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Keyword: hypoxia
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Articles
Biochem Soc Trans (2018) 46 (3): 599-607.
Published: 20 April 2018
...Andrew J. Murray; Hugh E. Montgomery; Martin Feelisch; Michael P.W. Grocott; Daniel S. Martin Ascent to high altitude is associated with physiological responses that counter the stress of hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation via metabolic...
Articles
Biochem Soc Trans (2016) 44 (4): 1111-1116.
Published: 15 August 2016
... Biochemical Society 2016 cancer metabolism fumarate hydratase hypoxia isocitrate dehydrogenase reactive oxygen species (ROS) succinate dehydrogenase Metabolic reprogramming is now a recognized hallmark of cancer transformation. The first observation of this phenotype was in the early 1920s...
Articles
Biochem Soc Trans (2014) 42 (2): 457-460.
Published: 20 March 2014
...) glycation hypoxia proteostasis unfolded protein response (UPR) Protein homoeostasis, or proteostasis, is conducted through sophisticated networks of mechanisms to maintain the quality of proteins. The quality control of proteins is carefully regulated by the balance of protein synthesis, folding...
Articles
Biochem Soc Trans (2013) 41 (5): 1325-1330.
Published: 23 September 2013
...) mitochondrial complex I hypoxia ischaemia thiol modification thiol nitrosation Production of energy in most aerobic cells is provided by the combined action of the mitochondrial respiratory chain and ATP synthase. Reducing equivalents from pyridine nucleotides (NADH) generated in several catabolic...
Articles
Biochem Soc Trans (2013) 41 (2): 657-663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Biochem Soc Trans (2013) 41 (1): 273-276.
Published: 29 January 2013
...@med.lu.se ). 21 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiogenesis cancer coagulation exosome hypoxia microvesicle The preceding view of intercellular communication in mammalian organisms has been limited to direct cell–cell contact, the...
Articles
Biochem Soc Trans (2011) 39 (6): 1556-1559.
Published: 21 November 2011
... capillarity by more than 50%, (ii) decreases exercise endurance time by approximately 80%, and (iii) abolishes the angiogenic response to exercise training. What causes VEGF to increase with exercise is not clear. Despite regulation by HIF (hypoxia-inducible factor), increased HIF on exercise, and P O 2...
Articles
Biochem Soc Trans (2009) 37 (6): 1221-1227.
Published: 19 November 2009
... compilation © 2009 Biochemical Society 2009 hypoxia ischaemic disease Notch intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) In the Western world, ischaemic disease is highly prevalent and is associated with elevated morbidity and...
Articles
Biochem Soc Trans (2009) 37 (1): 284-288.
Published: 20 January 2009
... should be addressed (email megan.cully@cancer.org.uk ). 23 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 eukaryotic elongation factor 2 kinase (eEF2k) eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) hypoxia mammalian target of rapamycin (mTOR...
Articles
Biochem Soc Trans (2008) 36 (3): 445-448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. 1 To whom correspondence should be addressed (email cormac.taylor...
Articles
Biochem Soc Trans (2007) 35 (5): 905-907.
Published: 25 October 2007
..., University of Leeds, Leeds LS2 9JT, U.K. (email medkep@leeds.ac.uk ). 15 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardiac fibroblast collagen hypoxia invasion matrix metalloproteinase (MMP) myocardial remodelling The adult heart consists of...
Articles
Biochem Soc Trans (2005) 33 (6): 1394-1396.
Published: 26 October 2005
... factors including, particularly oxygen, superoxide, H 2 O 2 , antioxidants, thiols and glycolysis. 1 To whom correspondence should be addressed (email vb207@mole.bio.cam.ac.uk ). 4 7 2005 © 2005 The Biochemical Society 2005 apoptosis hypoxia necrosis nitric oxide (NO...
Articles
Biochem Soc Trans (2005) 33 (5): 1078-1081.
Published: 26 October 2005
... p.trayhurn@liverpool.ac.uk ). 11 7 2005 © 2005 The Biochemical Society 2005 adipokine adipose tissue cytokine hypoxia inflammation metabolic syndrome White adipose tissue (WAT) has become the subject of considerable activity in recent years and is now a ‘hot spot’ in...
Articles
Biochem Soc Trans (2005) 33 (5): 1137-1139.
Published: 26 October 2005
...L. Callinan; T.V. McCarthy; Y. Maulet; J.J. Mackrill One type of cellular response to hypoxia is an increase in cytosolic Ca 2+ . VDCCs (voltage-dependent calcium channels) open upon membrane depolarization allowing inward current of Ca 2+ ions. Two of the so-called L-type VDCC α1 subunits, Ca v...
Articles
Biochem Soc Trans (2004) 32 (6): 1068-1069.
Published: 26 October 2004
... inducible NOS (nitric oxide synthase) highly sensitizes neurons to hypoxia-induced death, probably via the NO–oxygen competition at cytochrome oxidase. Thus the NO from neuronal NOS during excitotoxicity or the NO from inducible NOS during inflammation may sensitize the brain to hypoxic/ischaemic damage...
Articles
Biochem Soc Trans (2004) 32 (6): 943-945.
Published: 26 October 2004
...D.E. Lancaster; M.A. McDonough; C.J. Schofield FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor...
Articles
Biochem Soc Trans (2003) 31 (3): 510-515.
Published: 01 June 2003
...K.S. Hewitson; L.A. McNeill; J.M. Elkins; C.J. Schofield Sensing of ambient dioxygen levels and appropriate feedback mechanisms are essential processes for all multicellular organisms. In animals, moderate hypoxia causes an increase in the transcription levels of specific genes, including those...
Articles
Biochem Soc Trans (2001) 29 (2): 86-90.
Published: 01 May 2001
... fetal growth retardation placenta pre-eclampsia perfusion hypoxia CNS, central nervous system hCG, human chorionic gonadotropin hPL, human placental lactogen IUGR, intra-uterine growth retardation Biochemical Society Transactions (200 I) Volume 29, part 2 Physiological and pathological...
Articles
Biochem Soc Trans (2001) 29 (2): 42-48.
Published: 01 May 2001
...-mail Russ.Anthony@Colostate.edu ) 13 12 2000 © 2001 Biochemical Society 2001 angiogenesis hypoxia intrauterine growth restriction placental lactogen transcription Ang, angiopoietin AP, activator protein bHLH, basis helix-loop-helix CSEn, chorionic somatomammotropin gene...