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Keywords: heparin
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Coronavirus
Biochem Soc Trans (2023) 51 (3): 1361–1375.
Published: 09 June 2023
... of COVID-19 infection and of more severe disease, and the experimental evidence that AAT inhibits cell surface transmembrane protease 2 (TMPRSS2) — a host serine protease required for SARS-CoV-2 entry into cells — and that this inhibition may be augmented by heparin. We also elaborated on the panoply...
Articles
Biochem Soc Trans (2010) 38 (4): 1006–1011.
Published: 26 July 2010
... compilation © 2010 Biochemical Society 2010 Alzheimer's disease heparin nuclear magnetic resonance spectroscopy (NMR spectroscopy) phosphorylation tau Deregulation of tau phosphorylation has been linked to the pathogenesis of AD (Alzheimer's disease). The aggregated tau in PHFs (paired...
Articles
Biochem Soc Trans (2006) 34 (3): 422–426.
Published: 22 May 2006
... by the fact that the acidic chemokines CCL3 and CCL4 bind GAGs [ 20 ]. The XBBXBX and XBBBXXBX motifs, where B is a basic amino acid, are common heparin-binding motifs for several proteins [ 21 ]. Indeed, the common heparin-binding motif for several chemokines has been described as a classical BBXB motif...
Articles
Biochem Soc Trans (2006) 34 (3): 409–413.
Published: 22 May 2006
... effects depend on the resulting sequences. Some proteins, for example antithrombin, have highly specific sequence requirements for their GAG ligand [in this case heparin or HS (heparan sulphate)]; others, for example the fibroblast growth factors, are less demanding. GAGs, in particular HS, play a role...
Articles
Biochem Soc Trans (2006) 34 (3): 458–460.
Published: 22 May 2006
..., and therefore have important roles in morphogenesis, organogenesis, tissue maintenance and wound healing. Thus far, around one-quarter of these cytokines have been shown to bind to heparin and heparan sulphate. Well-established examples are the TGF-β isoforms 1 and 2, and the BMPs (bone morphogenetic proteins...
Articles
Biochem Soc Trans (2006) 34 (3): 442–445.
Published: 22 May 2006
... factor and receptor bind to HS, and HS or heparin is an absolute requirement for full signalling. The FGF signalling system has been extremely well structurally characterized, and details of each interaction involved in forming a ternary complex of FGF–FGFR–heparin have been elucidated. Recent work has...
Articles
Biochem Soc Trans (2006) 34 (3): 431–434.
Published: 22 May 2006
...M. Forster; B. Mulloy The identification of heparin-binding sites is important for understanding the physiological function of many secreted proteins. Most of the experimental techniques for mapping these sites do not define them to atomic resolution. The use of automated docking methods can aid...
Articles
Biochem Soc Trans (2006) 34 (3): 414–417.
Published: 22 May 2006
... the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met–HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2...
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Articles
Biochem Soc Trans (2002) 30 (6): 978–982.
Published: 01 November 2002
... of complement control protein domains (CCPs). Using homology-based computer modelling and mutagenesis of recombinant proteins we have localized binding sites for several ligands of C4BP: complement factor C4b, heparin and vitamin K-dependent anticoagulant protein S (PS). We found that C4b requires CCP1–3...