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Keywords: hypoxia
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Articles
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2253–2265.
Published: 25 November 2024
...Tekle Pauzaite; James A. Nathan Hypoxia Inducible transcription Factors (HIFs) are central to the metazoan oxygen-sensing response. Under low oxygen conditions (hypoxia), HIFs are stabilised and govern an adaptive transcriptional programme to cope with prolonged oxygen starvation. However, when...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (2): 529–538.
Published: 25 March 2024
...Christos Chinopoulos Certain cancer cells within solid tumors experience hypoxia, rendering them incapable of oxidative phosphorylation (OXPHOS). Despite this oxygen deficiency, these cells exhibit biochemical pathway activity that relies on NAD + . This mini-review scrutinizes the persistent...
Articles
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1251–1263.
Published: 18 May 2021
...Hannah Bolland; Tiffany S. Ma; Syafiq Ramlee; Kristijan Ramadan; Ester M. Hammond Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O 2 ) cells become up to three times more resistant to radiation. The biological response...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
... of the role of CHCHD4 and the DRS in physiology and disease, with a specific focus on the emerging importance of CHCHD4 in regulating the cellular response to low oxygen (hypoxia) and metabolism in cancer. Studies have shown that dysregulation of the DRS underlies mitochondrial disease [ 23–27 ] and cancer...
Articles
Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
... of oncometabolites. We also describe emerging evidence that these enzymes are responsive to cellular stresses including hypoxia and DNA damage. Moreover, we examine how dysregulation of 2OG-dependent oxygenases is associated with human disease, and the apparent paradoxical role for some of these enzymes during...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1121–1128.
Published: 05 May 2020
...Michael Batie; Sonia Rocha Oxygen sensing is an essential feature of metazoan biology and reductions in oxygen availability (hypoxia) have both physiological and pathophysiological implications. Co-ordinated mechanisms have evolved for sensing and responding to hypoxia, which involve diverse...
Articles
Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 599–607.
Published: 20 April 2018
...Andrew J. Murray; Hugh E. Montgomery; Martin Feelisch; Michael P.W. Grocott; Daniel S. Martin Ascent to high altitude is associated with physiological responses that counter the stress of hypobaric hypoxia by increasing oxygen delivery and by altering tissue oxygen utilisation via metabolic...
Articles
Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1111–1116.
Published: 15 August 2016
... Society 2016 cancer metabolism fumarate hydratase hypoxia isocitrate dehydrogenase reactive oxygen species (ROS) succinate dehydrogenase Dysfunction in IDH, SDH and FH are also involved, directly or indirectly, with the higher levels of ROS often found in cancer cells. Because...
Articles
Glycative stress and glyoxalase in kidney disease and aging
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 457–460.
Published: 20 March 2014
... UPR and regulation of HIF target gene EPO (erythropoietin) expression [ 10 ]. Activated ATF4 by pathogenic UPR state altered the hypoxia-induced EPO production. In particular, hypoxia-induced EPO production was significantly suppressed under ER stress conditions, and it was cancelled by the ER stress...
Articles
Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1325–1330.
Published: 23 September 2013
... complex I in rat heart ( A ) and brain ( B ) tissue after cardiac arrest Percentage of the D-form in samples was determined as described in [ 18 ]. Therefore the A/D transition is a natural adaptive mechanism mediating mitochondrial response to hypoxia. In this section, we discuss several views...
Articles
The impact of hypoxia on cell death pathways
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 657–663.
Published: 21 March 2013
...Colin R. Lenihan; Cormac T. Taylor Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial...
Articles
Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 273–276.
Published: 29 January 2013
... promote tumor progression Cancer Res. 2012 72 4920 4930 15 Brown J.M. Wilson W.R. Exploiting tumour hypoxia in cancer treatment Nat. Rev. 2004 4 437 447 16 Evans S.M. Judy K.D. Dunphy I. Jenkins W.T. Hwang W.T. Nelson P.T. Lustig R.A...
Articles
The critical role of VEGF in skeletal muscle angiogenesis and blood flow
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... capillarity by more than 50%, (ii) decreases exercise endurance time by approximately 80%, and (iii) abolishes the angiogenic response to exercise training. What causes VEGF to increase with exercise is not clear. Despite regulation by HIF (hypoxia-inducible factor), increased HIF on exercise, and P O 2...
Articles
Notch signalling in ischaemia-induced angiogenesis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... (Leeds, U.K.). ADAM a disintegrin and metalloproteinase Dll1 Delta-like 1 Flt4 Fms-like tyrosine kinase 4 HIF-1 hypoxia-inducible factor-1 FIH-1 factor inhibiting HIF-1α Jag1 Jagged-1 kdr kinase insert domain-containing receptor NICD Notch intracellular...
Articles
Translational responses to growth factors and stress
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 284–288.
Published: 20 January 2009
... correspondence should be addressed (email [email protected] ). 23 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 eukaryotic elongation factor 2 kinase (eEF2k) eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) hypoxia mammalian target of rapamycin...
Articles
SUMO, hypoxia and the regulation of metabolism
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 445–448.
Published: 21 May 2008
... deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function. Since its introduction into the earth's atmosphere as a by-product...
Articles
Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 905–907.
Published: 25 October 2007
... variations can strongly influence fibroblast behaviour, which is an important consideration when selecting experimental models for provision of clinically useful information. cardiac fibroblast collagen hypoxia invasion matrix metalloproteinase (MMP) myocardial remodelling The adult heart...
Articles
Signalling role of adipose tissue: adipokines and inflammation in obesity
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1078–1081.
Published: 26 October 2005
... [email protected] ). 11 7 2005 © 2005 The Biochemical Society 2005 adipokine adipose tissue cytokine hypoxia inflammation metabolic syndrome White adipose tissue (WAT) has become the subject of considerable activity in recent years and is now a ‘hot spot...
Articles
Atypical L-type channels are down-regulated in hypoxia
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1137–1139.
Published: 26 October 2005
...L. Callinan; T.V. McCarthy; Y. Maulet; J.J. Mackrill One type of cellular response to hypoxia is an increase in cytosolic Ca 2+ . VDCCs (voltage-dependent calcium channels) open upon membrane depolarization allowing inward current of Ca 2+ ions. Two of the so-called L-type VDCC α1 subunits, Ca v...
Articles
What else has to happen for nitric oxide to induce cell death?
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1394–1396.
Published: 26 October 2005
..., raising the K m of cellular respiration into the physiological range of oxygen concentrations, thus potentially sensitizing cells to hypoxia. Short exposure of the aorta to hypoxia did not cause significant necrosis of the vessel wall in the absence of NO, but caused extensive necrosis in the presence...
Articles
Nitric oxide, hypoxia and brain inflammation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1068–1069.
Published: 26 October 2004
... inducible NOS (nitric oxide synthase) highly sensitizes neurons to hypoxia-induced death, probably via the NO–oxygen competition at cytochrome oxidase. Thus the NO from neuronal NOS during excitotoxicity or the NO from inducible NOS during inflammation may sensitize the brain to hypoxic/ischaemic damage...
Articles
Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 943–945.
Published: 26 October 2004
...D.E. Lancaster; M.A. McDonough; C.J. Schofield FIH (Factor inhibiting hypoxia-inducible factor), an asparaginyl β-hydroxylase belonging to the super-family of 2-oxoglutarate and Fe(II)-dependent dioxygenases, catalyses hydroxylation of Asn-803 of hypoxia-inducible factor, a transcription factor...
Articles
The role of iron and 2-oxoglutarate oxygenases in signalling
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 510–515.
Published: 01 June 2003
...K.S. Hewitson; L.A. McNeill; J.M. Elkins; C.J. Schofield Sensing of ambient dioxygen levels and appropriate feedback mechanisms are essential processes for all multicellular organisms. In animals, moderate hypoxia causes an increase in the transcription levels of specific genes, including those...
Articles
Physiological and pathological regulation of feto/placento/maternal leptin expression
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 86–90.
Published: 01 May 2001
... fetal growth retardation placenta pre-eclampsia perfusion hypoxia CNS, central nervous system hCG, human chorionic gonadotropin hPL, human placental lactogen IUGR, intra-uterine growth retardation Biochemical Society Transactions (200 I) Volume 29, part 2 Physiological and pathological...
Articles
Transcriptional regulation in the placenta during normal and compromised fetal growth
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 42–48.
Published: 01 May 2001
...-mail [email protected] ) 13 12 2000 © 2001 Biochemical Society 2001 angiogenesis hypoxia intrauterine growth restriction placental lactogen transcription Ang, angiopoietin AP, activator protein bHLH, basis helix-loop-helix CSEn, chorionic somatomammotropin gene enhancer...