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Keywords: ion channel
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Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... transmembrane conductance regulator ion channel protein structure transmembrane proteins CFTR is a member of the ATP-binding cassette (ABC) family of proteins [ 1 – 3 ]. As such, CFTR has the standard four-domain structure consisting of two transmembrane domains and two soluble nucleotide-binding...
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Biochem Soc Trans (2016) 44 (3): 856–862.
Published: 09 June 2016
...Antony J. Palmer; Alison Baker; Stephen P. Muench The ALMT (aluminium-activated malate transporter) family comprises a functionally diverse but structurally similar group of ion channels. They are found ubiquitously in plant species, expressed throughout different tissues, and located in either...
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Biochem Soc Trans (2014) 42 (1): 98–102.
Published: 23 January 2014
... polyphosphate ion channel metabolism sol–gel transition transcription regulation PolyP (inorganic polyphosphate) is a linear polymer of orthophosphate residues linked by phosphoanhydride bonds as in ATP ( Figure 1 ). PolyP structure is flexible with no inherent tertiary structure. This polymer...
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Biochem Soc Trans (2012) 40 (6): 1463–1468.
Published: 21 November 2012
... or a different Omp receptor. (iv) On the basis of a limited number of examples, an extended (≥100 Å; 1 Å=0.1 nm) coiled-coil R-domain, found for example in the structures of nuclease colicins E2 [ 12 ] and E3 [ 13 , 14 ] or the ion channel-forming colicin Ia [ 15 ], is associated with utilization of two...
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Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... compilation © 2012 Biochemical Society 2012 calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM) References 1 Putney J.W. Jr A model for receptor-regulated calcium entry Cell Calcium 1986 7 1 12...
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Biochem Soc Trans (2009) 37 (6): 1347–1354.
Published: 19 November 2009
... regions of the GluN2D subunit. Our results show that the identity of the GluN2 LBD not only controls glutamate potency, but also influences the potency of the NMDAR co-agonist glycine, whereas the single-channel conductance and the duration of single activations of ion channels can be predicted...
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Biochem Soc Trans (2009) 37 (1): 318–322.
Published: 20 January 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 ion channel neural blockade neuroplasticity noradrenaline pain surgery Currently, treatment of CPSP is determined by the nature of the presenting symptoms and signs. A presentation of neuropathic pain is generally limited...
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Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
... to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis...
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Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... signalling molecule that is implicated in numerous cellular processes from synaptic transmission to inflammation [ 1 ]. Extracellular ATP activates a class of cell-surface nucleotide receptors termed P2 receptors that are further categorized into P2Y (G-protein-linked) and P2X (ligand-gated ion channels...
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Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... as the major substrate for phosphorylation. Ion Channels: A Focus Topic at Life Sciences 2007, held at SECC Glasgow, U.K., 9–12 July 2007. Edited by D. Fedida (British Columbia, Canada), A. Lee (Southampton, U.K.) and F. Michelangeli (Birmingham, U.K.). The Kv2.1 cytoplasmic N- and C-termini...
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Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
... fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the α- and β-subunits, KCNQ1 and KCNE1 respectively, of the K + channel pore I Ks are the commonest cause of LQTS and account for LQTS types 1 and 5 respectively (LQT1 and LQT5). Recently...
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Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
... be addressed (email [email protected] ). 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chronic granulomatous disease (CGD) ion channel NADPH oxidase neutrophil oxidase phagocyte reactive oxygen species Phagocytosis by neutrophils is accompanied...
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Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation...
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Biochem Soc Trans (2006) 34 (5): 882–886.
Published: 25 October 2006
...J.A. Peters; J.E. Carland; M.A. Cooper; M.R. Livesey; T.Z. Deeb; T.G. Hales; J.J. Lambert Nicotinic ACh (acetylcholine) and 5-HT 3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate...
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Biochem Soc Trans (2006) 34 (5): 872–876.
Published: 25 October 2006
...K. Krzywkowski 5-HT 3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT 3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT 3 receptors are known...
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Biochem Soc Trans (2004) 32 (5): 826–827.
Published: 26 October 2004
..., the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG ( h uman e ther-a-go-go- r elated g ene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining...
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Biochem Soc Trans (2003) 31 (5): 943–946.
Published: 01 October 2003
... Focused Meeting held at University of Liverpool, 1–2 May 2003 1 May 2003 © 2003 Biochemical Society 2003 Ca 2+ channel Ca 2+ spark Fura-2 ion channel ryanodine receptor sarcoplasmic reticulum Abbreviations used: [Ca 2+ ] i , intracellular calcium concentration; STOC...
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Biochem Soc Trans (2003) 31 (4): 865–868.
Published: 01 August 2003
...R.A.J. McIlhinney; E. Philipps; B. Le Bourdelles; S. Grimwood; K. Wafford; S. Sandhu; P. Whiting The N -methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different...
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Biochem Soc Trans (2002) 30 (4): 785.
Published: 01 August 2002
...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail [email protected] ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...
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Biochem Soc Trans (2002) 30 (4): 786–788.
Published: 01 August 2002
... high-throughput screening ion channel nuclear receptor FRET, fluorescence resonance energy transfer VIPR, voltage/ion probe reader HTS, high-throughput screening Biochemical Society Transactions (2002) Volume 30, part 4 A flexible technology platform to explore valuable drug targets J. H...
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Biochem Soc Trans (2001) 29 (4): 589–593.
Published: 01 August 2001
... interact with membranes and thereby attain their folded structure. An approach that we have been exploring involves dissecting voltage-gated ion channels into simple peptide domains for the purpose of determining their structure in different media using physical techniques. We have synthesized peptides...
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