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Keywords: heart failure
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Biochem Soc Trans (2023) 51 (2): 715–724.
Published: 04 April 2023
... targets for several cardiovascular disorders including heart failure (HF) such as beta-adrenergic receptor (βAR) blockers and angiotensin II receptor (AT1R) antagonists. The activity of GPCRs are finely regulated by GPCR kinases (GRKs), which phosphorylate agonist-occupied receptors and start the process...
Biochem Soc Trans (2022) 50 (1): 439–446.
Published: 07 January 2022
... BY) . chronic kidney disease fibroblast growth factors heart failure hypertension phosphate small molecules Plasma phosphate (P i ) is tightly controlled in the range from 0.9 to 1.45 mmol L −1 in healthy adults [ 1 ], and requires a concerted interplay between intestinal uptake, storage/release...
Biochem Soc Trans (2020) 48 (5): 1905–1916.
Published: 14 October 2020
... 2020 19 9 2020 22 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 corin heart failure hypertension protease domains Atrial natriuretic peptide (ANP)-mediated vasodilation and natriuresis are important mechanisms...
Biochem Soc Trans (2016) 44 (5): 1549–1560.
Published: 19 October 2016
...Lisha Ma Chronic heart failure is a common consequence of various heart diseases. Mechanical force is known to play a key role in heart failure development through regulating cardiomyocyte hypertrophy. In order to understand the complex disease mechanism, this article discussed a multi-disciplinary...
Biochem Soc Trans (2016) 44 (1): 25–34.
Published: 09 February 2016
... enhanced in polyP-depleted cells demonstrating that polyP protects cardiac myocytes against enhanced ROS formation. Furthermore, polyP concentration was dynamically changed during activation of the mitochondrial respiratory chain and stress conditions such as ischaemia/reperfusion (I/R) and heart failure...
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
.... Consistent with this, a cAMP-responsive signalling complex that includes Epac1 and PDE4D3 has been identified in cardiac myocytes [ 28 ]. cAMP cardiac disease exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor (GPCR) heart failure phosphodiesterase cAMP...
Biochem Soc Trans (2012) 40 (1): 11–14.
Published: 19 January 2012
...Alessandra Stangherlin; Manuela Zaccolo cAMP and cGMP signalling pathways are common targets in the pharmacological treatment of heart failure, and often drugs that modulate the level of these second messengers are simultaneously administered to patients. cGMP can potentially affect cAMP levels...
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
... of cAMP can be altered in cardiovascular and brain disorders such as heart failure and AD (Alzheimer's disease). PKA (protein kinase A) and cyclic-nucleotide-gated channels were thought to be the only two direct effectors of cAMP, until the identification of Epac (exchange protein directly activated...
Biochem Soc Trans (2006) 34 (4): 502–503.
Published: 21 July 2006
.... Mol. Cell. Biol. 1999 19 6286 6296 11 Dodge K.L. Khouangsathiene S. Kapiloff M.S. Mouton R. Hill E.V. Houslay M.D. Langeberg L.K. Scott J.D. EMBO J. 2001 20 1921 1930 cAMP compartmentalization heart failure phosphodiesterase 3B (PDE3B...