...Yannic Becker; Hermann Haller Heparan sulfate (HS) proteoglycans are life-supporting proteins comprising a core protein to which one or more HS glycan chains are covalently bound. HS proteoglycans act as binding sites for circulating cells and molecules, allow gradient formation, and provide local...

... of intermediate sulfation (NS/NA domain) that interject unmodified regions (NA domain) [ 41 , 42 ]. Figure 1. HS structure and modification. HPSE, heparanase; SULF, sulfatase. drug discovery and design heparan sulfate host–pathogen interactions Leishmania parasitology proteoglycan...

..., manifest an obligate dependence on heparan sulfate (HS) for their biological activity. This mandatory requirement of angiogenic cytokines for HS identifies HS as a potential target for novel anti-angiogenic therapy. Targeting multiple angiogenic cytokines with HS mimetics may represent an opportunity...

...Giulia De Rossi; James R. Whiteford Syndecans are multifunctional heparan sulfate proteoglycans (HSPGs) with roles in cell adhesion, migration, receptor trafficking and growth-factor interactions and signalling. Studies using syndecan null animals have revealed limited roles for syndecans during...

... to function co-operatively. HS (heparan sulfate) is a highly sulfated linear polysaccharide that resides at the pericellular cell–matrix interface where it dictates the binding and activity of a large number of proteins, including growth factors and morphogens such as members of the FGF (fibroblast growth...

...Raymond A.A. Smith; Kate Meade; Claire E. Pickford; Rebecca J. Holley; Catherine L.R. Merry ES (embryonic stem) cell differentiation is dependent on the presence of HS (heparan sulfate). We have demonstrated that, during differentiation, the evolution of specific cell lineages is associated...

... To whom correspondence should be addressed (email [email protected] ). 4 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycobiology glycosaminoglycan (GAG) heparan sulfate lipopolysaccharide (LPS) O-linked β- N -acetylglucosamine (O-GlcNAc...

... the molecular code of the heparanome. 1 email [email protected] 16 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycomics heparanome heparan sulfate interactome systems biology ATIII antithrombin III FGF fibroblast growth...

... exert their effects by activating receptors of the Robo (Roundabout) family, which resemble cell adhesion molecules in their ectodomains and have large, mainly unstructured cytosolic domains. HS (heparan sulfate) is required for Slit–Robo signalling. The hallmark of Slit proteins is a tandem of four LRR...