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Keyword: glycosylation
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Articles
Biochem Soc Trans (2019) BST20170410.
Published: 14 November 2019
... lectin receptors. These lectins may contribute to initial recognition of bacterial glycans, thus providing an early defence mechanism against bacterial infections, but they may also be exploited by bacteria to escape immune responses. In this review, we will first exemplify bacterial glycosylation...
Articles
Biochem Soc Trans (2018) 46 (3): 691-698.
Published: 21 May 2018
... 30 disulfide bonds and around a 100 N-linked glycosylation sites, and are functionally dependent on protease cleavage within the secretory system. The resulting mature structure adopts a compact fold with the vast majority of its surface obscured by a protective shield of glycans which can be...
Articles
Biochem Soc Trans (2018) 46 (2): 343-350.
Published: 09 March 2018
...Maria C. Rodriguez Benavente; Pablo Argüeso Glycosylation is a major form of enzymatic modification of organic molecules responsible for multiple biological processes in an organism. The biosynthesis of glycans is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying...
Articles
Biochem Soc Trans (2017) 45 (2): 389-399.
Published: 13 April 2017
...); published by Portland Press Limited on behalf of the Biochemical Society 2017 adhesins gastrointestinal mucins glycosylation microbiota pathogens The number of bacteria constituting the human microbiota is nearly the same as the number of cells in the human body and most of these...
Articles
Biochem Soc Trans (2011) 39 (1): 336-339.
Published: 19 January 2011
...Jane E. Hewitt During the last 10 years it has become apparent that a significant subset of inherited muscular dystrophy is caused by errors in the glycosylation of α-dystroglycan. Many of these dystrophies are also associated with abnormalities of the central nervous system. Dystroglycan has to be...
Articles
Biochem Soc Trans (2011) 39 (1): 370-373.
Published: 19 January 2011
.... Aberrant glycosylation is a hallmark of malignancy and a well-studied class of β1,6-branched oligosaccharides is associated with malignant transformation of rodent and human cells, and poor prognosis in cancer patients. It is evident that increased β1,6 branching significantly contributes to the phenotype...
Articles
Biochem Soc Trans (2011) 39 (1): 388-392.
Published: 19 January 2011
...Eirikur Saeland; Yvette van Kooyk A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute to...
Articles
Biochem Soc Trans (2011) 39 (1): 399-405.
Published: 19 January 2011
... substitutions. What poses an enormous challenge for analytical processing is, at the same time, the basis for the fingerprint-like glycomic profiles of glycoconjugates and cells. What's more, the glycosylation machinery is sensitive to disease manifestations, earning glycan assembly a reputation as a promising...
Articles
Biochem Soc Trans (2011) 39 (1): 327-330.
Published: 19 January 2011
...Jayne E. Telford; Margaret A. Doherty; Tharmala Tharmalingam; Pauline M. Rudd Glycosylation modifications have been reported in a number of disease states and, as a result, there is significant focus on the discovery and development of glycan-based biomarkers. Glyco-biomarkers have the potential to...
Articles
Biochem Soc Trans (2010) 38 (5): 1374-1377.
Published: 24 September 2010
...Li Liu; Jayne E. Telford; Ana Knezevic; Pauline M. Rudd The development of glycoanalytical HPLC-based high-throughput technology has greatly enhanced the study of glycobiology, facilitating the discovery of disease-related solutions and providing an informative view of glycosylation and its...
Articles
Biochem Soc Trans (2010) 38 (5): 1307-1313.
Published: 24 September 2010
...Paul G. Hitchen; Katie Twigger; Esmeralda Valiente; Rebecca H. Langdon; Brendan W. Wren; Anne Dell With glycosylation now firmly established across both Archaeal and bacterial proteins, a wide array of glycan diversity has become evident from structural analysis and genomic data. These discoveries...
Articles
Biochem Soc Trans (2008) 36 (6): 1491-1496.
Published: 19 November 2008
... © 2008 Biochemical Society 2008 glycoprotein glycosylation inflammation lectin malignancy multivalency Biochemical signals can be compared with words which are formed by combinations of letters of an alphabet. The order of the letters (sequence) conveys information, and the theoretical...
Articles
Biochem Soc Trans (2005) 33 (5): 1094-1095.
Published: 26 October 2005
... PrP's N-glycans to the misfolding of the protein. 1 To whom correspondence should be addressed (email frances.wiseman@bbsrc.ac.uk ). 1 7 2005 © 2005 The Biochemical Society 2005 Creutzfeldt–Jacob disease (CJD) glycosylation prion protein folding PrP transmissible...
Articles
Biochem Soc Trans (2004) 32 (1): 33-36.
Published: 01 February 2004
... Society 2004 Alzheimer's disease amyloidogenesis cholesterol glycosylation lovastatin proteolysis β-secretase Abbreviations used: Aβ, β-amyloid; APP, Alzheimer's amyloid precursor protein; APPswe, Swedish mutant of APP; ASP-2, aspartic protease 2; FCS, fetal calf serum; Endo H...