosaminoglycan) chains are attached. The GAGs are long, linear, sulphated and highly charged heterogeneous polysaccharides that are expressed throughout the body in different forms depending on the developmental or pathological state of the organ/organism. Mechanistically, the GAG interaction is thought...
Articles
Biochem Soc Trans (2006) 34 (3): 446–450.
Published: 22 May 2006
... the protease network through inhibition of plasmin. TSG-6 binds a wide range of GAGs (glycosaminoglycans) [i.e. HA (hyaluronan), chondroitin 4-sulphate, dermatan sulphate, heparin and heparan sulphate] as well as a variety of protein ligands, where these interactions can influence the activities of TSG-6...
Articles
Biochem Soc Trans (2006) 34 (3): 435–437.
Published: 22 May 2006
...H. Potzinger; E. Geretti; B. Brandner; V. Wabitsch; A.-M. Piccinini; A. Rek; A.J. Kungl The interaction of chemokines and GAGs (glycosaminoglycans) on endothelial surfaces is a crucial step for establishing a chemotactic gradient which leads to the functional presentation of chemokines...
Articles
Biochem Soc Trans (2006) 34 (3): 409–413.
Published: 22 May 2006
...B. Mulloy; C.C. Rider The defining characteristic of the glycoproteins known as proteoglycans is the presence of O-linked acidic polysaccharides known as GAGs (glycosaminoglycans). The backbone of these linear polysaccharides is a repeating disaccharide, comprising N -acetyl hexosamine alternating...
Articles
Biochem Soc Trans (2004) 32 (2): 366–377.
Published: 01 April 2004
... for which small-molecule-receptor antagonists have been developed. In addition to the high-affinity receptor interaction, chemokines have an in vivo requirement to bind to GAGs (glycosaminoglycans) in order to mediate directional cell migration. Prevention of the GAG interaction has been shown...
Articles
Biochem Soc Trans (2003) 31 (2): 337–339.
Published: 01 April 2003
... factor (GDNF) glycosaminoglycan growth factor heparan sulphate 2-O-sulphotransferase heparin Abbreviations used: FGF, fibroblast growth factor; GDNF, glial-cell-line-derived neurotrophic factor; GFRα1, GDNF receptor α1; HS2OST, heparan sulphate 2-O-sulphotransferase. Sulphotransferases...
Articles
Biochem Soc Trans (2003) 31 (2): 352–353.
Published: 01 April 2003
... with an equilibrium dissociation constant ( K d ) of approx. 1 nM. An Erk activation assay also demonstrated stimulation of the MAP kinase pathway downstream of the Met receptor following addition of both HGF/SF and ascidian DS to the glycosaminoglycan-deficient CHO-745 mutant cell line. Furthermore, the activation...
Articles
Biochem Soc Trans (2002) 30 (4): 565–569.
Published: 01 August 2002
... glycosaminoglycans can act as important cofactors or modulators of PrP-res formation in vivo . In an effort to develop therapeutics, the antimalarial drug quinacrine was identified as an inhibitor of PrP-res formation in scrapie-infected cell cultures. Confirmation of the latter result by others has led...