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Keywords: intron
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
.... The advance of high-throughput sequencing enabled rapid progress in mapping the functional elements in our genome. In the present article, I discuss how intronic mutations acting at Alu elements enable formation of new exons. I review the mutations that cause disease when promoting a major increase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (4): 1017–1022.
Published: 18 July 2013
... in size (~55-fold). Almost all of this expansion is a direct result of an increase in the size of the introns. The coding region of CASK orthologues, and hence the protein, exhibit a high degree of evolutionary conservation. Within the protein, domain arrangement is completely conserved and substitution...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 514–516.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 exon–exon junction complex (EJC) intron nonsense-mediated mRNA decay (NMD) nuclear translation splicing translation NMD has been studied in several organisms and it appears to be an active process requiring specific trans...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 928–931.
Published: 26 October 2004
...I.A. Turner; C.M. Norman; M.J. Churcher; A.J. Newman Most protein-coding genes in eukaryotes are interrupted by non-coding intervening sequences (introns), which must be precisely removed from primary gene transcripts (pre-mRNAs) before translation of the message into protein. Intron removal by pre...