... trafficking and receptor tyrosine kinase (RTK) degradation [ 6 ]. In addition to highlighting findings on these major fields of USP8 research, we will discuss additional functions of USP8 that have emerged in recent years. Cushings disease DUBs isopeptidase ubiquitin proteasome system UBPy USP8...

..., Progenra has developed a novel assay to measure the proteolytic cleavage of Ub (ubiquitin) or UBL (Ub-like protein) conjugates such as SUMO (small Ub-related modifier), NEDD8 (neural-precursor-cell-expressed, developmentally down-regulated 8) or ISG15 (interferon-stimulated gene 15) by isopeptidases...