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Keyword: integrin
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Articles
Biochem Soc Trans (2018) 46 (3): 649-658.
Published: 09 May 2018
... interactions as well as neutrophil recruitment to sites of inflammation. Here, we summarise key processes that are dependent upon small GTPases in leukocytes during these early inflammatory events. We place a particular focus on the regulation of integrin-dependent events and their control by Rho and Rap...
Articles
Biochem Soc Trans (2015) 43 (1): 122-128.
Published: 26 January 2015
... matrixes are subject to dynamic cell-mediated structural and chemical modification. In this article, we discuss how localized application of mechanical force, heterodimer-specific integrin engagement and matrix proteolysis regulate fibronectin assembly and turnover. We also speculate that recently...
Articles
Biochem Soc Trans (2014) 42 (6): 1643-1646.
Published: 17 November 2014
... cell heparan sulfate integrin syndecan Syndecans are type I transmembrane glycoproteins that belong to the heparan sulfate proteoglycan (HSPG) superfamily. Four members have been characterized in vertebrates with different functions and expression profiles. Most cell types, with the...
Articles
Biochem Soc Trans (2014) 42 (6): 1623-1628.
Published: 17 November 2014
... Biochemical Society 2014 angiogenesis endothelial cell integrin neuropilin semaphorin vascular endothelial growth factor vascular permeability The cardiovascular system is the first organ system to develop during embryogenesis in vertebrates. Vasculogenesis enables the creation of new...
Articles
Biochem Soc Trans (2012) 40 (6): 1404-1408.
Published: 21 November 2012
... cells by regulating integrin trafficking. Recently, our laboratory uncovered a critical role for Rab25 in cellular energetics. Assimilating all of the existing evidence, in the present review, we give an updated overview of the complex and often context-dependent role of Rab25 in cancer. 1 To whom...
Articles
Biochem Soc Trans (2011) 39 (2): 563-567.
Published: 22 March 2011
...Dale Powner; Petra M. Kopp; Susan J. Monkley; David R. Critchley; Fedor Berditchevski Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to...
Articles
Biochem Soc Trans (2011) 39 (2): 568-573.
Published: 22 March 2011
...Xanthippi Alexi; Fedor Berditchevski; Elena Odintsova Integrins and growth factor receptors of the ErbB family are involved in the regulation of cellular interactions with the extracellular microenvironment. Cross-talk between these two groups of transmembrane receptors is essential for cellular...
Articles
Biochem Soc Trans (2011) 39 (1): 374-377.
Published: 19 January 2011
... understanding the biology of the disease. The multistage nature of melanoma development, which is accompanied by changes in the expression of adhesion receptors from the integrin family, provides a chance for searching for neoglycoforms of proteins that can be considered as future sensitive melanoma biomarkers...
Articles
Biochem Soc Trans (2009) 37 (4): 849-854.
Published: 22 July 2009
... normal lung, TGFβ is maintained in an inactive state that is tightly regulated temporally and spatially. One of the major TGFβ-activation pathways involves integrins, and the role of the αvβ6 integrin has been particularly well described in the pathogenesis of IPF. Owing to the pleiotropic nature of TGFβ...
Articles
Biochem Soc Trans (2008) 36 (2): 229-234.
Published: 20 March 2008
...Asoka Banno; Mark H. Ginsberg Agonist stimulation of integrin receptors, composed of transmembrane α and β subunits, leads cells to regulate integrin affinity (‘activation’), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation...
Articles
Biochem Soc Trans (2008) 36 (2): 257-262.
Published: 20 March 2008
...) domains and TB (transforming growth factor β-binding protein-like) domains. TB4 contains an RGD (Arg-Gly-Asp) integrin-binding motif. The atomic structure of this region has been solved by X-ray crystallography and shows the TB4 and flanking cbEGF domains to be arranged as a tetragonal pyramid with N- and...
Articles
Biochem Soc Trans (2008) 36 (2): 263-266.
Published: 20 March 2008
...Iain D. Campbell Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and...
Articles
Biochem Soc Trans (2008) 36 (2): 235-239.
Published: 20 March 2008
...Wolfgang H. Ziegler; Alex R. Gingras; David R. Critchley; Jonas Emsley Integrins are αβ heterodimeric receptors that mediate attachment of cells to the extracellular matrix and therefore play important roles in cell adhesion, migration, proliferation and survival. Among the cytoskeletal proteins...
Articles
Biochem Soc Trans (2008) 36 (2): 241-250.
Published: 20 March 2008
... by nine amino acids, we have mapped the binding of receptors and other proteins on to collagens II or III. Integrin α2β1 binds to several GXX′GER motifs within the collagens, the affinities of which differ sufficiently to control cell adhesion and migration independently of the cellular regulation of...
Articles
Biochem Soc Trans (2007) 35 (5): 1306-1309.
Published: 25 October 2007
... RNA modulation and Affymetrix expression profiles. 1 To whom correspondence should be addressed (email j.timmons@hw.ac.uk ). 20 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Affymetrix endurance exercise integrin microRNA non-coding RNA...
Articles
Biochem Soc Trans (2007) 35 (5): 1219-1223.
Published: 25 October 2007
... neurodegeneration occurs. Soluble Aβ oligomers can rapidly disrupt synaptic memory mechanisms at extremely low concentrations via stress-activated kinases and oxidative/nitrosative stress mediators. Here, we summarize experiments that investigated whether certain putative receptors for Aβ, the αv integrin...
Articles
Biochem Soc Trans (2007) 35 (4): 647-651.
Published: 20 July 2007
.... 1 To whom correspondence should be addressed (email gjloffice@ucl.ac.uk ). 26 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cytokine fibroblast fibrosis integrin lung matrix turnover Chronic disorders of the joints and internal organs are...
Articles
Biochem Soc Trans (2006) 34 (6): 1261-1266.
Published: 25 October 2006
... receptors are expressed in the microvasculature and by neurons and their supporting glial cells. Cells within cerebral microvessels express both the integrin and dystroglycan families of matrix adhesion receptors. However, the functional significance of these receptors is only now being explored...
Articles
Biochem Soc Trans (2005) 33 (6): 1308-1312.
Published: 26 October 2005
...D.R. Critchley The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. In this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches to...
Articles
Biochem Soc Trans (2005) 33 (4): 609-613.
Published: 01 August 2005
...A. Grande-García; A. Echarri; M.A. Del Pozo Integrins are crucial regulators of essential cellular processes such as gene expression, cell proliferation and migration. Alteration of these processes is central to tumourigenesis. Integrin signals mediate anchorage dependence of cell growth, while...
Articles
Biochem Soc Trans (2004) 32 (5): 831-836.
Published: 26 October 2004
...D.R. Critchley The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such...
Articles
Biochem Soc Trans (2004) 32 (5): 822-825.
Published: 26 October 2004
... contractile cytoskeleton to the plasma membrane, but there is also evidence that integrin receptors modulate signalling events that are essential for cellular differentiation. A major challenge is now to integrate work at the atomic, molecular and cellular levels, and obtain holistic insights into the...
Articles
Biochem Soc Trans (2004) 32 (5): 826-827.
Published: 26 October 2004
...A. Arcangeli; A. Becchetti; A. Cherubini; O. Crociani; P. Defilippi; L. Guasti; G. Hofmann; S. Pillozzi; M. Olivotto; E. Wanke Integrins are adhesion receptors capable of transmitting intracellular signals that regulate many different cellular functions. Among integrin-mediated signals, the...
Articles
Biochem Soc Trans (2004) 32 (3): 438-442.
Published: 01 June 2004
...S. Cabodi; L. Moro; E. Bergatto; E. Boeri Erba; P. Di Stefano; E. Turco; G. Tarone; P. Defilippi Integrin signalling co-ordinates with signalling originating from growth factor receptors in the co-operative control of cell proliferation, survival and migration. Increasing evidence suggests that...
Articles
Biochem Soc Trans (2004) 32 (3): 403-406.
Published: 01 June 2004
...J. Takagi Since the discovery of the RGD sequence motif as the essential cell attachment site in Fn (fibronectin), RGD-dependent ligand recognition by integrins has been the major focus of many integrin researches. Although many integrins recognize RGD-containing ligands, it is believed that...
Articles
Biochem Soc Trans (2004) 32 (3): 443-446.
Published: 01 June 2004
...R.L. Juliano; P. Reddig; S. Alahari; M. Edin; A. Howe; A. Aplin Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase...
Articles
Biochem Soc Trans (2004) 32 (3): 407-411.
Published: 01 June 2004
...M.J. Humphries Integrins are a family of heterodimeric, transmembrane receptors that mediate a range of cell–cell and cell–extracellular matrix interactions in an array of physiological and pathophysiological situations. Integrin-mediated cell adhesion is dynamically regulated in vivo to facilitate...
Articles
Biochem Soc Trans (2004) 32 (3): 434-437.
Published: 01 June 2004
...D.A. Calderwood Tight, dynamic control of the affinity of integrin adhesion receptors for their extracellular ligands (integrin activation) is essential for the development and functioning of multicellular organisms. Integrin activation is controlled by intracellular signals that, through their...
Articles
Biochem Soc Trans (2004) 32 (3): 397-402.
Published: 01 June 2004
... vessels. The changes that characterize tumour blood vessels include selective expression of certain integrins. Peptides isolated by in vivo phage display for homing to tumours have been shown to be useful in directing therapeutic agents to experimental tumours. The targeting can enhance the efficacy of...
Articles
Biochem Soc Trans (2003) 31 (1): 83-86.
Published: 01 February 2003
... have been reported, we were unable to find functional evidence for an interaction of endogenous Rap1 signalling with the Raf/extracellular-signal-regulated kinase (ERK) pathway. Instead we observe a clear connection of Rap1 with inside-out signalling to integrins. Indeed, introduction of a...
Articles
Biochem Soc Trans (2002) 30 (2): 173-177.
Published: 01 April 2002
... attachment of these cells to basement membrane components, with a concomitant increase in matrix metallo-proteinase 2 activation, (ii) Thrombin upregulates the expression of integrin α v β 3 , the marker of the angiogenic phenotype of endothelial cells. (iii) Thrombin has chemotactic and aptotactic effects...
Articles
Biochem Soc Trans (2001) 29 (2): 171-176.
Published: 01 May 2001
... myofilament assembly in body-wall muscle during embryonic development. 1 To whom correspondence should be addressed (e-mail moerman@zoology.ubc.ca ) 6 11 2000 © 2001 Biochemical Society 2001 adhesion complex alternative splicing integrin proteoglycan LDL, low-density...