...Akanksha Baharani; Brett Trost; Anthony Kusalik; Scott Napper There is increasing appreciation among researchers and clinicians of the value of investigating biology and pathobiology at the level of cellular kinase (kinome) activity. Kinome analysis provides valuable opportunity to gain insights...

... nevertheless have yielded only limited success with many different malignancies due to the inability of single agents to sustain a durable clinical response. Cancer cell kinomes are highly resilient and able to bypass targeted kinase inhibition, leading to tumour resistance. A novel platform has been developed...

... 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 kinome protein scaffold pseudoenzyme pseudokinase thermal shift assay Protein kinase complements, or ‘kinomes’, are found within, and regulate cell biology across, all annotated phyla, including archaea...