... implicated leptin in the regulation of excitatory synaptic transmission and synaptic plasticity in the hippocampus [ 11 ]. Indeed, obese rodents with mutations in the leptin receptor ( db / db mice and fa / fa rats) exhibit impairments in both hippocampal LTP (long-term potentiation) and LTD (long-term...

...Ann Swijsen; Govert Hoogland; Jean-Michel Rigo Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work...

... -aspartate) receptors] to spatial memory. Studies with GluN2 NMDAR mutants have revealed different contributions from GluN2A- and GluN2B-containing NMDARs to spatial learning. Furthermore, comparison of forebrain- and hippocampus-specific GluN2B-knockout mice has demonstrated that both hippocampal and extra...

... Journal compilation © 2009 Biochemical Society 2009 hippocalcin hippocampus neuronal calcium sensor (NCS) perirhinal cortex synaptic plasticity Myristoylation is a post-translational modification that adds a covalently linked short-chain fatty acid to a glycine residue at position...

... [email protected] 3 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 brain development fetal iron deficiency hippocampus iron memory Iron is a ubiquitous metal that is essential for the function of all mammalian cells and yet also presents...

... and synaptic LTD. Alzheimer's disease amyloid β-peptide (Aβ) glutamatergic transmission hippocampus integrin long-term potentiation (LTP) synaptic memory tumour necrosis factor α (TNFα) In striking contrast, TNFα has a disruptive effect on the induction of LTP in the hippocampus ([ 20 – 22...

... this regulation of neuronal kainate receptor function. 1 email [email protected] 27 6 2006 © 2006 The Biochemical Society 2006 glutamate receptor hippocampus kainate receptor perirhinal cortex somatosensory cortex synaptic plasticity Studies on the exact...

..., negatively regulates dendritic spine morphogenesis in cultured hippocampal neurons by repressing translation of LIMK1 mRNA. Application of BDNF, which promotes spine morphogenesis, relieves miR-134-mediated repression of LIMK1 translation. brain-derived neurotrophic factor hippocampus long-term...

...-hypothalamic brain regions, including hippocampus, brain stem and cerebellum. Moreover, evidence is accumulating that leptin has other neuronal functions that are unrelated to its effects on energy homeostasis. Indeed a role for leptin in neuronal development has been suggested as leptin-deficient rodents...

...R.A. McKinney The vast majority of excitatory connections in the hippocampus are made on dendritic spines. Both dendritic spines and molecules within the membrane are able to move, but the physiological role of these movements is unclear. In the developing brain, spines show highly dynamic...

...M.J. Rowan; I. Klyubin; Q. Wang; R. Anwyl AD (Alzheimer's disease) is characterized by a progressive and devastating mental decline that is usually presaged by impairment of a form of memory dependent on medial temporal lobe structures, including the hippocampus. The severity of clinical dementia...

... ]. On the basis of these findings it might be predicted that the anti-inflammatory effects of vitamin D 3 may extend to the hippocampus and therefore that some of the inflammatory changes induced by age in the hippocampus might be attenuated by treatment of aged rats with vitamin D 3 . To assess this, young...

... 5 2001 © 2001 Biochemical Society 2001 hippocampus neurotransmitter transporter protein trafficking synaptic function BIS, bisindolylmaleimide II BDNF, brain-derived neurotrophic factor GABA, γ-aminobutyric acid GAT, GABA transporter HBSS, Hepes-buffered saline solution...