... the opposing roles of human E3 ligases as effectors and targets in the evolutionary battle between host and pathogen, specifically in the context of SARS-CoV-2 infection. Through complex effects on transcription, translation, and protein trafficking, human E3 ligases can either attenuate SARS-CoV-2 infection...

...Miquel Àngel Schikora-Tamarit; Toni Gabaldón Fungal pathogens pose an increasingly worrying threat to human health, food security and ecosystem diversity. To tackle fungal infections and improve current diagnostic and therapeutic tools it is necessary to understand virulence and antifungal drug...

.... In this review, we highlight recent advances in defensin research with a particular focus on membrane lipid-targeting in cancer and infection settings. In doing so, we discuss strategies to harness lipid-binding defensins for anticancer and anti-infective therapies. cancer defensin host defence peptide...

... system of the higher vertebrates employs PFPs to kill pathogen-infected cells and transformed cancer cells. The most obvious consequence of membrane pore-formation by the PFPs/PFTs is the killing of the target cells due to the disruption of the permeability barrier function of the plasma membranes. PFPs...

... physiological and pathological situations. Some of these are enlisted below. 16 7 2020 18 9 2020 12 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 infection innate immunity mitochondrial DNA Mitochondria...

...Inge Grondman; Andrei Pirvu; Anca Riza; Mihai Ioana; Mihai G. Netea Sepsis is characterized as a life-threatening organ dysfunction syndrome that is caused by a dysregulated host response to infection. The main etiological causes of sepsis are bacterial, fungal, and viral infections. Last decades...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 antibiotics infection malaria proteoglycan Glycans represent one of the most diverse classes of biological macromolecules. They are a major part of the biomass of every organism...

... by Portland Press Limited 2015 infection inflammation interferons interleukins translation translation initiation Adequate reprogramming of metabolic activities under environmental stress is crucial for cell survival. Regulation at the level of translation provides the necessary plasticity...

... comics, which repairs damaged property arising from conflicts between super heroes and villains. In the context of host microbe interactions, tissue damage control refers to an adaptive response that limits the extent of tissue damage associated with infection. Tissue damage control can limit...

...Jameel M. Inal; Samireh Jorfi Coxsackievirus B1, a member of the Picornaviridae family is a non-enveloped single-stranded RNA virus associated with human diseases including myocarditis and pancreatitis. Infection of the intestinal mucosa, lined by polarized epithelial cells, requires interaction...

...Jameel M. Inal; Ephraim A. Ansa-Addo; Sigrun Lange The release of extracellular vesicles, whether MVs (microvesicles) or exosomes, from host cells or intracellular pathogens is likely to play a significant role in the infection process. Host MVs may fuse with pathogen surfaces to deliver host...

... pathogen clearance. The present review discusses both aspects of NLR activation and will highlight the role of additional inflammasome complexes in sensing infection. 1 email [email protected] 20 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 infection...

... © The Authors Journal compilation © 2007 Biochemical Society 2007 infection innate immunity pattern recognition polymorphism Toll-like receptor Immediate host responses to infectious agents are mediated by pattern-recognition molecules of the innate immune system. Ultimately...

...J.A. Summerfield Mannose-binding lectin (MBL; also known as mannan-binding lectin) is an important component of innate immunity. MBL levels are mainly genetically determined. Low serum MBL levels and their cognate haplotypes have been associated with a wide range of infections. However, most...

... as a mysterious though inevitable natural process. A living organism does not accept decay passively. Virtually all multicellular life forms are capable of resisting infection through the generation of a vigorous immune response. In mammals, the response is so stereotypic that it has come to define sepsis itself...