... on behalf of the Biochemical Society 2023 elongation control integrated stress response ribosomes stress response translation ubiquitin Eukaryotic cells are constantly exposed to a range of challenging conditions, such as starvation or heat, osmotic, oxidative, UV radiation...

... is inhibited, such as during the integrated stress response (ISR), and may facilitate cellular adaptation to stress. The ribosome-associated quality control (RQC) pathway is a critical translation monitoring system that recognizes aberrant mRNAs encoding potentially toxic nascent peptides to target them...

..., a pharmacological compound known as ISRIB (integrated stress response inhibitor) has been identified that is able to inhibit the inhibition of eIF2B by phosphorylated eIF2, without dissociating the subunits from the complex [ 27 , 28 ]. As noted above, incomplete eIF2B complexes display reduced GEF activity...

... (eIF2α) integrated stress response palmitate palmitoleate pancreatic β-cell The rising tide of obesity within the developed world constitutes one of the primary risk factors for Type 2 diabetes among these populations and is usually associated with hyperlipidaemia. This leads to alterations...