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Keywords: insulin/IGF-1-like signalling (IIS)
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 721–727.
Published: 20 July 2012
... Alzheimer's disease amyloid insulin/IGF-1-like signalling (IIS) protein misfolding tau AD and all of the age-related neurodegenerative disorders are fundamentally protein-folding disorders. In AD, excessive levels of a peptide, Aβ (amyloid β-peptide), and a protein, the MAPT (microtubule...
