...Eleonora Centonze; Stephan Kellenberger Voltage-clamp fluorometry (VCF) has revolutionized the study of ion channels by combining electrophysiology with fluorescence spectroscopy. VCF allows ion channel researchers to link dynamic structural changes, measured in real time, to function. Acid-sensing...

..., polyP, and polyhydroxybutyrate (PHB); (2) modulation of the channel activity of PHBlated protein channels; and (3) direct effects of polyP on the function of the voltage-gated ion channels in the process that do not involve PHB. © 2024 The Author(s). Published by Portland Press Limited on behalf...

...Delfine Cheng; Junfan Wang; Mingxi Yao; Charles D Cox Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory...

...Shreyas Bhat; Rikard Blunck Ion channels undergo major conformational changes that lead to channel opening and ion conductance. Deciphering these structure-function relationships is paramount to understanding channel physiology and pathophysiology. Cryo-electron microscopy, crystallography...

... vasoconstriction and vascular remodelling. Ion channels are key determinants of vascular smooth muscle tone and homeostasis, and four PAH channelopathies ( KCNK3 , ABCC8 , KCNA5 , TRPC6 ) have been identified so far. However, the contribution of ion channels in other forms of PAH, which account for the majority...

...Vassiliy N. Bavro; Sayan Gupta; Corie Ralston Membrane proteins, such as receptors, transporters and ion channels, control the vast majority of cellular signalling and metabolite exchange processes and thus are becoming key pharmacological targets. Obtaining structural information by usage...