... 2009 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPA receptor) hippocampus leptin N -methyl- D -aspartate receptor (NMDA receptor) synaptic plasticity trafficking Leptin is a 167-amino-acid peptide hormone that is predominantly made by adipose tissue...

...Ann Swijsen; Govert Hoogland; Jean-Michel Rigo Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work...

... -aspartate) receptors] to spatial memory. Studies with GluN2 NMDAR mutants have revealed different contributions from GluN2A- and GluN2B-containing NMDARs to spatial learning. Furthermore, comparison of forebrain- and hippocampus-specific GluN2B-knockout mice has demonstrated that both hippocampal and extra...

... Journal compilation © 2009 Biochemical Society 2009 hippocalcin hippocampus neuronal calcium sensor (NCS) perirhinal cortex synaptic plasticity Calcium-binding proteins are generally divided into two classes, depending on affinity for calcium, binding off-rates and functionality: (i...

... georg001@umn.edu 3 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 brain development fetal iron deficiency hippocampus iron memory References 1 Stoltzfus R.J. Defining iron-deficiency anemia in public health terms: a time for reflection...

... ], we and others have provided convincing experimental evidence that highly mobile soluble oligomers of Aβ rapidly and potently inhibit LTP of synaptic transmission in the hippocampus both in vivo and in vitro [ 3 ]. For example, subnanomolar concentrations of relatively stable, natural, low- n...

... this regulation of neuronal kainate receptor function. 1 email Jack.Mellor@bristol.ac.uk 27 6 2006 © 2006 The Biochemical Society 2006 glutamate receptor hippocampus kainate receptor perirhinal cortex somatosensory cortex synaptic plasticity Studies on the exact...

..., negatively regulates dendritic spine morphogenesis in cultured hippocampal neurons by repressing translation of LIMK1 mRNA. Application of BDNF, which promotes spine morphogenesis, relieves miR-134-mediated repression of LIMK1 translation. brain-derived neurotrophic factor hippocampus long-term...

...-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents...

...R.A. McKinney The vast majority of excitatory connections in the hippocampus are made on dendritic spines. Both dendritic spines and molecules within the membrane are able to move, but the physiological role of these movements is unclear. In the developing brain, spines show highly dynamic...

... Society 2005 age hippocampus inflammation interleukin-10 (IL-10) IL-1β microglial activation It has been established that the role of vitamin D 3 extends beyond its traditional role in bone metabolism [ 32 ] and is capable of modulating immune function by acting on its receptor...

...M.J. Rowan; I. Klyubin; Q. Wang; R. Anwyl AD (Alzheimer's disease) is characterized by a progressive and devastating mental decline that is usually presaged by impairment of a form of memory dependent on medial temporal lobe structures, including the hippocampus. The severity of clinical dementia...

... 5 2001 © 2001 Biochemical Society 2001 hippocampus neurotransmitter transporter protein trafficking synaptic function BIS, bisindolylmaleimide II BDNF, brain-derived neurotrophic factor GABA, γ-aminobutyric acid GAT, GABA transporter HBSS, Hepes-buffered saline solution...