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Keyword: ion channel
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Articles
Biochem Soc Trans (2018) 46 (5): 1093–1098.
Published: 28 August 2018
... transmembrane conductance regulator ion channel protein structure transmembrane proteins CFTR is a member of the ATP-binding cassette (ABC) family of proteins [ 1 – 3 ]. As such, CFTR has the standard four-domain structure consisting of two transmembrane domains and two soluble nucleotide-binding...
Articles
Biochem Soc Trans (2016) 44 (3): 856–862.
Published: 09 June 2016
...Antony J. Palmer; Alison Baker; Stephen P. Muench The ALMT (aluminium-activated malate transporter) family comprises a functionally diverse but structurally similar group of ion channels. They are found ubiquitously in plant species, expressed throughout different tissues, and located in either the...
Articles
Biochem Soc Trans (2014) 42 (1): 98–102.
Published: 23 January 2014
... polyphosphate ion channel metabolism sol–gel transition transcription regulation PolyP (inorganic polyphosphate) is a linear polymer of orthophosphate residues linked by phosphoanhydride bonds as in ATP ( Figure 1 ). PolyP structure is flexible with no inherent tertiary structure. This polymer is...
Articles
Biochem Soc Trans (2012) 40 (6): 1463–1468.
Published: 21 November 2012
... deleted. 1 To whom correspondence should be addressed (email waclab@purdue.edu ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin drug export ion channel outer membrane protein receptor An understanding of the molecular mechanism of colicin import would...
Articles
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
... compilation © 2012 Biochemical Society 2012 calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM) Cytosolic Ca 2+ elevations control a large array of cellular functions, notably the contraction of cardiac and...
Articles
Biochem Soc Trans (2009) 37 (6): 1347–1354.
Published: 19 November 2009
... regions of the GluN2D subunit. Our results show that the identity of the GluN2 LBD not only controls glutamate potency, but also influences the potency of the NMDAR co-agonist glycine, whereas the single-channel conductance and the duration of single activations of ion channels can be predicted by the...
Articles
Biochem Soc Trans (2009) 37 (1): 318–322.
Published: 20 January 2009
... Authors Journal compilation © 2009 Biochemical Society 2009 ion channel neural blockade neuroplasticity noradrenaline pain surgery In 1999, Macrae and Davies [ 1 ] proposed a working definition for CPSP (chronic post-surgical pain) based on four criteria, namely: (i) pain developed...
Articles
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
... to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis...
Articles
Biochem Soc Trans (2007) 35 (5): 1168–1170.
Published: 25 October 2007
... and the current understanding of the signalling pathways from receptor to RONS generators. 1 To whom correspondence should be addressed (email a.mackenzie@bath.ac.uk ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ATP ion channel NADPH oxidase...
Articles
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... correspondence should be addressed (email jtrimmer@ucdavis.edu ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcineurin electrical signalling ion channel mass spectrometry neuron protein kinase Protein phosphorylation constitutes one of the major...
Articles
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
... fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the α- and β-subunits, KCNQ1 and KCNE1 respectively, of the K + channel pore I Ks are the commonest cause of LQTS and account for LQTS types 1 and 5 respectively (LQT1 and LQT5). Recently...
Articles
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation to...
Articles
Biochem Soc Trans (2007) 35 (5): 1100–1103.
Published: 25 October 2007
... correspondence should be addressed (email t.segal@ucl.ac.uk ). 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chronic granulomatous disease (CGD) ion channel NADPH oxidase neutrophil oxidase phagocyte reactive oxygen species Phagocytosis by...
Articles
Biochem Soc Trans (2006) 34 (5): 872–876.
Published: 25 October 2006
...K. Krzywkowski 5-HT 3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT 3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT 3 receptors are known...
Articles
Biochem Soc Trans (2006) 34 (5): 882–886.
Published: 25 October 2006
...J.A. Peters; J.E. Carland; M.A. Cooper; M.R. Livesey; T.Z. Deeb; T.G. Hales; J.J. Lambert Nicotinic ACh (acetylcholine) and 5-HT 3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate...
Articles
Biochem Soc Trans (2004) 32 (5): 826–827.
Published: 26 October 2004
... activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG ( h uman e ther-a-go-go- r elated g ene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining...
Articles
Biochem Soc Trans (2003) 31 (5): 943–946.
Published: 01 October 2003
... Focused Meeting held at University of Liverpool, 1–2 May 2003 1 May 2003 © 2003 Biochemical Society 2003 Ca 2+ channel Ca 2+ spark Fura-2 ion channel ryanodine receptor sarcoplasmic reticulum Abbreviations used: [Ca 2+ ] i , intracellular calcium concentration; STOC...
Articles
Biochem Soc Trans (2003) 31 (4): 865–868.
Published: 01 August 2003
...R.A.J. McIlhinney; E. Philipps; B. Le Bourdelles; S. Grimwood; K. Wafford; S. Sandhu; P. Whiting The N -methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different...
Articles
Biochem Soc Trans (2002) 30 (4): 785.
Published: 01 August 2002
...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail a.clark@organon.co.uk ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...
Articles
Biochem Soc Trans (2002) 30 (4): 786–788.
Published: 01 August 2002
... high-throughput screening ion channel nuclear receptor FRET, fluorescence resonance energy transfer VIPR, voltage/ion probe reader HTS, high-throughput screening Biochemical Society Transactions (2002) Volume 30, part 4 A flexible technology platform to explore valuable drug targets J. H...
Articles
Biochem Soc Trans (2001) 29 (4): 589–593.
Published: 01 August 2001
... interact with membranes and thereby attain their folded structure. An approach that we have been exploring involves dissecting voltage-gated ion channels into simple peptide domains for the purpose of determining their structure in different media using physical techniques. We have synthesized peptides...
Articles
Biochem Soc Trans (2000) 28 (4): 471–475.
Published: 01 August 2000
... the involvement of NtCBP4 in heavy-metal tolerance and to elucidate its physiological role. 1 To whom correspondence should be addressed at the University of Leeds (e-mail h.fromm@leeds.ac.uk ) 23 2 2000 © 2000 Biochemical Society 2000 ion channel Pb toxicity signal...