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1-23 of 23
Keywords: ion channel
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Articles
What voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 827–839.
Published: 13 April 2023
...Yasushi Okamura; Daisuke Yoshioka Many membrane proteins including ion channels and ion transporters are regulated by membrane phospholipids such as phosphoinositides in cell membranes and organelles. Voltage-sensing phosphatase, VSP, is a voltage-sensitive phosphoinositide phosphatase which...
Articles
The structural basis of cystic fibrosis
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... transmembrane conductance regulator ion channel protein structure transmembrane proteins NMR was also employed to study the interactions of the third soluble ‘domain’ in CFTR, the 200 residue-long Regulatory-region or R-region [ 18 , 20 ]. These interactions were studied with several potential...
Articles
The varied functions of aluminium-activated malate transporters–much more than aluminium resistance
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (3): 856–862.
Published: 09 June 2016
...Antony J. Palmer; Alison Baker; Stephen P. Muench The ALMT (aluminium-activated malate transporter) family comprises a functionally diverse but structurally similar group of ion channels. They are found ubiquitously in plant species, expressed throughout different tissues, and located in either...
Articles
Functions of inorganic polyphosphates in eukaryotic cells: a coat of many colours
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 98–102.
Published: 23 January 2014
.... They have been described in various tissues and subcellular localizations [ 5 , 6 ]. DAPI staining inorganic polyphosphate ion channel metabolism sol–gel transition transcription regulation In higher eukaryotes, polyP has been implicated in many vital aspects of cellular physiology...
Articles
Pathways of colicin import: utilization of BtuB, OmpF porin and the TolC drug-export protein
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1463–1468.
Published: 21 November 2012
... is deleted. 1 To whom correspondence should be addressed (email [email protected] ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin drug export ion channel outer membrane protein receptor An understanding of the molecular mechanism of colicin import would...
Articles
Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... consists of thinner sections of the cortical ER enriched in STIM1 and devoid of chaperones that appear to be specialized ER compartments dedicated to Ca 2+ signalling. calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM...
Articles
Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1347–1354.
Published: 19 November 2009
... regions of the GluN2D subunit. Our results show that the identity of the GluN2 LBD not only controls glutamate potency, but also influences the potency of the NMDAR co-agonist glycine, whereas the single-channel conductance and the duration of single activations of ion channels can be predicted...
Articles
When pain after surgery doesn't go away…
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 318–322.
Published: 20 January 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 ion channel neural blockade neuroplasticity noradrenaline pain surgery In 1999, Macrae and Davies [ 1 ] proposed a working definition for CPSP (chronic post-surgical pain) based on four criteria, namely: (i) pain developed...
Articles
Chromatin switching and transcriptional regulation in disease
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
... to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis...
Articles
P2X 7 receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... and the current understanding of the signalling pathways from receptor to RONS generators. 1 To whom correspondence should be addressed (email [email protected] ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ATP ion channel NADPH oxidase P2X 7...
Articles
Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... chromatography tandem MS MDCK cell Madin–Darby canine kidney cell SILAC stable isotope labelling with amino acids in cell culture References 1 Walaas S.I. Greengard P. Pharmacol. Rev. 1991 43 299 349 2 Hille B. Ion Channels of Excitable Membranes 2001...
Articles
The role of abnormal trafficking of KCNE1 in long QT syndrome 5
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
... fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the α- and β-subunits, KCNQ1 and KCNE1 respectively, of the K + channel pore I Ks are the commonest cause of LQTS and account for LQTS types 1 and 5 respectively (LQT1 and LQT5). Recently...
Articles
Ion channels in epilepsy
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation...
Articles
The function of the NADPH oxidase of phagocytes, and its relationship to other NOXs
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
... be addressed (email [email protected] ). 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chronic granulomatous disease (CGD) ion channel NADPH oxidase neutrophil oxidase phagocyte reactive oxygen species Phagocytosis by neutrophils is accompanied...
Articles
Do polymorphisms in the human 5-HT 3 genes contribute to pathological phenotypes?
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 872–876.
Published: 25 October 2006
...K. Krzywkowski 5-HT 3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT 3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT 3 receptors are known...
Articles
Novel structural determinants of single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 882–886.
Published: 25 October 2006
...J.A. Peters; J.E. Carland; M.A. Cooper; M.R. Livesey; T.Z. Deeb; T.G. Hales; J.J. Lambert Nicotinic ACh (acetylcholine) and 5-HT 3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate...
Articles
Physical and functional interaction between integrins and hERG potassium channels
Available to PurchaseA. Arcangeli, A. Becchetti, A. Cherubini, O. Crociani, P. Defilippi, L. Guasti, G. Hofmann, S. Pillozzi, M. Olivotto, E. Wanke
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 826–827.
Published: 26 October 2004
..., the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG ( h uman e ther-a-go-go- r elated g ene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining...
Articles
Ca2+-induced Ca2+ release in cardiac and smooth muscle cells
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (5): 943–946.
Published: 01 October 2003
... Focused Meeting held at University of Liverpool, 1–2 May 2003 1 May 2003 © 2003 Biochemical Society 2003 Ca 2+ channel Ca 2+ spark Fura-2 ion channel ryanodine receptor sarcoplasmic reticulum Abbreviations used: [Ca 2+ ] i , intracellular calcium concentration; STOC...
Articles
Assembly of N-methyl-d-aspartate (NMDA) receptors
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 865–868.
Published: 01 August 2003
...R.A.J. McIlhinney; E. Philipps; B. Le Bourdelles; S. Grimwood; K. Wafford; S. Sandhu; P. Whiting The N -methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different...
Articles
Setting the screen: balancing quality with quantity
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 785.
Published: 01 August 2002
...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail [email protected] ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...
Articles
A flexible technology platform to explore valuable drug targets
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 786–788.
Published: 01 August 2002
... there has been a revolution in plate formats from 96, 384, 1536 to 3456 and beyond. Organon has Key words: high-throughput screening, ion channel, nuclear receptor. Abbreviations used: FRET, fluorescence resonance energy trans- fer; VIPR. voltage/ion probe reader; HTS, high-throughput screening. E...
Articles
Structural model of a voltage-gated potassium channel based on spectroscopic data
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 589–593.
Published: 01 August 2001
... interact with membranes and thereby attain their folded structure. An approach that we have been exploring involves dissecting voltage-gated ion channels into simple peptide domains for the purpose of determining their structure in different media using physical techniques. We have synthesized peptides...
Articles
Cyclic-nucleotide- and Ca 2+ /calmodulin-regulated channels in plants: targets for manipulating heavy-metal tolerance, and possible physiological roles
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (4): 471–475.
Published: 01 August 2000
... the involvement of NtCBP4 in heavy-metal tolerance and to elucidate its physiological role. 1 To whom correspondence should be addressed at the University of Leeds (e-mail [email protected] ) 23 2 2000 © 2000 Biochemical Society 2000 ion channel Pb toxicity signal transduction...