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Biochem Soc Trans (2016) 44 (3): 745-752.
Published: 09 June 2016
... cystinuria show endoplasmic reticulum (ER)-retention and a degradation phenotype that correlates with the inability to form heterotetramers despite the presence of disulfide-linked heterodimers [ 42 ]. The heterodimerization of these transporters is strongly linked to their biogenesis. rBAT and b 0,+ AT are...
Biochem Soc Trans (2005) 33 (5): 1003-1007.
Published: 26 October 2005
... recording and nucleotide photolabelling on intact CFTR molecules, we relate opening and closing of the channel gates to ATP-mediated events in the NBDs. In particular, we demonstrate that two CFTR residues, predicted to lie on opposite sides of its anticipated NBD1–NBD2 heterodimer interface, are...