... that blocking VEGF-A or CTLA4 alongside PD-L1 is effective in treating advanced HCC. Consequently, some immunotherapies may target and rely on oncofetal cells for clinical responsiveness. This understanding provides exciting opportunities to utilize oncofetal niche characteristics as biomarkers of immunotherapy...

... 2018 16 5 2018 © 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancer glycosyltransferases immunotherapy lectins...

... for preclinical studies and early trials can render the founding concept not always appropriate for proceeding to a larger definitive trial. Here, we summarize the attempts made, to date, to bring MUC1 into the world of cancer immunotherapy and discuss how research findings regarding MUC1 structure and function...

..., or in conjunction with anti-angiogenic therapy or immunotherapy as a promising strategy for the treatment of human cancers. TGF-β signaling is essential to EMT in cancer cells. In squamous cell carcinoma and breast cancer, use of a dominant-negative TβRII abrogated their ability to undergo EMT and migration...

...Lynsey M. Whilding; Sabari Vallath; John Maher Immunotherapy of cancer using chimeric antigen receptor (CAR) T-cells is a rapidly expanding field. CARs are fusion molecules that couple the binding of a tumour-associated cell surface target to the delivery of a tailored T-cell activating signal. Re...

... immunotherapy oncology solid tumours Clinical trials have revealed spectacular efficacy in refractory leukaemia patients using anti-CD19 chimeric antigen receptor (CAR) adoptive T-cell therapy, with a 92% complete remission rate in 39 patients with acute lymphocytic leukaemia (ALL...

... chemotherapy combination therapy immunotherapy photodynamic therapy radiotherapy tyrosine kinase inhibitors The combination of anti-angiogenic and radiotherapy has also been tested in brain tumours. For example, Knisely et al. [ 42 ] combined thalidomide, an inhibitor of bFGF activity, with whole...

... of incontinence and impotence can affect the quality of life of patients. Early intervention with localized immunotherapy represents a potential solution as lymphocyte infiltration does occur in prostate cancer lesions, and immunotherapy with dendritic cell vaccines can significantly increase survival in late...

... 1 To whom correspondence should be addressed (email [email protected] ). 28 3 2005 © 2005 The Biochemical Society 2005 Alzheimer's disease amyloid β protein oligomer glutamatergic transmission hippocampus immunotherapy long-term potentiation Aβ (amyloid β) protein has...

... pharmacokinetic properties to the demands of clinical applications. 1 To whom correspondence should be addressed (e-mail [email protected] ) 11 3 2002 © 2002 Biochemical Society 2002 immunotherapy Fc receptor recombinant ADCC, antibody-dependent cellular...