... and the effects of disease-associated variants remains a vital step in the understanding of neurodegeneration and the development of therapeutics. Disease modelling using patient induced pluripotent stem cells (iPSCs) has enabled the generation of key cell-types associated with disease whilst maintaining...

..., leading to the creation of new models of human illness. These models, derived from induced pluripotent stem cells (iPSCs), facilitate the study of sporadic as well as hereditary diseases and provide a comprehensive understanding of the molecular mechanisms involved with neurodegeneration. Through...

... in authentic, relevant human cells, to discern which of these cellular pathways represent the bona fide function(s) of LRRK2. induced pluripotent stem cells leucine-rich repeat kinase macrophages microglia neuroinflammation Parkinson's disease Parkinson's disease (PD) is a complex...

... genes often result in retinal degeneration. The ability to reprogramme human cells into induced pluripotent stem cells and then differentiate them into a wide range of different cell types has revolutionised our ability to study human disease. To date, however, the challenge of producing fully...

... using well-defined read-outs and potential regenerative approaches. dopaminergic neurons induced pluripotent stem cells Parkin Parkinson's disease PINK1 Parkinson disease (PD) is the second most common neurodegenerative disorder and characterized clinically by the characteristic motor...