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Keyword: insulin secretion
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Articles
Biochem Soc Trans (2019) BST20190513.
Published: 07 November 2019
...Mauricio Di Fulvio; Lydia Aguilar-Bryan It is accepted that insulin-secreting β-cells release insulin in response to glucose even in the absence of functional ATP-sensitive K + (K ATP )-channels, which play a central role in a ‘consensus model’ of secretion broadly accepted and widely reproduced in...
Articles
Biochem Soc Trans (2019) 47 (2): 571-590.
Published: 01 April 2019
... pivotal part of this regulation as they are primarily responsible for controlling cellular and circulating amino acid concentrations. The availability of amino acids regulated by transporters can amplify insulin secretion and modulate insulin signalling in various tissues. In addition, insulin itself can...
Articles
Biochem Soc Trans (2018) 46 (3): 555-564.
Published: 17 April 2018
...Charles Affourtit; Ben Alberts; Jonathan Barlow; Jane E. Carré; Anthony G. Wynne The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual as it...
Articles
Biochem Soc Trans (2012) 40 (4): 800-803.
Published: 20 July 2012
...Jonathan M. Locke; Lorna W. Harries Recent studies in mouse, involving the β-cell-specific deletion of Dicer1, have highlighted the crucial role of miRNAs (microRNAs) in regulating insulin secretion and consequently Type 2 diabetes. Identifying the individual miRNAs involved in human islet...
Articles
Biochem Soc Trans (2010) 38 (1): 205-208.
Published: 19 January 2010
...Angela McDonald; Sarah Fogarty; Isabelle Leclerc; Elaine V. Hill; D. Grahame Hardie; Guy A. Rutter Glucose-stimulated insulin secretion from pancreatic β-cells requires the kinesin-1/Kif5B-mediated transport of insulin granules along microtubules. 5′-AMPK (5′-AMP-activated protein kinase) is a...
Articles
Biochem Soc Trans (2008) 36 (5): 916-919.
Published: 19 September 2008
... (email t.biden@garvan.org.au ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 glucose-stimulated insulin secretion insulin secretion lipotoxicity pancreatic β-cell protein kinase C (PKC) Type 2 diabetes The PKC (protein kinase C) family of...
Articles
Biochem Soc Trans (2008) 36 (5): 955-958.
Published: 19 September 2008
... present review, we focus on exogenous and endogenous effects of NEFAs, including the polyunsaturated fatty acid, arachidonic acid (or its metabolites generated from cyclo-oxygenase activity), on β-cell metabolism, and have explored the outcomes with respect to β-cell insulin secretion. 1 To whom...
Articles
Biochem Soc Trans (2008) 36 (5): 891-900.
Published: 19 September 2008
...Mary C. Sugden; Mark J. Holness In healthy individuals, a hyperbolic relationship exists between whole-body insulin-sensitivity and insulin secretion. Thus, for any difference in insulin-sensitivity, a reciprocal proportionate change occurs in insulin secretion. Such a feedback loop is evident in...
Articles
Biochem Soc Trans (2008) 36 (3): 357-359.
Published: 21 May 2008
...). The risk alleles have been associated with reduced glucose and GLP-1 (glucagon-like peptide 1)-stimulated insulin secretion. Recent evidence has suggested that inheritance of the at-risk T allele at SNP rs7903146 may increase the expression of TCF7L2 in adult human islets. However, the cellular...
Articles
Biochem Soc Trans (2007) 35 (5): 1180-1186.
Published: 25 October 2007
...P. Newsholme; K. Bender; A. Kiely; L. Brennan In addition to the primary stimulus of glucose, specific amino acids may acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Mitochondrial metabolism is crucial for the coupling of glucose, alanine...
Articles
Biochem Soc Trans (2006) 34 (5): 802-805.
Published: 25 October 2006
...C.B. Chan; N. Kashemsant UCPs (uncoupling proteins) can regulate cellular ATP production by uncoupling oxidative phosphorylation. UCP2 is expressed in islet β-cells and its induction reduces glucose-stimulated insulin secretion. Under physiological conditions, superoxide, formed as a by-product of...
Articles
Biochem Soc Trans (2006) 34 (5): 824-827.
Published: 25 October 2006
... this signal transduction mechanism, mitochondria integrate and generate metabolic signals, thereby coupling glucose recognition with insulin secretion. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic Ca 2+ , in the...
Articles
Biochem Soc Trans (2006) 34 (5): 675-678.
Published: 25 October 2006
... (email g.a.rutter@bris.ac.uk or g.rutter@imperial.ac.uk ). 31 7 2006 © 2006 The Biochemical Society 2006 β-cell confocal microscopy dynamin-1 exocytosis insulin secretion three-dimensional imaging Defective insulin secretion underlies the pathology of both Type 1...
Articles
Biochem Soc Trans (2006) 34 (2): 243-246.
Published: 20 March 2006
... frances.ashcroft@physiol.ox.ac.uk 2 12 2005 © 2006 The Biochemical Society 2006 ATP-sensitive potassium channel (K ATP channel) diabetes insulin secretion Kir6.2 nicotinamide nucleotide transhydrogenase (Nnt) sulphonylurea K ATP channels (ATP-sensitive K channels) play a key role...
Articles
Biochem Soc Trans (2006) 34 (2): 247-250.
Published: 20 March 2006
...G.A. Rutter; A. Varadi; T. Tsuboi; L. Parton; M. Ravier Defective insulin secretion from pancreatic islet β-cells is a sine qua non of Type II (non-insulin-dependent) diabetes. Digital imaging analysis of the nanomechanics of individual exocytotic events, achieved using total internal reflection...
Articles
Biochem Soc Trans (2003) 31 (6): 1115-1119.
Published: 01 December 2003
... glucose and fatty acids interact. These include stimulation of hepatic glucose output by fatty acids, potentiation of glucose-stimulated insulin secretion by fatty acids, and the cellular mechanism whereby high glucose and insulin concentrations inhibit fatty acid oxidation via malonyl-CoA regulation of...
Articles
Biochem Soc Trans (2002) 30 (2): 323-327.
Published: 01 April 2002
...M. V. Mikhailov; E. A. Mikhailova; S. J. H. Ashcroft The ATP-sensitive potassium (K ATP ) channel plays a key role in controlling β-cell membrane potential and insulin secretion. The channels are composed of two subunits, Kir6.2, which forms the channel pore, and SUR1, which contains binding sites...