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Keywords: intron
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Articles
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
.... The advance of high-throughput sequencing enabled rapid progress in mapping the functional elements in our genome. In the present article, I discuss how intronic mutations acting at Alu elements enable formation of new exons. I review the mutations that cause disease when promoting a major increase...
Articles
Biochem Soc Trans (2013) 41 (4): 1017–1022.
Published: 18 July 2013
... in size (~55-fold). Almost all of this expansion is a direct result of an increase in the size of the introns. The coding region of CASK orthologues, and hence the protein, exhibit a high degree of evolutionary conservation. Within the protein, domain arrangement is completely conserved and substitution...
Articles
Biochem Soc Trans (2008) 36 (3): 514–516.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 exon–exon junction complex (EJC) intron nonsense-mediated mRNA decay (NMD) nuclear translation splicing translation NMD has been studied in several organisms and it appears to be an active process requiring specific trans...
Articles
Biochem Soc Trans (2004) 32 (6): 928–931.
Published: 26 October 2004
...I.A. Turner; C.M. Norman; M.J. Churcher; A.J. Newman Most protein-coding genes in eukaryotes are interrupted by non-coding intervening sequences (introns), which must be precisely removed from primary gene transcripts (pre-mRNAs) before translation of the message into protein. Intron removal by pre...