... complexes. 1 email [email protected] 5 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 elongation factor initiation factor mammalian target of rapamycin (mTOR) mRNA protein kinase protein synthesis Signalling through mTOR (mammalian target...

... of the IFs that act in early steps of initiation. G-protein initiation factor ribosomal subunit joining translation initiation In all domains of life, translation of an mRNA into its encoded protein proceeds through four major steps: initiation, elongation, termination and recycling...

... is necessary for protein synthesis. Phosphorylation of translation initiation factors offers a cost-effective and rapid way to adapt to physiological and environmental changes, and there is increasing evidence that many of these factors are subject to multiple regulatory phosphorylation events. The present...

...R.J. Jackson Of all the steps in mRNA translation, initiation is the one that differs most radically between prokaryotes and eukaryotes. Not only is there no equivalent of the prokaryotic Shine–Dalgarno rRNA–mRNA interaction, but also what requires only three initiation factor proteins (aggregate...

...C. G. Proud; X. Wang; J. V. Patel; L. E. Campbell; M. Kleijn; W. Li; G. J. Browne Protein synthesis in mammalian cells is regulated through alterations in the states of phosphorylation of eukaryotic initiation factors and elongation factors (eIFs and eEFs respectively) and of other regulatory...