... 5 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 amyotrophic lateral sclerosis biomolecular condensates intrinsically disordered proteins Matrin-3 neurodegeneration RNA-binding proteins Matrin-3 (MATR3...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 adenosine triphosphate conformational changes intrinsically disordered proteins neurotrophic factors small endogenous ligand weak interactions Neurotrophins (NTs) constitute a family of secreted...

...Shanlong Li; Yumeng Zhang; Jianhan Chen Intrinsically disordered proteins (IDPs) are one of the major drivers behind the formation and characteristics of biomolecular condensates. Due to their inherent flexibility, the backbones of IDPs are significantly exposed, rendering them highly influential...

.... Correspondence: Sylvie Ricard-Blum ( [email protected] ) 19 2 2023 3 6 2023 7 6 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 co-receptors interaction networks intrinsically disordered proteins proteoglycan...

...(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription...

... mass spectrometry intrinsically disordered proteins PI4K protein–protein interactions A significant proportion of the human proteome is composed of regions that display a high degree of conformational flexibility and lack characterizable secondary structure. This includes proteins...

... with p-sites in disordered regions. The latter makes these amino acid sequences crossroads for signaling and motif strength between kinases, pSer/pThr-binding proteins and phosphatases. 14-3-3 proteins intrinsically disordered proteins protein phosphatases protein-serine-threonine kinases...

...Nike Heinß; Mikhail Sushkin; Miao Yu; Edward A. Lemke Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups...

... to fuzzy logic, disordered and ordered binding modes co-exist, and their gradual shift drives the system towards the amyloid state. context-dependence fuzzy complexes fuzzy logic intrinsically disordered proteins protein–protein interactions Traditionally, we consider a statement either...

... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. intracellular signaling intrinsically disordered proteins membrane dynamics The discovery and characterization of intrinsically disordered proteins...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 CRIB effectors intrinsically disordered proteins protein conformation small G-proteins The field of small G-protein biology, as much as any other, has been dominated and beautifully informed...

[email protected] ) 13 9 2017 10 12 2017 8 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes protein–protein interaction quality control...

... compounds that target intrinsically disordered proteins (IDPs) such as Myc directly is a daunting challenge due to the absence of stable and well-defined pockets that could be probed with small molecules [ 5 , 6 ]. Because of these difficulties, many attempts have been made to inhibit Myc indirectly...

... BY) . alternative splicing biological networks gene expression and regulation intrinsically disordered proteins protein turnover RNA localization Understanding how proteins, which are polymers of amino acids, carry out different functions in a cell has been a problem of considerable interest...

...Mi-Kyung Yoon; Diana M. Mitrea; Li Ou; Richard W. Kriwacki Today, it is widely accepted that proteins that lack highly defined globular three-dimensional structures, termed IDPs (intrinsically disordered proteins), play key roles in myriad biological processes. Our understanding of how intrinsic...