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Keywords: inhibitors
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Biochem Soc Trans (2020) 48 (3): 933–943.
Published: 26 May 2020
...Glorianne Lazaro; Eleftherios Kostaras; Igor Vivanco Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly...
Biochem Soc Trans (2020) 48 (1): 291–300.
Published: 12 February 2020
...William G. Kerr; Chiara Pedicone; Shawn Dormann; Angela Pacherille; John D. Chisholm Modulating the activity of the Src Homology 2 (SH2) — containing Inositol 5′-Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling...
Biochem Soc Trans (2016) 44 (3): 932–936.
Published: 09 June 2016
...Hershna Patel; Andreas Kukol Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being...
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
... Portland Press Limited 2015 glycolysis inflammation inhibitors isoenzyme macrophage metabolism Macrophages constitute a diverse population of cells that has been clarified in recent years; tissue macrophages have their own self-renewal mechanisms, starting from committed resident cells...
Biochem Soc Trans (2000) 28 (6): 871–872.
Published: 01 December 2000
... inhibitors phospholipase A phospholipase C PLA, phospholipase A Lipids and Signalling: Oxylipins 3 Experimental Etiolated 3-day-old pea seedlings were the object of investigation. Protein kinase activity was rou- tinely assayed at 30 "C by precipitation of szP- labelled phosphorylated protein on...