...Yasushi Okamura; Daisuke Yoshioka Many membrane proteins including ion channels and ion transporters are regulated by membrane phospholipids such as phosphoinositides in cell membranes and organelles. Voltage-sensing phosphatase, VSP, is a voltage-sensitive phosphoinositide phosphatase which...

... transmembrane conductance regulator ion channel protein structure transmembrane proteins NMR was also employed to study the interactions of the third soluble ‘domain’ in CFTR, the 200 residue-long Regulatory-region or R-region [ 18 , 20 ]. These interactions were studied with several potential...

...Antony J. Palmer; Alison Baker; Stephen P. Muench The ALMT (aluminium-activated malate transporter) family comprises a functionally diverse but structurally similar group of ion channels. They are found ubiquitously in plant species, expressed throughout different tissues, and located in either...

.... They have been described in various tissues and subcellular localizations [ 5 , 6 ]. DAPI staining inorganic polyphosphate ion channel metabolism sol–gel transition transcription regulation In higher eukaryotes, polyP has been implicated in many vital aspects of cellular physiology...

... is deleted. 1 To whom correspondence should be addressed (email [email protected] ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin drug export ion channel outer membrane protein receptor An understanding of the molecular mechanism of colicin import would...

... consists of thinner sections of the cortical ER enriched in STIM1 and devoid of chaperones that appear to be specialized ER compartments dedicated to Ca 2+ signalling. calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM...

... regions of the GluN2D subunit. Our results show that the identity of the GluN2 LBD not only controls glutamate potency, but also influences the potency of the NMDAR co-agonist glycine, whereas the single-channel conductance and the duration of single activations of ion channels can be predicted...

... The Authors Journal compilation © 2009 Biochemical Society 2009 ion channel neural blockade neuroplasticity noradrenaline pain surgery In 1999, Macrae and Davies [ 1 ] proposed a working definition for CPSP (chronic post-surgical pain) based on four criteria, namely: (i) pain developed...

... to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis...

... and the current understanding of the signalling pathways from receptor to RONS generators. 1 To whom correspondence should be addressed (email [email protected] ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ATP ion channel NADPH oxidase P2X 7...

... chromatography tandem MS MDCK cell Madin–Darby canine kidney cell SILAC stable isotope labelling with amino acids in cell culture References 1 Walaas S.I. Greengard P. Pharmacol. Rev. 1991 43 299 349 2 Hille B. Ion Channels of Excitable Membranes 2001...

... fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the α- and β-subunits, KCNQ1 and KCNE1 respectively, of the K + channel pore I Ks are the commonest cause of LQTS and account for LQTS types 1 and 5 respectively (LQT1 and LQT5). Recently...

...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation...

... be addressed (email [email protected] ). 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chronic granulomatous disease (CGD) ion channel NADPH oxidase neutrophil oxidase phagocyte reactive oxygen species Phagocytosis by neutrophils is accompanied...

...K. Krzywkowski 5-HT 3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT 3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT 3 receptors are known...

...J.A. Peters; J.E. Carland; M.A. Cooper; M.R. Livesey; T.Z. Deeb; T.G. Hales; J.J. Lambert Nicotinic ACh (acetylcholine) and 5-HT 3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate...

..., the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG ( h uman e ther-a-go-go- r elated g ene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining...

... Focused Meeting held at University of Liverpool, 1–2 May 2003 1 May 2003 © 2003 Biochemical Society 2003 Ca 2+ channel Ca 2+ spark Fura-2 ion channel ryanodine receptor sarcoplasmic reticulum Abbreviations used: [Ca 2+ ] i , intracellular calcium concentration; STOC...

...R.A.J. McIlhinney; E. Philipps; B. Le Bourdelles; S. Grimwood; K. Wafford; S. Sandhu; P. Whiting The N -methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different...

...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail [email protected] ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...

... there has been a revolution in plate formats from 96, 384, 1536 to 3456 and beyond. Organon has Key words: high-throughput screening, ion channel, nuclear receptor. Abbreviations used: FRET, fluorescence resonance energy trans- fer; VIPR. voltage/ion probe reader; HTS, high-throughput screening. E...

... interact with membranes and thereby attain their folded structure. An approach that we have been exploring involves dissecting voltage-gated ion channels into simple peptide domains for the purpose of determining their structure in different media using physical techniques. We have synthesized peptides...

... the involvement of NtCBP4 in heavy-metal tolerance and to elucidate its physiological role. 1 To whom correspondence should be addressed at the University of Leeds (e-mail [email protected] ) 23 2 2000 © 2000 Biochemical Society 2000 ion channel Pb toxicity signal transduction...