... nut to crack, remaining an open question nowadays. Here we revisit the highlights on the study of heat and cold sensing in thermoTRP channels in the light of the structural data that has emerged during recent years. heat capacity ion channel gating temperature sensing thermoTRP channels...

...; 1 atm=101.325 kPa) to dilute aqueous solutions of proteins or other biomolecules. We show here how this can be related to changes in solvation/hydration during protein–protein and protein–ligand interactions. Measurements of ‘anomalous’ heat capacity effects in a wide variety of biomolecular...