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Keywords: immune response
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Articles
Biochem Soc Trans (2021) 49 (2): 881–891.
Published: 16 April 2021
..., virulence and immune response mechanisms. Mammalian EVs play an increasingly recognised role to fight infection, yet may also be commandeered to disseminate pathogens and enhance infection. EVs released by bacterial pathogens may deliver toxins to host cells, signalling molecules and new DNA to other...
Articles
Biochem Soc Trans (2018) 46 (5): 1345–1353.
Published: 09 October 2018
... local immune responses by stimulating innate immune cells following exposure to environmental insults, pathogens, or sterile injury. Recent publications have provided new insights into how the range and duration of IL-33 activity is regulated by direct sensing of host-derived and exogenous proteolytic...
Articles
Biochem Soc Trans (2017) 45 (4): 905–911.
Published: 03 July 2017
... 2017 1 6 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 biomarkers cytokines exercise oncology immune response physical training physiology Over the past 25 years, the field of clinical oncology has experienced...
Articles
Biochem Soc Trans (2011) 39 (1): 360–364.
Published: 19 January 2011
...Karin Hoffmann-Sommergruber; Katharina Paschinger; Iain B.H. Wilson Both helminth infections and contact with allergens result in development of a Th2 type of immune response in the affected individual. In this context, the hygiene hypothesis suggests that reduced prevalence of parasitic infections...
Articles
Biochem Soc Trans (2008) 36 (5): 879–884.
Published: 19 September 2008
...-mediated de novo formation of different proteasome compositions as i20S (immunoproteasomes) or m20S (mixed-type proteasomes) essentially supports the rapid adjustment of the mammalian immune system to pathogens. This adjustment is of particular importance for the immune response to rapidly replicating...
Articles
Biochem Soc Trans (2008) 36 (2): 203–211.
Published: 20 March 2008
... that regulate leucocyte trafficking. 1 To whom correspondence should be addressed (email beat.imhof@medecine.unige.ch ). 28 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 adhesion immune response inflammation junctional adhesion molecule (JAM) leucocyte...
Articles
Biochem Soc Trans (2007) 35 (5): 1114–1118.
Published: 25 October 2007
... cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) immune response migration T-cell During an inflammatory response, leucocytes, including primed T-cells, need to cross the endothelial barrier in order to enter non-lymphoid tissue. This process is known as leucocyte extravasation...
Articles
Biochem Soc Trans (2006) 34 (6): 1028–1031.
Published: 25 October 2006
...P.J. Murray IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules required for the full activation of the innate and adaptive immune responses...
Articles
Biochem Soc Trans (2006) 34 (6): 1002–1004.
Published: 25 October 2006
... inflammatory agents are critical for the resolution of immune responses and are well reviewed on pp. 1009–1013 of this issue by Hansell et al. [ 6a ]. There are likely to be a number of mechanisms by which chemokines are regulated in the extracellular space of inflamed tissues, such as tissue-resident...
Articles
Biochem Soc Trans (2006) 34 (6): 1009–1013.
Published: 25 October 2006
... in vivo , as mice lacking D6 show exaggerated cutaneous inflammatory responses and an increased susceptibility to the development of skin cancer. CCX-CKR, on the other hand, is predicted to modulate homoeostatic lymphocyte and dendritic cell trafficking, key migratory events in acquired immune responses...
Articles
Biochem Soc Trans (2003) 31 (3): 637–642.
Published: 01 June 2003
...S. Akira; M. Yamamoto; K. Takeda Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens within the body and the subsequent immune response. Individual TLRs recognize distinct microbial components. The TLRs are a type 1 transmembrane receptor that possess...