... is a current research aim. To achieve this, a more complete understanding of the release mechanisms, expression of receptors, transporters, and the secretion pattern of the different EEC types is needed. Using the vascularly perfused intestinal model, it is possible to obtain a detailed knowledge...

...Reegan J. Willms; Edan Foley The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized intestinal epithelial cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier...

... -type homeobox 2). In normal development, this is expressed in the future intestine, but not the future foregut. Mouse knockout studies have shown that it is needed for intestinal development, and that its loss from adult intestine can lead to squamous transformations. It is also expressed in Barrett's...

.... These include induction of antimicrobial peptides, proliferation and wound healing in the intestine. The pathogenesis of IBD, ulcerative colitis and Crohn's disease may be due to increased TLR or decreased TLR signalling respectively. Finally, we discuss the possible role of TLR signalling in colitis-associated...

... genes in the tissue of choice and at a given time [Maddison and Clarke (2005) J. Pathol. 205 , 181–193; Shaw and Clarke (2007) DNA Repair 6, 1403–1412; Marsh and Clarke (2007) Expert Rev. Anticancer Ther. 7 , 519–531]. We have used these approaches to study tumorigenesis in the murine intestine. Loss...

... or tumour growth. Since the intestine has the highest metabolic activity of all the internal organs, a tumour will initially compete with the gut for nutrients and energy-providing molecules. The polyamines represent a class of molecules where the demand in the body increases during tumour growth. A tumour...

.... No significant differences were observed in PPAR mRNA levels in the intestine, where CD36 does not impact on FA uptake. The data suggest that CD36 and the PPARs are components of the FA-sensing machinery to respond to changes in FA flux in a tissue-specific manner. 1 To whom correspondence should...

...J. Dyer; K.S.H. Salmon; L. Zibrik; S.P. Shirazi-Beechey The composition of the intestinal luminal content varies considerably with diet. It is important therefore that the intestinal epithelium senses and responds to these significant changes and regulates its functions accordingly. Although...

...M.A. Cuff; S.P. Shirazi-Beechey Butyrate is a naturally occurring monocarboxylate, produced in the lumen of the colon by microbial fermentation of complex carbohydrates that escape digestion in the small intestine. It serves as the principal metabolic fuel for colonic epithelial cells, and exerts...

... to variations in glucose concentration has increased recently. The epithelial cells lining the intestinal tract are exposed, from the luminal domain, to an environment with continuous and massive fluctuations in the levels of dietary monosaccharides. Enterocytes therefore have to sense and respond...

... To whom correspondence should be addressed (e-mail [email protected] ) 10 4 2002 © 2002 Biochemical Society 2002 duodenal cytochrome b intestine neutrophil Dcytb, duodenal cytochrome b DCT, divalent-cation transporter Biometals 2002: Third International...

...G.J. Anderson; D. M. Frazer; S.J. Wilkins; E. M. Becker; K. N. Millard; T. L. Murphy; A. T. McKie; C. D. Vulpe Hepcidin is an anti-microbial peptide predicted to be involved in the regulation of intestinal iron absorption. We have examined the relationship between the expression of hepcidin...