...Thomas M. Livermore; Cristina Azevedo; Bernadett Kolozsvari; Miranda S.C. Wilson; Adolfo Saiardi Eukaryotic cells have ubiquitously utilized the myo -inositol backbone to generate a diverse array of signalling molecules. This is achieved by arranging phosphate groups around the six-carbon inositol...

...(1,3,4) P 3 . This article recalls my entanglement with these two inositol phosphates. calcium inositol inositol phosphates inositol trisphosphate This is a personal recollection of events surrounding some scientific discoveries that took place in what were for me two and a half remarkable...

...Michael J. Berridge A wide range of Ca 2+ signalling systems deliver the spatial and temporal Ca 2+ signals necessary to control the specific functions of different cell types. Release of Ca 2+ by Ins P 3 (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems...

... a compelling explanation for many of the known effects of lithium, including effects on early development and insulin signalling/glycogen synthesis. However, lithium also inhibits inositol monophosphatase, several structurally related phosphomonoesterases, phosphoglucomutase and the scaffolding function of β...

... synthase activity and a decrease in the activities of several CDP-diacylglycerol pathway enzymes including the CHO1 -encoded PS (phosphatidylserine) synthase. The reduction in PS synthase in response to zinc depletion is due to a repression mechanism that involves the UAS INO (inositol upstream activating...

...-mediated growth cone collapse. Li + also causes growth cones to spread; however, a similar effect is seen with two other mood stabilizers, valproic acid and carbamazepine, but without changes in microtubules or axon branching. This common effect of mood stabilizers is mediated by changes in inositol...