... information on the residues involved in Pi transport. Using multiple-sequence alignments and homology modelling, the phosphate-binding site residues were shown to be well conserved between all the plant PHT1 proteins, Saccharomyces cerevisiae PHO84 and PiPT. For example, Asp 324 in PiPT is conserved...

... (CC BY) . homology modelling metamorphic proteins protein structure evolution Structural Classification of Proteins (SCOP) Over the past two decades, the Structural Classification of Proteins (SCOP) database has become an essential resource in many areas of protein research [ 1...

... drive the activation of pLGICs, complementing the available experimental data. We have used a series of simulation methods, including homology modelling, ligand–protein docking, density functional theory, molecular dynamics and metadynamics, a powerful scheme for accelerating rare events...

... to the paralogous decahaem cytochrome MtrF, which has been structurally solved through X-ray crystallography. This now allows for homology-based models of MtrC to be generated. The structure of these MtrC homology models contain ten bis-histidine-co-ordinated c -type haems arranged in a staggered cross through...

... activation model β 2 -adrenergic receptor (β 2 -AR) G-protein G-protein-coupled receptor dimerization (GPCR dimerization) homology modelling rotamer toggle switch GPCRs (G-protein-coupled receptors) are dynamic structures, as shown by their ability to dimerize [ 1 ], domain swap [ 2 – 5...

... in both rat brain [ 2 , 6 , 7 ] and human brain [ 8 ]. epilepsy homology modelling mutagenesis racetam binding synaptic vesicle protein 2A (SV2A) © The Authors Journal compilation © 2011 Biochemical Society 2011 LEV levetiracetam MFS major facilitator superfamily rOCT...

... questions of TLR biology further. 1 To whom correspondence should be addressed (email [email protected] ). 16 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ectodomain homology modelling leucine-rich repeat lipopolysaccharide (LPS) Molecular...

... by an inhibition, mutagenesis and homology-modelling approach. Crystal structure and homology modelling indicate that both enzymes possess a narrow constriction that separates an entrance lipophilic channel from the active-site cavity. The role of the constriction as a mobile gate that permits substrate passage...

... ligands. They also lack any apparent enzymic activity. Concurrent with the rapid increase in available genomic sequence data in recent years, it has become apparent that the LTP/LPS-binding proteins are part of a much larger family Key words: BPI, homology modelling, X-ray crystallography. Abbreviations...

... and for modelling structures of other members of the same SFs. 1 To whom correspondence should be addressed (e-mail [email protected] ) 20 2 2001 © 2001 Biochemical Society 2001 alamethicin crystal structure homology modelling membrane sequence database SF, subfamily...