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Keywords: haem
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Articles
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Biochem Soc Trans (2013) 41 (6): 1588–1592.
Published: 20 November 2013
... our current knowledge of the molecular mechanisms involved in the handling of iron by astrocytes. Cultured astrocytes efficiently take up iron as ferrous or ferric iron ions or as haem by specific iron transport proteins in their cell membrane. In addition, astrocytes accumulate large amounts of iron...
Articles
Biochem Soc Trans (2012) 40 (6): 1217–1221.
Published: 21 November 2012
... 6 2012 © 2012 The Authors Journal 2012 cytochrome electrochemistry haem mineral reduction quinone Shewanella oneidensis The gammaproteobacterium Shewanella oneidensis MR-1 colonizes various changeable marine and freshwater environments. This capability is underpinned...
Articles
Biochem Soc Trans (2012) 40 (6): 1268–1273.
Published: 21 November 2012
... length. In the present paper, DmsE is further characterized via protein film voltammetry, revealing that the electrochemistry of the DmsE haem cofactors display macroscopic potentials lower than those of MtrA by 100 mV. It is possible this tuning of the redox potential of DmsE is required to shuttle...
Includes: Supplementary data
Articles
Biochem Soc Trans (2012) 40 (3): 501–507.
Published: 22 May 2012
... and spectroscopic studies. The present paper also describes studies of two haem-regulated systems that involve a principle of metabolic regulation interlinking redox, haem and CO. Recent studies with HO2 (haem oxygenase-2), a K + ion channel (the BK channel) and a nuclear receptor (Rev-Erb) demonstrate...
Articles
Biochem Soc Trans (2009) 37 (2): 373–377.
Published: 20 March 2009
... and the conversion of L -arginine into N ω -hydroxo-arginine. Although NOS enzymes show many structural similarities to cytochrome P450 enzymes, it has long been anticipated that therefore they should have a similar catalytic cycle where molecular oxygen binds to a haem centre and is converted into an Fe(IV)-oxo...
Articles
Biochem Soc Trans (2009) 37 (2): 408–412.
Published: 20 March 2009
...Sara A. Rafice; Nishma Chauhan; Igor Efimov; Jaswir Basran; Emma Lloyd Raven The family of haem dioxygenases catalyse the initial oxidative cleavage of L -tryptophan to N -formylkynurenine, which is the first, rate-limiting, step in the L -kynurenine pathway. In the present paper, we discuss...
Articles
Biochem Soc Trans (2008) 36 (6): 1239–1241.
Published: 19 November 2008
... both ferric reductase activity and stimulate uptake of 59 Fe. An additional increase in cupric reductase activity was found in MDCK (Madin–Darby canine kidney) cells expressing Dcytb. Expression and purification of Dcytb in insect cells reveals that Dcytb is a di-haem protein and that the haems...
Articles
Biochem Soc Trans (2008) 36 (6): 1103–1105.
Published: 19 November 2008
... oxidase haem magnetic circular dichroism (MCD) Sitting some 60 miles south of UEA (University of East Anglia), I have watched with great admiration the growth and development of the CMSB (Centre for Metalloprotein Spectroscopy and Biology) over the past 30 years. That it has grown during...
Articles
Biochem Soc Trans (2008) 36 (6): 1106–1111.
Published: 19 November 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 abzyme de novo protein design haem maquette protein engineering water penetration The generation of de novo enzymes offers the prospect of harnessing the impressive power and range of chemistry of natural enzymes...
Articles
Biochem Soc Trans (2008) 36 (6): 1149–1154.
Published: 19 November 2008
...Brian R. Crane Mammalian NOSs (nitric oxide synthases) are haem-based monoxygenases that oxidize the amino acid arginine to the intracellular signal and protective cytotoxin nitric oxide (NO). Certain strains of mostly Gram-positive bacteria contain homologues of the mammalian NOS catalytic domain...
Articles
Biochem Soc Trans (2008) 36 (6): 1120–1123.
Published: 19 November 2008
...Sarah J. Thackray; Christopher G. Mowat; Stephen K. Chapman The haem proteins TDO (tryptophan 2,3-dioxygenase) and IDO (indoleamine 2,3-dioxygenase) are specific and powerful oxidation catalysts that insert one molecule of dioxygen into L -tryptophan in the first and rate-limiting step...
Articles
Biochem Soc Trans (2008) 36 (6): 1124–1128.
Published: 19 November 2008
...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...
Articles
Biochem Soc Trans (2008) 36 (6): 1138–1143.
Published: 19 November 2008
... cases, death. The Isd (iron-regulated surface determinant) proteins expressed by S. aureus and select other bacteria are anchored to the bacterial cell wall and membrane and are involved in extracting haem from haemoglobin as an iron source. Our knowledge of the overall haem-scavenging mechanism...
Articles
Biochem Soc Trans (2006) 34 (6): 1178–1182.
Published: 25 October 2006
...-ordinated) species on reduction of the haem iron in the absence of a P450 substrate. The accessory flavoprotein and iron–sulfur proteins required to drive P450 catalysis are also discussed, providing an overview of the current state of knowledge of Mtb P450 redox systems. 1 To whom correspondence...
Articles
Biochem Soc Trans (2006) 34 (6): 1223–1227.
Published: 25 October 2006
... The Biochemical Society 2006 allene oxide synthase cytochrome P450 subfamily 74 (CYP74) detergent micelle haem hydroperoxide lyase oxylipin Members of the CYP74 (cytochrome P450 subfamily 74) have not been studied extensively. CYP74 enzymes are very different from classical P450 enzymes...
Articles
Biochem Soc Trans (2006) 34 (6): 1173–1177.
Published: 25 October 2006
... correspondence should be addressed (email Andrew.Munro@Manchester.ac.uk ). 26 6 2006 © 2006 The Biochemical Society 2006 Bacillus BM3 CYP102 electron transfer flavocytochrome haem P450s (cytochromes P450) are oxygenases known for their catalytic versatility and the breadth...
Articles
Biochem Soc Trans (2006) 34 (1): 91–93.
Published: 20 January 2006
...J.W.A. Allen; S.J. Ferguson c -Type cytochromes are characterized by covalent attachment of haem to protein through thioether bonds between the vinyl groups of the haem and the thiols of a Cys-Xaa-Xaa-Cys-His motif. Proteins of this type play crucial roles in the biochemistry of the nitrogen cycle...
Articles
Biochem Soc Trans (2006) 34 (1): 133–135.
Published: 20 January 2006
... and after colonization of a human host. 1 To whom correspondence should be addressed (email j.butt@uea.ac.uk ). 5 10 2005 © 2006 The Biochemical Society 2006 cytochrome c nitrite reductase Escherichia coli haem inhibitor of cytochrome c nitrite reductase protein film...
Articles
Biochem Soc Trans (2006) 34 (1): 150–151.
Published: 20 January 2006
...J.W.A. Allen; S.J. Ferguson c -Type cytochromes are characterized by covalent attachment of haem to protein through thioether bonds between the vinyl groups of the haem and the thiols of a CXXCH motif. Proteins of this type play crucial roles in the biochemistry of the nitrogen cycle. Many Gram...
Articles
Biochem Soc Trans (2005) 33 (4): 737–742.
Published: 01 August 2005
...M. Moulin; A.G. Smith Plant tetrapyrroles are the most abundant biomolecules on the earth and are cofactors of many apoproteins essential for plant function. The four end-products sirohaem, chlorophyll, haem and phytochromobilin are synthesized by a common branched pathway, which is tightly...
Articles
Biochem Soc Trans (2005) 33 (4): 792–795.
Published: 01 August 2005
...J.M. Stevens; T. Uchida; O. Daltrop; S.J. Ferguson Haem (Fe-protoporphyrin IX) is a cofactor found in a wide variety of proteins. It confers diverse functions, including electron transfer, the binding and sensing of gases, and many types of catalysis. The majority of cofactors are non-covalently...
Articles
Biochem Soc Trans (2005) 33 (1): 137–140.
Published: 01 February 2005
... 2005 cytochrome c haem magnetic CD (MCD) nitrite reductase oxidoreductase protein-film voltammetry (PFV) Bacterial nitrite reduction can be coupled with energy conservation by three distinct types of enzyme: cytochrome cd 1 nitrite reductases, copper nitrite reductases...
Articles
Biochem Soc Trans (2005) 33 (1): 145–146.
Published: 01 February 2005
...J.W.A. Allen; M.L. Ginger; S.J. Ferguson c -type cytochromes contain haem covalently attached to protein by thioether bonds formed post-translationally and requiring a dedicated biogenesis apparatus. Three biogenesis systems, found in different cell types, are well known. Here we discuss emerging...
Articles
Biochem Soc Trans (2005) 33 (1): 149–151.
Published: 01 February 2005
...A. Crow; N.E. Le Brun; A. Oubrie Numerous bacterial proteins involved in the nitrogen cycle, and other processes, require c -type haem as a cofactor. c -type cytochromes are formed by covalent attachment of haem to the conserved CXXCH motif. Here, we briefly review what is presently known about...
Articles
Biochem Soc Trans (2003) 31 (3): 553–557.
Published: 01 June 2003
.... It contains a 5-coordinate (5c) His-ligated haem that shares spectroscopic and ligand-binding properties with the haem group in the sensory domain of soluble guanylate cyclase (sGC). The latter is an extremely important enzyme involved in the control of vasodilation and blood clotting. Curiously, the enzyme...
Articles
Biochem Soc Trans (2002) 30 (4): 658–662.
Published: 01 August 2002
... in bioremediation. The wide variety of respiratory substrates for Shewanella is correlated with the evolution of several multi-haem membrane-bound, periplasmic and outer-membrane c -type cytochromes. The 21 kDa c -type cytochrome CymA of the freshwater strain Shewanella oneidensis MR-1 has an N-terminal membrane...
Articles
Biochem Soc Trans (2002) 30 (4): 579–584.
Published: 01 August 2002
... 3 2002 © 2002 Biochemical Society 2002 catalytic mechanism crystal structure haem tetrapyrrole biosynthesis Tetrapyrroles: Their Life, Birth and Death Bioenergetics Group Colloquium Organized by P. Heathcote and M. J. Warren (School of Biological Sciences, Queen Mary, University...
Articles
Biochem Soc Trans (2001) 29 (2): 105–111.
Published: 01 May 2001
...E. Lloyd Raven; A. Celik; P. M. Cullis; R. Sangar; M. J. Sutcliffe Understanding the catalytic versatility of haem enzymes, and in particular the relationships that exist between different classes of haem-containing proteins and the mechanisms by which the apo-protein structure controls chemical...