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Keywords: heterochromatin
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Biochem Soc Trans (2021) 49 (5): 2241–2251.
Published: 08 September 2021
... are transcriptionally activated. This transcription activation depends in part on genomic location, such that expression of pericentromeric LTR retrotransposons is limited by constitutive heterochromatin, whereas euchromatic ATCOPIA elements can be transcriptionally activated by developmental or environmental cues...
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Biochem Soc Trans (2020) 48 (5): 1967–1978.
Published: 08 September 2020
... DNA into nucleosomal arrays, which are further organized into more condensed heterochromatin and more open euchromatin by chromatin modifier proteins [ 19–24 ]. Heterochromatin protein 1 (HP1) and Polycomb Repressive Complex 1 (PRC1) condense nucleosomal arrays into compact heterochromatin, which...
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Biochem Soc Trans (2013) 41 (6): 1706–1711.
Published: 20 November 2013
... of heterochromatin. The resulting changes in genetic organization, including chromosome loss, increased mutation and loss of heterozygosity, are important contributors to malignant growth. 1 email [email protected] 8 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013...
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Biochem Soc Trans (2013) 41 (6): 1634–1639.
Published: 20 November 2013
...) or sequencing (ChIP-seq) by newly developed MPS (massive parallel sequencing) techniques. This high-throughput approach has allowed for a wide coverage of protein–DNA interactive components of the human epigenome ( http://www.roadmapepigenomics.org ). chromatin fission yeast heterochromatin nuclear...
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Articles
Biochem Soc Trans (2012) 40 (1): 173–178.
Published: 19 January 2012
... and marked relaxation at the DSB site. To date, no studies have shown that HC relaxation occurs specifically at the DSB site. ataxia telangiectasia mutated signalling (ATM signalling) chromatin structure DNA double-strand break repair heterochromatin homologous recombination ribosomal DNA (rDNA...
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Biochem Soc Trans (2011) 39 (6): 1705–1709.
Published: 21 November 2011
...Erin M. Bank; Yosef Gruenbaum In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact...
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Biochem Soc Trans (2009) 37 (3): 569–576.
Published: 20 May 2009
... DSBs normally. Thus NHEJ functions independently of ATM signalling. However, ∼15% of radiation-induced DSBs are repaired with slow kinetics and require ATM and the nuclease Artemis. DSBs persisting in the presence of an ATM inhibitor, ATMi, localize to heterochromatin, suggesting that ATM is required...