...Simran Chhabra; Manjula Kalia Guanylate-binding proteins (GBPs) are immune GTPases that are induced in response to interferon stimulation/pathogen infection. These proteins arose early in evolution and have multiple physiological roles ranging from tumor suppression to anti-microbial functions...

...Huy-Dung Hoang; Parisa Naeli; Tommy Alain; Seyed Mehdi Jafarnejad Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN...

...Nicolas C. Hoch The COVID-19 pandemic has prompted intense research efforts into elucidating mechanisms of coronavirus pathogenesis and to propose antiviral interventions. The interferon (IFN) response is the main antiviral component of human innate immunity and is actively suppressed by several...

...Heike L. Rafeld; Waldemar Kolanus; Ian R. van Driel; Elizabeth L. Hartland Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. Upon IFN stimulation, these GTPases are highly expressed in various...

... by Portland Press Limited 2015 infection inflammation interferons interleukins translation translation initiation Adequate reprogramming of metabolic activities under environmental stress is crucial for cell survival. Regulation at the level of translation provides the necessary plasticity...