...Ian C. Scott; D. Gareth Rees; E. Suzanne Cohen Interleukin (IL)-1 family cytokines are important initiators of innate immunity and host defence; however, their uncontrolled activities can cause tissue-damaging inflammation. Consequently, IL-1 family cytokines have sophisticated regulatory...

... [ 6 ], suggesting at least an association of neutrophilic inflammation with progressive fibrosis in the lung. Finally, the predominant inflammatory cell in ARDS (acute respiratory distress syndrome) is the neutrophil, with levels of the neutrophil chemoattractant IL (interleukin) -8 related...

... muscles express several cytokines, which belong to distinct cytokine classes. IL-6 (interleukin-6) is a pleiotropic cytokine produced by virtually all multinucleated cells including skeletal myocytes where it is produced in response to contraction. IL-6 is subsequently released into the circulation, where...

... 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis chemokine interleukin neutrophil stroke systemic inflammation Most stroke patients present with co-morbidities, such as atherosclerosis, hypertension, diabetes or infection, all...

... Focused Meeting held at New Edinburgh Royal Infirmary, Little France, Nr. Edinburgh, 19–20 November 2003 25 November 2003 © 2004 Biochemical Society 2004 apoptosis Bcl-2 interleukin Mcl-1 neutrophil Abbreviations used: Bcl-2, B-cell lymphocytic-leukaemia proto-oncogene...

... an extracellular leucine-rich repeat domain and cytoplasmic domain homologous with that of the interleukin 1 receptor (IL-1R) family. Upon stimulation, TLR recruits the IL-1R-associated kinase (IRAK) via the adapter MyD88, ultimately leading to the activation of nuclear factor-κB. Cytokine production in response...

... RNA-dependent protein kinase)-independent, but TIRAP (Toll/interleukin-1 receptor domain-containing adapter protein)/Mal (MyD88-adapter-like)-dependent. In the present paper, we outline the recent controversy over the role of TIRAP/Mal in TLR2 and TLR4 signalling in the context of the current...