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Keywords: isoleucyl-tRNA synthetase
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1109–1120.
Published: 17 June 2024
... of methicillin-resistant Staphylococcus aureus strains. Mupirocin inhibits protein synthesis by blocking the active site of isoleucyl-tRNA synthetase (IleRS), which prevents the enzyme from binding isoleucine and ATP for Ile-tRNA Ile synthesis. Two types of IleRS are found in bacteria — while IleRS1...
