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Keywords: hypoxia
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Articles
Biochem Soc Trans (2024) 52 (2): 529–538.
Published: 25 March 2024
...Christos Chinopoulos Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD + . This mini-review scrutinizes the persistent...
Articles
Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
...Hannah Bolland; Tiffany S. Ma; Syafiq Ramlee; Kristijan Ramadan; Ester M. Hammond Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O 2 ) cells become up to three times more resistant to radiation. The biological response...
Includes: Supplementary data
Articles
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
... of the role of CHCHD4 and the DRS in physiology and disease, with a specific focus on the emerging importance of CHCHD4 in regulating the cellular response to low oxygen (hypoxia) and metabolism in cancer. Correspondence: Margaret Ashcroft ( m.ashcroft@medschl.cam.ac.uk ) 19 11 2020 19 12...
Articles
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
... of oncometabolites. We also describe emerging evidence that these enzymes are responsive to cellular stresses including hypoxia and DNA damage. Moreover, we examine how dysregulation of 2OG-dependent oxygenases is associated with human disease, and the apparent paradoxical role for some of these enzymes during...
Articles
Biochem Soc Trans (2020) 48 (3): 1121–1128.
Published: 05 May 2020
...Michael Batie; Sonia Rocha Oxygen sensing is an essential feature of metazoan biology and reductions in oxygen availability (hypoxia) have both physiological and pathophysiological implications. Co-ordinated mechanisms have evolved for sensing and responding to hypoxia, which involve diverse...
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Biochem Soc Trans (2014) 42 (2): 457–460.
Published: 20 March 2014
... and UPR (unfolded protein response), which controls the protein homoeostasis state. chronic kidney disease (CKD) endoplasmic reticulum stress (ER stress) glycation hypoxia proteostasis unfolded protein response (UPR) 1 email inagi-npr@umin.ac.jp 6 1 2013 ©...
Articles
Biochem Soc Trans (2013) 41 (5): 1325–1330.
Published: 23 September 2013
... transition) mitochondrial complex I hypoxia ischaemia thiol modification thiol nitrosation Our observations suggest that accumulation of the D-form of the enzyme takes place in highly metabolizing tissues during ischaemia. A/D transition can be considered a natural intrinsic mechanism providing...
Articles
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Biochem Soc Trans (2013) 41 (1): 273–276.
Published: 29 January 2013
... promote tumor progression Cancer Res. 2012 72 4920 4930 15 Brown J.M. Wilson W.R. Exploiting tumour hypoxia in cancer treatment Nat. Rev. 2004 4 437 447 16 Evans S.M. Judy K.D. Dunphy I. Jenkins W.T. Hwang W.T. Nelson P.T. Lustig R.A...
Articles
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... capillarity by more than 50%, (ii) decreases exercise endurance time by approximately 80%, and (iii) abolishes the angiogenic response to exercise training. What causes VEGF to increase with exercise is not clear. Despite regulation by HIF (hypoxia-inducible factor), increased HIF on exercise, and P O 2...
Articles
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis. hypoxia ischaemic disease Notch intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth...
Articles
Biochem Soc Trans (2009) 37 (1): 284–288.
Published: 20 January 2009
... in response to growth factors leads to a disruption of the PRAS40–mTOR interaction and an increase in mTOR kinase activity [ 9 , 10 ]. eukaryotic elongation factor 2 kinase (eEF2k) eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) hypoxia mammalian target of rapamycin (mTOR) stress...
Articles
Biochem Soc Trans (2008) 36 (3): 445–448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. 1 To whom correspondence should be addressed (email cormac.taylor...
Articles
Biochem Soc Trans (2007) 35 (5): 905–907.
Published: 25 October 2007
... healing, leading to the suggestion that this was due to impaired myofibroblast migration to the infarct site [ 2 ]. cardiac fibroblast collagen hypoxia invasion matrix metalloproteinase (MMP) myocardial remodelling The adult heart consists of myocytes, connected and surrounded...
Articles
Biochem Soc Trans (2005) 33 (6): 1394–1396.
Published: 26 October 2005
... 1 To whom correspondence should be addressed (email vb207@mole.bio.cam.ac.uk ). 4 7 2005 © 2005 The Biochemical Society 2005 apoptosis hypoxia necrosis nitric oxide (NO) reactive oxygen species (ROS) superoxide production NO is an important regulator of cell...
Articles
Biochem Soc Trans (2005) 33 (5): 1078–1081.
Published: 26 October 2005
... The Biochemical Society 2005 adipokine adipose tissue cytokine hypoxia inflammation metabolic syndrome White adipose tissue (WAT) has become the subject of considerable activity in recent years and is now a ‘hot spot’ in biomedical research. Much of the basis for this lies in the apparently...
Articles
Biochem Soc Trans (2005) 33 (5): 1137–1139.
Published: 26 October 2005
...L. Callinan; T.V. McCarthy; Y. Maulet; J.J. Mackrill One type of cellular response to hypoxia is an increase in cytosolic Ca 2+ . VDCCs (voltage-dependent calcium channels) open upon membrane depolarization allowing inward current of Ca 2+ ions. Two of the so-called L-type VDCC α1 subunits, Ca v...
Articles
Biochem Soc Trans (2004) 32 (6): 1068–1069.
Published: 26 October 2004
... inducible NOS (nitric oxide synthase) highly sensitizes neurons to hypoxia-induced death, probably via the NO–oxygen competition at cytochrome oxidase. Thus the NO from neuronal NOS during excitotoxicity or the NO from inducible NOS during inflammation may sensitize the brain to hypoxic/ischaemic damage...
Articles
Biochem Soc Trans (2004) 32 (6): 943–945.
Published: 26 October 2004
...D.E. Lancaster; M.A. McDonough; C.J. Schofield FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor...
Articles
Biochem Soc Trans (2003) 31 (3): 510–515.
Published: 01 June 2003
...K.S. Hewitson; L.A. McNeill; J.M. Elkins; C.J. Schofield Sensing of ambient dioxygen levels and appropriate feedback mechanisms are essential processes for all multicellular organisms. In animals, moderate hypoxia causes an increase in the transcription levels of specific genes, including those...
Articles
Biochem Soc Trans (2001) 29 (2): 86–90.
Published: 01 May 2001
... fetal growth retardation placenta pre-eclampsia perfusion hypoxia CNS, central nervous system hCG, human chorionic gonadotropin hPL, human placental lactogen IUGR, intra-uterine growth retardation Biochemical Society Transactions (200 I) Volume 29, part 2 Physiological and pathological...
Articles
Biochem Soc Trans (2001) 29 (2): 42–48.
Published: 01 May 2001
...-mail Russ.Anthony@Colostate.edu ) 13 12 2000 © 2001 Biochemical Society 2001 angiogenesis hypoxia intrauterine growth restriction placental lactogen transcription Ang, angiopoietin AP, activator protein bHLH, basis helix-loop-helix CSEn, chorionic somatomammotropin gene enhancer...